2,496 research outputs found

    The transient response of global-mean precipitation to increasing carbon dioxide levels

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    The transient response of global-mean precipitation to an increase in atmospheric carbon dioxide levels of 1% yr(-1) is investigated in 13 fully coupled atmosphere-ocean general circulation models (AOGCMs) and compared to a period of stabilization. During the period of stabilization, when carbon dioxide levels are held constant at twice their unperturbed level and the climate left to warm, precipitation increases at a rate of similar to 2.4% per unit of global-mean surface-air-temperature change in the AOGCMs. However, when carbon dioxide levels are increasing, precipitation increases at a smaller rate of similar to 1.5% per unit of global-mean surface-air-temperature change. This difference can be understood by decomposing the precipitation response into an increase from the response to the global surface-temperature increase (and the climate feedbacks it induces), and a fast atmospheric response to the carbon dioxide radiative forcing that acts to decrease precipitation. According to the multi-model mean, stabilizing atmospheric levels of carbon dioxide would lead to a greater rate of precipitation change per unit of global surface-temperature change

    The Virtues of M\u27Naghten

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    Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast

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    Genetic instability is a hallmark of aneuploidy in budding and fission yeast. All aneuploid yeast strains analyzed to date harbor elevated levels of Rad52-GFP foci, a sign of DNA damage. Here we investigate how continuously elevated levels of DNA damage affect aneuploid cells. We show that Rad52-GFP foci form during S phase, consistent with the observation that DNA replication initiation and elongation are impaired in some aneuploid yeast strains. We furthermore find that although DNA damage is low in aneuploid cells, it nevertheless has dramatic consequences. Many aneuploid yeast strains adapt to DNA damage and undergo mitosis despite the presence of unrepaired DNA leading to cell death. Wild-type cells exposed to low levels of DNA damage exhibit a similar phenotype, indicating that adaptation to low levels of unrepaired DNA is a general property of the cell's response to DNA damage. Our results indicate that by causing low levels of DNA damage, whole-chromosome aneuploidies lead to DNA breaks that persist into mitosis. Such breaks provide the substrate for translocations and deletions that are a hallmark of cancer

    On the Justifications for Civil Commitment

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    On the Justifications for Civil Commitment

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    A joint role for forced and internally-driven variability in the decadal modulation of global warming

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    Despite the observed monotonic increase in greenhouse-gas concentrations, global mean temperature displays important decadal fluctuations typically attributed to both external forcing and internal variability. Here, we provide a robust quantification of the relative contributions of anthropogenic, natural, and internally-driven decadal variability of global mean sea surface temperature (GMSST) by using a unique dataset consisting of 30-member large initial-condition ensembles with five Earth System Models (ESM-LE). We present evidence that a large fraction (~29–53%) of the simulated decadal-scale variance in individual timeseries of GMSST over 1950–2010 is externally forced and largely linked to the representation of volcanic aerosols. Comparison with the future (2010–2070) period suggests that external forcing provides a source of additional decadal-scale variability in the historical period. Given the unpredictable nature of future volcanic aerosol forcing, it is suggested that a large portion of decadal GMSST variability might not be predictable
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