Filtering of the signal of sediment export from a glacier by Its proglacial forefield

This is the final version. Available from Wiley via the DOI in this record. Data Availability Statement: The data used in this study (i.e., water discharge, suspended sediment load and bedload records for 2020 and 2021) are archivied in Zenodo. These are available in (Mancini et al., 2023; Müller & Miesen, 2022).Alpine glaciers are rapidly retreating due to global warming and this has been associated with enhanced supply of subglacially derived sediment to downstream environments. We present the first high frequency quantitative record on how the signal of sediment exported from an Alpine glacier is filtered by its proglacial forefield. The data, covering two climatically distinct glacier melt seasons, show that the signal of subglacial bedload export is strongly filtered over short distances, unlike suspended load whose signal is less impacted. The reason is related to the interplay of short particle advection lengths with strong morphodynamic forcing. The subglacial sediment export signal is thus rapidly replaced by one combining (a) the local forcing by stream hydraulics and (b) the reworking of the proglacial braid plain itself. These findings have implications for estimating subglacial erosion rates, natural hazard mitigation, sediment management for hydropower plants and ecological succession related to rapid glacier retreat.Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschun

The effect of source credibility on the evaluation of statements in a spiritual and scientific context: a registered report study

Action Contro

Recognising the agency of people with dementia.

People with dementia have been assumed to possess weak or even no agency, so this paper provides a novel contribution to academic debate by examining their actual potential for agency. The author draws on findings from a qualitative study of everyday decision-making by people with dementia that aimed to identify the role of social factors (such as gender) in influencing their involvement in decisions. Whilst decision-making constitutes a form of deliberative agency, the research also identified when agency was alternatively habituated, embodied or emotional. The Economic and Social Research Council-funded research was undertaken in the North of England. Existing theoretical perspectives on agency are critiqued, particularly in relation to rationality, language and individualised agency. The study highlighted that people with dementia who lack deliberative capacity can nonetheless demonstrate creative capacity for agency. A more expansive concept of agency is needed in social science theory that is informed by the experiences of cognitively disabled people

Determinants of impact : towards a better understanding of encounters with the arts

The article argues that current methods for assessing the impact of the arts are largely based on a fragmented and incomplete understanding of the cognitive, psychological and socio-cultural dynamics that govern the aesthetic experience. It postulates that a better grasp of the interaction between the individual and the work of art is the necessary foundation for a genuine understanding of how the arts can affect people. Through a critique of philosophical and empirical attempts to capture the main features of the aesthetic encounter, the article draws attention to the gaps in our current understanding of the responses to art. It proposes a classification and exploration of the factors—social, cultural and psychological—that contribute to shaping the aesthetic experience, thus determining the possibility of impact. The ‘determinants of impact’ identified are distinguished into three groups: those that are inherent to the individual who interacts with the artwork; those that are inherent to the artwork; and ‘environmental factors’, which are extrinsic to both the individual and the artwork. The article concludes that any meaningful attempt to assess the impact of the arts would need to take these ‘determinants of impact’ into account, in order to capture the multidimensional and subjective nature of the aesthetic experience

Dementia: beyond disorders of mood

This editorial will present the growing argument in the research literature that mood disorders, as defined by psychiatric diagnostic criteria, do not well serve individuals with dementia. This is important because anxiety and depression are our most used and most influential ways of understanding a highly prevalent and personally important experience in dementia: emotion. As such, there is a need to review how the disorders are currently conceptualised since they may have limited applicability for individuals with dementia, and consider what alternatives there might be. Agitation is offered as a lesson in how imprecise descriptions of behaviour can exclude the internal world of people with dementia. In our research to explore how the emotional experiences of individuals with dementia are understood, we consider what might lie beyond disorders of mood

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human induced pluripotent stem cell-derived kidney organoids with SARS-CoV-2. Single cell RNA-sequencing indicated injury and dedifferentiation of infected cells with activation of pro-fibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in Long-COVID

Regulation of microRNA biogenesis and turnover by animals and their viruses

Item does not contain fulltextMicroRNAs (miRNAs) are a ubiquitous component of gene regulatory networks that modulate the precise amounts of proteins expressed in a cell. Despite their small size, miRNA genes contain various recognition elements that enable specificity in when, where and to what extent they are expressed. The importance of precise control of miRNA expression is underscored by functional studies in model organisms and by the association between miRNA mis-expression and disease. In the last decade, identification of the pathways by which miRNAs are produced, matured and turned-over has revealed many aspects of their biogenesis that are subject to regulation. Studies in viral systems have revealed a range of mechanisms by which viruses target these pathways through viral proteins or non-coding RNAs in order to regulate cellular gene expression. In parallel, a field of study has evolved around the activation and suppression of antiviral RNA interference (RNAi) by viruses. Virus encoded suppressors of RNAi can impact miRNA biogenesis in cases where miRNA and small interfering RNA pathways converge. Here we review the literature on the mechanisms by which miRNA biogenesis and turnover are regulated in animals and the diverse strategies that viruses use to subvert or inhibit these processes

Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis

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