On the evolution of snow roughness during snow fall

The deposition and attachment mechanism of settling snow crystals during snowfall dictates the very initial structure of ice within a natural snowpack. In this letter we apply ballistic deposition as a simple model to study the structural evolution of the growing surface of a snowpack during its formation. The roughness of the snow surface is predicted from the behaviour of the time dependent height correlation function. The predictions are verified by simple measurements of the growing snow surface based on digital photography during snowfall. The measurements are in agreement with the theoretical predictions within the limitations of the model which are discussed. The application of ballistic deposition type growth models illuminates structural aspects of snow from the perspective of formation which has been ignored so far. Implications of this type of growth on the aerodynamic roughness length, density, and the density correlation function of new snow are discusse

The Barrier Method: A Technique for Calculating Very Long Transition Times

In many dynamical systems there is a large separation of time scales between typical events and "rare" events which can be the cases of interest. Rare-event rates are quite difficult to compute numerically, but they are of considerable practical importance in many fields: for example transition times in chemical physics and extinction times in epidemiology can be very long, but are quite important. We present a very fast numerical technique that can be used to find long transition times (very small rates) in low-dimensional systems, even if they lack detailed balance. We illustrate the method for a bistable non-equilibrium system introduced by Maier and Stein and a two-dimensional (in parameter space) epidemiology model.Comment: 20 pages, 8 figure

A genotypic trade-off between constitutive resistance to viral infection and host growth rate

This is the final version. Available on open access from Wiley via the DOI in this record.All data used in this study are made available in the supplementary informationGenotypic trade-offs are fundamental to the understanding of the evolution of life-history traits. In particular, the evolution of optimal host defence and the maintenance of variation in defence against infectious disease is thought to be underpinned by such evolutionary trade-offs. However, empirical demonstrations of these trade-offs that satisfy the strict assumptions made by theoretical models are rare. Additionally, none of these trade-offs have yet been shown to be robustly replicable using a variety of different experimental approaches to rule out confounding issues with particular experimental designs. Here, we use inbred isolines as a novel experimental approach to test whether a trade-off between viral resistance and growth rate in Plodia interpunctella, previously demonstrated by multiple selection experiments, is robust and meets the strict criteria required to underpin theoretical work in this field. Critically, we demonstrate that this trade-off is both genetic and constitutive. This finding helps support the large body of theory which relies on these assumptions, and makes this trade-off for resistance unique in being replicated through multiple experimental approaches and definitively shown to be genetic and constitutive

Further studies of the coupled chemically reacting boundary layer and charring ablator. Part 1 - Summary Final report

Computer program development for charring ablative materials, chemically reacting laminar boundary layers, and turbulent boundary layer initiatio

Treatment of multidrug-resistant tuberculosis in a remote, conflict-affected area of the Democratic Republic of Congo.

The Democratic Republic of Congo is a high-burden country for multidrug-resistant tuberculosis. Médecins Sans Frontières has supported the Ministry of Health in the conflict-affected region of Shabunda since 1997. In 2006, three patients were diagnosed with drug-resistant TB (DR-TB) and had no options for further treatment. An innovative model was developed to treat these patients despite the remote setting. Key innovations were the devolving of responsibility for treatment to non-TB clinicians remotely supported by a TB specialist, use of simplified monitoring protocols, and a strong focus on addressing stigma to support adherence. Treatment was successfully completed after a median of 24 months. This pilot programme demonstrates that successful treatment for DR-TB is possible on a small scale in remote settings

MACiE: a database of enzyme reaction mechanisms.

SUMMARY: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create a classification system which reflects the actual chemical mechanism (catalytic steps) of an enzyme reaction, not only the overall reaction. AVAILABILITY: http://www-mitchell.ch.cam.ac.uk/macie/.EPSRC (G.L.H. and J.B.O.M.), the BBSRC (G.J.B. and J.M.T.—CASE studentship in association with Roche Products Ltd; N.M.O.B. and J.B.O.M.—grant BB/C51320X/1), the Chilean Government’s Ministerio de Planificacio´n y Cooperacio´n and Cambridge Overseas Trust (D.E.A.) for funding and Unilever for supporting the Centre for Molecular Science Informatics.application note restricted to 2 printed pages web site: http://www-mitchell.ch.cam.ac.uk/macie

Adaptive Measurements in the Optical Quantum Information Laboratory

Adaptive techniques make practical many quantum measurements that would otherwise be beyond current laboratory capabilities. For example: they allow discrimination of nonorthogonal states with a probability of error equal to the Helstrom bound; they allow measurement of the phase of a quantum oscillator with accuracy approaching (or in some cases attaining) the Heisenberg limit; and they allow estimation of phase in interferometry with a variance scaling at the Heisenberg limit, using only single qubit measurement and control. Each of these examples has close links with quantum information, in particular experimental optical quantum information: the first is a basic quantum communication protocol; the second has potential application in linear optical quantum computing; the third uses an adaptive protocol inspired by the quantum phase estimation algorithm. We discuss each of these examples, and their implementation in the laboratory, but concentrate upon the last, which was published most recently [Higgins {\em et al.}, Nature vol. 450, p. 393, 2007].Comment: 12 pages, invited paper to be published in IEEE Journal of Selected Topics in Quantum Electronics: Quantum Communications and Information Scienc