27 research outputs found
Results from a large targeted screening program for alpha-1-antitrypsin deficiency: 2003 - 2015
Insights into the Structure and Function of a Chiral Conjugate‐Base‐Stabilized Brønsted Acid Catalyst
Zwitterionic imidazolium salt: An efficient organocatalyst for tetrahydropyranylation of alcohols
Cooperative Thiourea–Brønsted Acid Organocatalysis: Enantioselective Cyanosilylation of Aldehydes with TMSCN
We report a new thiourea–Brønsted acid cooperative
catalytic system for the enantioselective cyanosilylation of aldehydes
with yields up to 90% and enantioselectivities up to 88%. The addition
of an achiral acid was found to be crucial for high asymmetric induction.
Mechanistic investigations using a combination of NMR, ESI-MS, and
density functional theory computations (including solvent corrections) at the M06/6-31G(d,p) level of theory
suggest that the key catalytic species results from the cooperative
interaction of bifunctional thioureas and an achiral acid that form
well-defined chiral hydrogen-bonding environments