Isotopic Composition of the Solar Wind Inferred from In-Situ Spacecraft Measurements

The Sun is the largest reservoir of matter in the solar system, which formed 4.6Gyr ago from the protosolar nebula. Data from space missions and theoretical models indicate that the solar wind carries a nearly unfractionated sample of heavy isotopes at energies of about 1keV/amu from the Sun into interplanetary space. In anticipation of results from the Genesis mission's solar-wind implanted samples, we revisit solar wind isotopic abundance data from the high-resolution CELIAS/MTOF spectrometer on board SOHO. In particular, we evaluate the isotopic abundance ratios 15N/14N, 17O/16O, and 18O/16O in the solar wind, which are reference values for isotopic fractionation processes during the formation of terrestrial planets as well as for the Galactic chemical evolution. We also give isotopic abundance ratios for He, Ne, Ar, Mg, Si, Ca, and Fe measured in situ in the solar win

Measurement and Analysis of the Extreme Physical Shock Environment Experienced by Crane-Mounted Radiation Detection Systems

At ports of entry, radiation detectors could be mounted on container gantry crane spreaders to monitor cargo containers entering and leaving the country. These detectors would have to withstand the extreme physical conditions experienced by these spreaders during normal operations. Physical shock data from the gable ends of a spreader were recorded during the loading and unloading of a cargo ship by two hard mounted PCB Piezotronics model 340A50 accelerometers and two Lansmont SAVER 9X30 units (with padding). The majority of large shocks were observed in the vertical direction. The Lansmont units recorded mean shocks of 22.215 ± 1.174 and 23.776 ± 1.140 g, while the PCB accelerometers recorded mean shocks of 31.608 ± 1.798 and 37.072 ± 2.015 g in this direction. Maximum shocks were as high as 118.854 g. A scatter plot of observed peak acceleration versus velocity change is presented to allow comparison with the damage boundary curve for any planned instrumentation for future systems. It is hoped that the results of this research will aid in the design of future crane-mounted systems

Improved measurements of ICRF antenna input impedance at ASDEX upgrade during ICRF coupling studies

A new set of diagnostics has been implemented on ASDEX Upgrade to measure the input impedance of the ICRF antennas, in the form of a voltage and current probe pair installed on each feeding line of every antenna. Besides allowing the measurement of the reflection coefficient Gamma of each antenna port, the probes have two advantages: first, they are located close to the antenna ports (similar to 3 m) and thus the measurements are not affected by the uncertainties due to the transmission and matching network; second, they are independent of matching conditions. These diagnostics have been used to study the behavior of the ASDEX Upgrade antennas while changing the plasma shape (low to high triangularity) and applying magnetic perturbations (MPs) via saddle coils. Scans in the separatrix position R-sep were also performed. Upper triangularity delta(o) was increased from 0.1 to 0.3 (with the lower triangularity delta(o) kept roughly constant at 0.45) and significant decreases in vertical bar Gamma vertical bar (up to similar to 30%, markedly improving antenna coupling) and moderate changes in phase (up to similar to 5 degrees) off on each feeding line were observed approximately at delta(o) >= 0.29. During MPs (in similar to 0.5 s pulses with a coil current of 1 kA), a smaller response was observed: 6% - 7% in vertical bar Gamma vertical bar, with changes in phase of 5 apparently due to R p scans only. As 1 is usually in the range 0.8 - 0.9, this still leads to a significant increase in possible coupled power. Numerical simulations of the antenna behavior were carried out using the FELICE code; the simulation results are in qualitative agreement with experimental measurements. The results presented here complement the studies on the influence of gas injection and MPs on the ICRF antenna performance presented in [4]

Etoposid im Neuroblastomprotokoll:eine PBPK-basierte Auswertung relevanter Einflussfaktoren und Dosierungsregime

Ziel der Arbeit ist die Untersuchung von Einflussgrößen auf die Pharmakokinetik von Etoposid in einer pädiatrischen Kohorte. Mithilfe der physiologiebasierten Pharmakokinetik (Software PK-Sim®, BTS) wurden Daten von 38 Patienten mit 127 Etoposidmesswerten ausgewertet. Individuelle Simulationen konnten die gemessenen Spiegel nur ungenügend wiedergeben. Eine populations-pharmakokinetische Simulation erzeugte eine identische Plasmaspiegelverteilung im Vergleich zur Kohorte. Auf die Simulationsergebnisse zeigte die freie Fraktion den größten Einfluss, mehr als renale und hepatische Funktion oder die Körperzusammensetzung. Das Modell konnte höhere Etoposidspiegel bei adipösen Patienten bestätigen. Eine Dosierung nach Körpergewicht senkte die interindividuelle Variabilität im Vergleich zu einer fixen Dosis nach Alter nicht. Auch für Kleinkinder lag eine ausreichende Therapiesicherheit bei Dosierung nach m² KOF vor. Ein Drugmonitoring sollte bei adipösen Patienten in Betracht gezogen werden

Sex ratio of mirid populations shifts in response to hostplant co-infestation or altered cytokinin signaling

Herbivore species sharing a host plant often compete. In this study, we show that host plant-mediated interaction between two insect herbivores – a generalist and a specialist – results in a sex ratio shift of the specialist's offspring. We studied demographic parameters of the specialist Tupiocoris notatus (Hemiptera: Miridae) when co-infesting the host plant Nicotiana attenuata (Solanaceae) with the generalist leafhopper Empoasca sp. (Hemiptera: Cicadellidae). We show that the usually female-biased sex ratio of T. notatus shifts toward a higher male proportion in the offspring on plants co-infested by Empoasca sp. This sex ratio change did not occur after oviposition, nor is it due differential mortality of female and male nymphs. Based on pyrosequencing and PCR of bacterial 16S rRNA amplicons, we concluded that sex ratio shifts were unlikely to be due to infection with Wolbachia or other known sex ratio- distorting endosymbionts. Finally, we used transgenic lines of N. attenuata to evaluate if the sex ratio shift could be mediated by changes in general or specialized host plant metabolites. We found that the sex ratio shift occurred on plants deficient in two cytokinin receptors (irCHK2/3). Thus, cytokinin-regulated traits can alter the offspring sex ratio of the specialist T. notatus

Functional variation in a key defense gene structures herbivore communities and alters plant performance

Plant genetic diversity structures animal communities and affects plant population productivity. However, few studies have investigated which traits are involved and the mechanisms mediating these effects. We studied the consequences of varying the expression of a single biosynthetic gene in jasmonate (JA) defense hormones, which are essential for defense against herbivores but constrain plant growth, in experimental mesocosm populations of wild tobacco (Nicotiana attenuata) plants under attack from three native herbivores. Empoasca leafhoppers preferentially attack JA-deficient N. attenuata plants in nature, and the specialist Tupiocoris notatus mirids avoid Empoasca-damaged plants. However, in experimental mesocosm populations having equal numbers of wild-type (WT) and JA-deficient plants that are silenced in the expression of the biosynthetic gene lipoxygenase 3 (LOX3), Empoasca sp. attacked both genotypes. Empoasca sp. damage, rather than JA, determined T. notatus damage, which was reduced in mixed populations. The growth of specialist Manduca sexta larvae was reduced on WT vs. asLOX3 monocultures, but differed in mixtures depending on caterpillar density. However, seed capsule number remained similar for WT and asLOX3 plants in mixtures, not in monocultures, in two experimental scenarios reflecting high and low caterpillar attack. At high caterpillar density, WT plants growing in mixtures produced more seed capsules than those growing in monocultures while seed production of asLOX3 plants did not differ by population type. However, at low caterpillar density, asLOX3 plants growing in mixed populations produced more seed capsules than those growing in monoculture, while seed capsule production did not differ for WT by population type. Thus, mixed populations had a more stable output of seed capsules under the two scenarios. This may result from a balance between JA-mediated herbivore defense and plant competitive ability in mixed populations

Isotopic Composition of Solar Wind Calcium: First in Situ Measurement by CELIAS/MTOF on Board SOHO

We present first results on the Ca isotopic abundances derived from the high resolution Mass Time-of-Flight (MTOF) spectrometer of the charge, element, and isotope analysis system (CELIAS) experiment on board the Solar and Heliospheric Observatory (SOHO). We obtain isotopic ratios 40Ca/42Ca = (128+-47) and 40Ca/44Ca = (50+-8), consistent with terrestrial values. This is the first in situ determination of the solar wind calcium isotopic composition and is important for studies of stellar modeling and solar system formation since the present-day solar Ca isotopic abundances are unchanged from their original isotopic composition in the solar nebula.Comment: 14 pages, 3 figure