EFFECT OF FEEDING MILK REPLACER ON GROWTH PERFORMANCE OF YAK CALVES

ABSTRACT An investigation was carried out on 18 numbers of new bor

Impact of Dapagliflozin Adjunctive Therapy on Progression of Chronic Kidney Disease in Patients with Type 2 Diabetes and CKD Stage 2–5: A systematic review and meta-analysis

This meta-analysis was conducted by searching PubMed, Scopus, Cochrane, Ovid till November 2022 for randomized controlled trials (RCTs) that utilized dapagliflozin 10 mg as adjunctive therapy in patients with T2DM and CKD stage 2-5 and reported its renal efficacy in terms of mean change in estimated glomerular filtration rate (eGFR) and urinary albumin creatinine ratio (UACR) from baseline. From 1682 identified records, nine studies representing 13,057 patients were selected for this study. Pooled estimate of five studies showed that dapagliflozin did not affect eGFR but caused significantly less chronic eGFR decline than placebo in two studies [Mean difference (MD) +2.74 (95% CI: 1.55, 3.92; p < 0.00001)]. Pooled estimate of four studies showed that dapagliflozin significantly reduced UACR[-23.99 % MD (95% CI - 34.82, -13.15, p-value < 0.0001; = 0%)]. This confirms that long-term dapagliflozin use significantly attenuates eGFR decline and reduces albuminuria in T2DM and CKD stages 2-5 patients. Keywords: Chronic kidney disease, Dapagliflozin, Estimated GFR, eGFR, SGLT2 inhibitors, Type 2 diabetes mellitus, Urine albumin to creatinine ratio, UACR

Spatio-temporal analysis of decadal-scale patterns in barrier island response to storms: Perdido Key, NW Florida

The ability to accurately quantify shoreline variability is essential in order to establish aggressive mitigation strategies, based on recent global climate change projections. This investigation employed a suite of coastal data (topographic maps, aerial photography, satellite imagery and lidar) to establish decadal trends of shoreline movement along Perdido Key, a sandy barrier island off Florida’s northwest coast. The technique used to detect morphologic change with time was a recently developed tool, Analyzing Moving Boundaries Using R. This innovative methodology improves our understanding of the evolution of coastal systems by modeling shoreline variance using a method that is sensitive to shoreline shape. Results show that the barrier shoreline is a highly dynamic feature with distinct zones of erosion and accretion that are pervasive over time. In general, the island is displaying a mechanism of rotational instability with the eastern half retreating, and the western portion advancing. The inflection point, around which this rotational shifting is taking place, lies at the center of a Pleistocene headland located along the island’s midpoint. The results of this study suggest that coastal evolution along the island may be meta-stable, with trends in shoreline variance corresponding mainly to discrete storm events in time