651 research outputs found
Applying genetic algorithms to convoy scheduling
We present the results of our work on applying genetic algorithms combined with a discrete event simulation to the problem of convoy scheduling. We show that this approach can automatically remove conflicts from a convoy schedule thereby providing to the human operator the ability to search for better solutions after an initial conflict free schedule is obtained. We demonstrate that it is feasible to find a conflict free schedule for realistic problems in a few minutes on a common workstation or laptop. The system is currently being integrated into a larger Transportation Information System that regulates highway movement for the militaryIFIP International Conference on Artificial Intelligence in Theory and Practice - Industrial Applications of AIRed de Universidades con Carreras en Informática (RedUNCI
Applying genetic algorithms to convoy scheduling
We present the results of our work on applying genetic algorithms combined with a discrete event simulation to the problem of convoy scheduling. We show that this approach can automatically remove conflicts from a convoy schedule thereby providing to the human operator the ability to search for better solutions after an initial conflict free schedule is obtained. We demonstrate that it is feasible to find a conflict free schedule for realistic problems in a few minutes on a common workstation or laptop. The system is currently being integrated into a larger Transportation Information System that regulates highway movement for the militaryIFIP International Conference on Artificial Intelligence in Theory and Practice - Industrial Applications of AIRed de Universidades con Carreras en Informática (RedUNCI
POWTEX Neutron Diffractometer at FRM II - new perspectives for in-situ rock deformation analysis
EGU2012-13521
In Geoscience quantitative texture analysis here defined as the quantitative analysis of the crystallographic preferred orientation (CPO), is a common tool for the investigation of fabric development in mono- and polyphase rocks, their deformation histories and kinematics. Bulk texture measurements also allow the quantitative characterisation of the anisotropic physical properties of rock materials. A routine tool to measure bulk sample volumes is neutron texture diffraction, as neutrons have large penetration capabilities of several cm in geological sample materials.
The new POWTEX (POWder and TEXture) Diffractometer at the neutron research reactor FRM II in Garching, Germany is designed as a high-intensity diffractometer by groups from the RWTH Aachen, Forschungszentrum Jülich and the University of Göttingen. Complementary to existing neutron diffractometers (SKAT at Dubna, Russia; GEM at ISIS, UK; HIPPO at Los Alamos, USA; D20 at ILL, France; and the local STRESS-SPEC and SPODI at FRM II) the layout of POWTEX is focused on fast time-resolved experiments and the measurement of larger sample series as necessary for the study of large scale geological structures. POWTEX is a dedicated beam line for geoscientific research.
Effective texture measurements without sample tilting and rotation are possible firstly by utilizing a range of neutron wavelengths simultaneously (Time-of-Flight technique) and secondly by the high detector coverage (9.8 sr) and a high flux (�~1x10 7 n/cm2s) at the sample. Furthermore the instrument and the angular detector resolution is designed also for strong recrystallisation textures as well as for weak textures of polyphase rocks. These instrument characteristics allow in-situ time-resolved texture measurements during deformation experiments on rocksalt, ice and other materials as large sample environments will be implemented at POWTEX.
The in-situ deformation apparatus is operated by a uniaxial spindle drive with a maximum axial load of 250 kN, which will be redesigned to minimize shadowing effects inside the cylindrical detector. The HT deformatione experiments will be carried out in uniaxial compression or extension and an upgrade to triaxial deformation conditions is envisaged. The load frame can alternatively be used for ice deformation by inserting a cryostat cell for temperatures down to 77 K with a triaxial apparatus allowing also simple shear experiments on ice. Strain rates range between 10-8 and 10-3 s-1 reaching to at least 50% axial strain. The deformation apparatus is designed for continuous long-term deformation experiments and can be exchanged between in-situ and ex-situ placements during continuous operation inside and outside the neutron detector
Measurement of calcite crystallographic-preferred orientations by magnetic anisotropy and comparison to diffraction methods
The anisotropy of magnetic susceptibility
(AMS) of rocks reflects the preferred
orientations of minerals. Therefore
AMS is a quick and easy way to
characterize rock fabrics (Hrouda 1982,Borradaile 1988); the obtained result is also called the magnetic fabric of the
rock. The method has been often used
to measure the orientation of ferromagnetic
minerals, mainly magnetite, but in
recent studies it has been increasingly
used to measure textures of paramagnetic
minerals as phyllosilicates (Lüneburg
et al. 1999, Cifelli et al. 2004).
A further application is the measurement of
diamagnetic textures, especially calcite
textures. Calcite is suitable for the AMS
method, because it has a high magnetic
anisotropy with the minimum susceptibility
along the crystallographic c-axis.
Therefore a preferred orientation of the
c-axes, which can be induced by deformation,
generates a magnetic fabric...conferenc
Correlation of magnetic fabric and crystallographic preferred orientations of naturally deformed carbonate — mica rocks from the Alpi Apuane in Italy and the Damara Orogen in Namibia
The anisotropy of magnetic susceptibility
(AMS) is a time-efficient method to
describe crystallographic preferred orientations
of rocks and has been applied
in a wide field of sedimentary, metamorphic
and magmatic geology. The method, however, suffers from limitations
which mainly result from the
interference of diamagnetic, paramagnetic
and ferromagnetic fabrics (de Wall
2005) — the term ferromagnetism is
used in a wider sense here, including e.g.
ferrimagnetism. The AMS is an integral
parameter which describes a crystallographic
preferred orientation as an ellipsoid.
The quantitative correlation of
the AMS with the crystallographic preferred
orientations should help to allow
a closer view at the applicability and the
limitations of the AMS analysis (see also
Schmidt et al. 2006 a, b)...
The results of this study are based
on a large variety of fabric types of
carbonate-mica marbles and mylonites,
i.e. varying mica content, grain sizes,
grain shapes, types and intensities of
the crystallographic preferred orientation.
The presented first correlations of
the AMS and CPO for the single mineral
phases in general demonstrate a good
matching. Regarding the comparison of
texture types and the AMS, limitations
are possible. While single c-axis maxima
and girdle-like c-axis distributions
can be also distinguished by the AMS,
it is obvious that distinguishing between
these types and the double c-axis type
is not possible at the present stage.conferenc
Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis. Platelet-expressed Gαi2 is decisive for the extent of tissue injury following ischemia/reperfusion. However, it is not known whether Gαi2 plays a role in the regulation of platelet apoptosis, which is characterized by caspase activation, cell shrinkage and cell membrane scrambling with phosphatidylserine (PS) translocation to the platelet surface. Stimulators of platelet apoptosis include thrombin and collagen-related peptide (CoRP), which are further known to enhance degranulation and activation of αII bβ3-integrin and caspases. Using FACS analysis, we examined the impact of agonist treatment on activation and apoptosis in platelets drawn from mice lacking Gαi2 and their wild-type (WT) littermates. As a result, treatment with either thrombin (0.01 U/mL) or CoRP (2 μg/mL or 5 μg/mL) significantly upregulated PS-exposure and significantly decreased forward scatter, reflecting cell size, in both genotypes. Exposure to CoRP triggered a significant increase in active caspase 3, ceramide formation, surface P-selectin, and αII bβ3-integrin activation. These molecular alterations were significantly less pronounced in Gαi2-deficient platelets as compared to WT platelets. In conclusion, our data highlight a previously unreported role of Gαi2 signaling in governing platelet activation and apoptosis.Fil: Cao, Hang. Universität Tübingen; AlemaniaFil: Qadri, Syed M.. Canadian Blood Services; Canadá. McMaster University; CanadáFil: Lang, Elisabeth. Heinrich-heine-universität Düsseldorf; AlemaniaFil: Pelzl, Lisann. Universität Tübingen; AlemaniaFil: Umbach, Anja T.. Universität Tübingen; AlemaniaFil: Leiss, Veronika. Universität Tübingen; AlemaniaFil: Birnbaumer, Lutz. National Institutes of Health; Estados Unidos. Pontificia Universidad Católica Argentina "Santa MarÃa de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Nürnberg, Bernd. Universität Tübingen; AlemaniaFil: Pieske, Burkert. Berlin Institute of Health; Alemania. Universitätsmedizin Berlin; AlemaniaFil: Voelkl, Jakob. Berlin Institute of Health; Alemania. Universitätsmedizin Berlin; AlemaniaFil: Gawaz, Meinrad. Universität Tübingen; AlemaniaFil: Bissinger, Rosi. Universität Tübingen; AlemaniaFil: Lang, Florian. Universität Tübingen; Alemania. Heinrich-heine-universität Düsseldorf; Alemani
Applying genetic algorithms to convoy scheduling
We present the results of our work on applying genetic algorithms combined with a discrete event simulation to the problem of convoy scheduling. We show that this approach can automatically remove conflicts from a convoy schedule thereby providing to the human operator the ability to search for better solutions after an initial conflict free schedule is obtained. We demonstrate that it is feasible to find a conflict free schedule for realistic problems in a few minutes on a common workstation or laptop. The system is currently being integrated into a larger Transportation Information System that regulates highway movement for the militaryIFIP International Conference on Artificial Intelligence in Theory and Practice - Industrial Applications of AIRed de Universidades con Carreras en Informática (RedUNCI
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