Highly efficient crystal deflector for channeling extraction of a proton beam from accelerators

The design and performance of a novel crystal deflector for proton beams are reported. A silicon crystal was used to channel and extract 70 GeV protons from the U-70 accelerator in Protvino with an efficiency of 85%, as measured for a beam of ~1e12 protons directed towards crystals of ~2 mm length in spills of ~2 s duration. Experimental data agree with the theoretically predicted Monte Carlo results for channeling. The technique allows one to manufacture a very short deflector along the beam direction (2 mm). Consequently, multiple encounters of circulating particles with the crystal are possible with little probability of multiple scattering and nuclear interactions per encounter. Thus, drastic increase in efficiency for particle extraction out of the accelerator was attained. We show the characteristics of the crystal- deflector and the technology behind it. Such an achievement is important in devising a more efficient use of the U-70 accelerator and provides crucial support for implementing crystal-assisted slow extraction and collimation in other machines, such as the Tevatron, RHIC, the AGS, the SNS, COSY, and the LHC.Comment: Presented at PAC 2003 (Portland, May 12-16

Crystal Deflector for Highly-efficient Channelling Extraction of a Proton Beam from Accelerators

The design and manufacturing details of a new crystal deflector for proton beams are reported. The technique allows one to manufacture a very short deflector along the beam direction (2 mm). Thanks to that, multiple encounters of circulating particles with the crystal are possible with a reduced probability of multiple scattering and nuclear interactions per encounter. Thus, drastic increase in efficiency for particle extraction out of the accelerator was attained (85%) on a 70-GeV proton beam. We show the characteristics of the crystal-deflector and the technology behind it

Crystal Undulator As A Novel Compact Source Of Radiation

A crystalline undulator (CU) with periodically deformed crystallographic planes is capable of deflecting charged particles with the same strength as an equivalent magnetic field of 1000 T and could provide quite a short period L in the sub-millimeter range. We present an idea for creation of a CU and report its first realization. One face of a silicon crystal was given periodic micro-scratches (grooves), with a period of 1 mm, by means of a diamond blade. The X-ray tests of the crystal deformation have shown that a sinusoidal-like shape of crystalline planes goes through the bulk of the crystal. This opens up the possibility for experiments with high-energy particles channeled in CU, a novel compact source of radiation. The first experiment on photon emission in CU has been started at LNF with 800 MeV positrons aiming to produce 50 keV undulator photons.Comment: Presented at PAC 2003 (Portland, May 12-16

The Italian multiple sclerosis register

The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational studies based on register data, as they have the potential to answer the questions that are most relevant to daily treatment decision-making. In 2014, the Italian MS Foundation, in collaboration with the Italian MS clinical centers, promoted and funded the creation of the Italian MS Register, a project in continuity with the existing Italian MS Database Network set up from 2001. Main objective of the Italian MS Register is to create an organized multicenter structure to collect data of all MS patients for better defining the disease epidemiology, improving quality of care, and promoting research projects in high-priority areas. The aim of this article is to present the current framework and network of the Italian MS register, including the methodology used to improve the quality of data collection and to facilitate the exchange of data and the collaboration among national and international groups

The Italian multiple sclerosis register

The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational studies based on register data, as they have the potential to answer the questions that are most relevant to daily treatment decision-making. In 2014, the Italian MS Foundation, in collaboration with the Italian MS clinical centers, promoted and funded the creation of the Italian MS Register, a project in continuity with the existing Italian MS Database Network set up from 2001. Main objective of the Italian MS Register is to create an organized multicenter structure to collect data of all MS patients for better defining the disease epidemiology, improving quality of care, and promoting research projects in high-priority areas. The aim of this article is to present the current framework and network of the Italian MS register, including the methodology used to improve the quality of data collection and to facilitate the exchange of data and the collaboration among national and international groups

The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

In our study we describe the potency of established phosphoinositide-3-kinase (PI3K) and mammalian Target of Rapamycin (mTOR) kinase inhibitors against three trypanosomatid parasites: Trypanosoma brucei, T. cruzi, and Leishmania sp., which are the causative agents for African sleeping sickness, Chagas disease, and leishmaniases, respectively. We noted that these parasites and humans express similar kinase enzymes. Since these similar human targets have been pursued by the drug industry for many years in the discovery of cellular growth and proliferation inhibitors, compounds developed as human anti-cancer agents should also have effect on inhibiting growth and proliferation of the parasites. With that in mind, we selected eight established PI3K and mTOR inhibitors for profiling against these pathogens. Among these inhibitors is an advanced clinical candidate against cancer, NVP-BEZ235, which we demonstrate to be a highly potent trypanocide in parasite cultures, and in a mouse model of T. brucei infection. Additionally, we describe observations of these inhibitors' effects on parasite growth and other cellular characteristics

Atrial Flutter in Patient With Critical COVID-19: Beneficial Effects of Rhythm Control on Respiratory Distress

We report the case of a patient critically ill with coronavirus disease–2019 (COVID-19) in which atrial flutter with high ventricular response rate occurred, contributing to worsening of the respiratory distress. After failure of noninvasive rate and rhythm control strategies, successful transcatheter ablation was performed and the respiratory distress of the patient improved. (Level of Difficulty: Beginner.

Multiscale computational modeling of size effects in carbon nanotube-polymer composites

The development of carbon nanotube(CNT)-polymer composites advocates for a better understanding of their physical and mechanical properties that depend on the diameter of the embedded CNTs. Given that the experimental assessment of size effects is extremely difficult, the use of numerical models can be enormously helpful. However, since size effects might be observed both at the nano- and the macroscale, an adequate multiscale procedure is required.In this thesis, numerical techniques are explored to develop a multiscale approach for the analysis of size effects in the elastic response of CNT-polymer composites. Atomistic simulations, such a molecular mechanics and molecular dynamics, are used for the characterization of the composites and their components at the nanoscale. The obtained results are then used to investigate size effects in the macroscopic properties of CNT-polymer composites using continuum models and efficient finite element techniques.Molecular mechanics simulations on tensile carbon nanotubes show that their axial stiffness and axial strain field depend on the CNT diameter. Moreover, it is found that the axial strain field can be accurately reproduced using nonlocal continuum models if optimal nonlocal parameters, that vary with the nanotube diameter, and a suitable nonlocal kernel are used.Although the numerical solution of nonlocal problems is typically challenging, higher order B-spline finite elements overcome the issues encountered when standard approximation techniques are employed. Further, molecular dynamics simulations on CNT-polymer composites show that the CNT diameter alters the atomic structure and the mechanical properties of the ordered layer of polymer chains forming around the nanotube —the interphase. Such a layer has a significant impact on the mechanical properties of the composite. Although the role of the nanotubes during elastic deformation of the composite is negligible due to the weak nonbonded interface interactions, the interphase–thanks to its highly ordered atomic structure–is shown to enhance its mechanical properties. Here, molecular mechanics simulations at the nanoscale and the numerical solution of an equivalent continuum model at the macroscale indicate that the composite stiffness increases when the diameter of the carbon nanotubes is decreased.When possible, the reliability of the results in this thesis has been assessed by means of analytical models and experimental or numerical results in the literature. Therefore, this study proposes a computational framework to improve our understanding of the mechanical response of CNT-polymer composites and the size effects on their elastic properties.Applied Mechanic