CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors

<p>Abstract</p> <p>Background</p> <p>Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies.</p> <p>Methods</p> <p>We screened for TICs in 47 human adult brain malignant tumors. Cells forming floating spheres in culture, and endowed with all of the features expected from tumor cells with stem-like properties were obtained from glioblastomas, medulloblastoma but not oligodendrogliomas.</p> <p>Results</p> <p>A long-term self-renewal capacity was particularly observed for cells of malignant glio-neuronal tumors (MGNTs). Cell sorting, karyotyping and proteomic analysis demonstrated cell stability throughout prolonged passages. Xenografts of fewer than 500 cells in Nude mouse brains induced a progressively growing tumor. CD133, CD15/LeX/Ssea-1, CD34 expressions, or exclusion of Hoechst dye occurred in subsets of cells forming spheres, but was not predictive of their capacity to form secondary spheres or tumors, or to resist high doses of temozolomide.</p> <p>Conclusions</p> <p>Our results further highlight the specificity of a subset of high-grade gliomas, MGNT. TICs derived from these tumors represent a new tool to screen for innovative therapies.</p

Boundary value problem for elliptic differential equations in non-commutative cases

We consider a boundary value problem for elliptic differential equations in non-commutative case

Elliptic problems with robin boundary coefficient-operator conditions in general L&lt;sup&gt;p&lt;/sup&gt; sobolev spaces and applications

In this paper we prove some new results on complete operational second order differential equations of elliptic type with coeficient-operator conditions, in the framework of the space Lp(0; 1;X) with general p 08 (1;+ 1e), X being a UMD Banach space. Existence, uniqueness and optimal regularity of the classical solution are proved. This paper improves and completes naturally our last two works on this problematic

Complete abstract differential equations of elliptic type with general Robin boundary conditions, in UMD spaces

In this paper we prove some new results concerning a complete abstract second-order differential equation with general Robin boundary conditions. The study is developped in UMD spaces and uses the celebrated Dore-Venni Theorem. We prove existence, uniqueness and maximal regularity of the strict solution. This work completes previous one [3] by authors; see also [11]

Abstract differential equations of elliptic type with general Robin boundary conditions in Hoelder spaces

In this article, we prove some new results on abstract second-order differential equations of elliptic type with general Robin boundary conditions. The study is performed in Holder spaces and uses the well-known Da Prato-Grisvard sum theory. We give necessary and sufficient conditions on the data to obtain a unique strict solution satisfying the maximal regularity property. This work completes the ones studied by Favini et al. [A. Favini, R. Labbas, S. Maingot, H. Tanabe, and A. Yagi, Necessary and sufficient conditions in the study of maximal regularity of elliptic differential equations in Holder spaces, Discrete Contin. Dyn. Syst. 22 (2008), pp. 973-987] and Cheggag et al. [M. Cheggag, A. Favini, R. Labbas, S. Maingot and A. Medeghri, Sturm-Liouville problems for an abstract differential equation of elliptic type in UMD spaces, Differ. Int. Eqns 21(9-10) (2008), pp. 981-1000]

NEW results on complete elliptic equations With robin boundary coefficient-operator conditions in non commutative case

In this paper, we prove some new results on operational second order differential equations of elliptic type with general Robin boundary conditions in a non-commutative framework. The study is performed when the second member belongs to a Sobolev space. Existence, uniqueness and optimal regularity of the classical solution are proved using interpolation theory and results on the class of operators with bounded imaginary powers. We also give an example to which our theory applies. This paper improves naturally the ones studied in the commutative case by M. Cheggag, A. Favini, R. Labbas, S. Maingot and A. Medeghri: in fact, introducing some operational commutator, we generalize the representation formula of the solution given in the commutative case and prove that this representation has the desired regularity