TENOFOVIR INDUCED SEVERE LACTIC ACIDOSIS AND HEPATITIS

Tenofovir induced hepatitis and severe lactic acidosis is rare. We report a rare case of tenofovir causing hepatitis in severe lactic acidosis in a seropositive patient with none of the identifiable risk factor. A 50 years old seropositive male on ZLN (Zidovudine, Lamivudine, Nevirapine) regimen since 3 years admitted under medicine care with complaints of weakness, fatigability and giddiness since 1 month. All investigations were normal apart from hemoglobin which was 4.5 gm/dL. ART regimen was changed to TLE (Tenofovir, Lamivudine, Efavirenz). After 3 days, patient had nausea, vomiting, upper abdominal pain and breathlessness. Investigations showed aspartate transaminase was 2400 IU/L, alanine transaminase 2706 IU/L, serum bilirubin 0.6 mg/dL, alkaline phosphatase 108 IU/L, PT 14 sec, INR 1.4, serum urea 16 mg/dL and serum creatinine 0.8 mg/dL. Arterial blood gas evaluation showed pH 6.96, PaO 2 116, PaCO2 12, HCO3 1.6. Serum lactate levels were 42 mg/dl. Viral markers were negative. Diagnosis of tenofovir induced hepatitis and lactic acidosis was made. Patient improved after stopping Tenofovir

Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria

Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns

Synthesis of isoxazoles and quinoxalines as potential anticancer agents

421-4242-Acetylbenzimidazole on condensation with various aldehydes yield chalcones 1 which on cyclisation with hydroxylaminehydrochloride in sodium acetate furnish 3-(benzimidazol-2'-yl)-5-arylisoxazoles 2a-1. Dibromo derivative of chalcones 1 on reaction with 2-phenylene diamine in sulphuric acid furnish 2-(benzimidazol-2'-yl-methyl)-3-arylquinoxalines 3a-1. The structure of the compounds 3a-1 have been confirmed from elemental analyses, IR, 1H NMR and mass spectral data. The purity of the synthesised compounds have been checked by thin layer chromatography and screened for their antimicrobial and anticancer activity. All the products have been evaluated for their in vitro growth inhibitory activity against different microbes

Smart Solar Power Inverter: Solar Power Systems, Inverters, Photovoltaic, Internet of Things (IoT).

 The growth of the solar market over the past few years has been remarkable, with the increase in total number of installations of photovoltaic plants worldwide. The impact of this ever growing clean and efficient renewable energy generation makes it imperative that the grid infrastructure become more resilient and smart to produce uninterrupted flow of electricity. The research paper focuses on two main aspects viz. generation of electricity through solar energy and secondly connecting wireless communications to monitor the solar power inverter. The solar based inverter circuit along with Internet of Things (IoT) interfaced level indicator circuit. To indicate the amount of charge left and time consumption depending upon different load usage IoT devices are used to monitor

Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for their in vitroin vitro antimicrobial activity