27 research outputs found
Results from a large targeted screening program for alpha-1-antitrypsin deficiency: 2003 - 2015
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Insights into the Structure and Function of a Chiral Conjugate‐Base‐Stabilized Brønsted Acid Catalyst
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Zwitterionic imidazolium salt: An efficient organocatalyst for tetrahydropyranylation of alcohols
No full textCooperative Thiourea–Brønsted Acid Organocatalysis: Enantioselective Cyanosilylation of Aldehydes with TMSCN
No full textWe report a new thiourea–Brønsted acid cooperative
catalytic system for the enantioselective cyanosilylation of aldehydes
with yields up to 90% and enantioselectivities up to 88%. The addition
of an achiral acid was found to be crucial for high asymmetric induction.
Mechanistic investigations using a combination of NMR, ESI-MS, and
density functional theory computations (including solvent corrections) at the M06/6-31G(d,p) level of theory
suggest that the key catalytic species results from the cooperative
interaction of bifunctional thioureas and an achiral acid that form
well-defined chiral hydrogen-bonding environments
Accelerating Amine‐Catalyzed Asymmetric Reactions by Intermolecular Cooperative Thiourea/Oxime Hydrogen‐Bond Catalysis
No full textUrea derivatives are highly active catalysts for the base-mediated generation of terminal epoxides from aldehydes and trimethylsulfonium iodide
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