Bone Health and Risk Factors of Cardiovascular Disease - A Cross-Sectional Study in Healthy Young Adults

Peer reviewe

Infant milk feeding influences adult bone health: A prospective study from birth to 32 years

Peer reviewe

BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.

Interstitial lung disease (ILD) is a complex and heterogeneous disorder that is often associated with autoimmune syndromes. Despite the connection between ILD and autoimmunity, it remains unclear whether ILD can develop from an autoimmune response that specifically targets the lung parenchyma. We examined a severe form of autoimmune disease, autoimmune polyglandular syndrome type 1 (APS1), and established a strong link between an autoimmune response to the lung-specific protein BPIFB1 (bactericidal/permeability-increasing fold-containing B1) and clinical ILD. Screening of a large cohort of APS1 patients revealed autoantibodies to BPIFB1 in 9.6% of APS1 subjects overall and in 100% of APS1 subjects with ILD. Further investigation of ILD outside the APS1 disorder revealed BPIFB1 autoantibodies present in 14.6% of patients with connective tissue disease-associated ILD and in 12.0% of patients with idiopathic ILD. The animal model for APS1, Aire⁻/⁻ mice, harbors autoantibodies to a similar lung antigen (BPIFB9); these autoantibodies are a marker for ILD. We found that a defect in thymic tolerance was responsible for the production of BPIFB9 autoantibodies and the development of ILD. We also found that immunoreactivity targeting BPIFB1 independent of a defect in Aire also led to ILD, consistent with our discovery of BPIFB1 autoantibodies in non-APS1 patients. Overall, our results demonstrate that autoimmunity targeting the lung-specific antigen BPIFB1 may contribute to the pathogenesis of ILD in patients with APS1 and in subsets of patients with non-APS1 ILD, demonstrating the role of lung-specific autoimmunity in the genesis of ILD

Allergy from infancy to adolescence. A population-based 18-year follow-up cohort

<p>Abstract</p> <p>Background</p> <p>Anxious parents have many concerns about the future health of their atopic infants. Paediatricians and primary care practitioners need to seek knowledge on long-term outcomes in order to cope with the increasing caseload of suspected allergy and the concerns of parents. The aim of the study was to assess suspected and diagnosed allergy in infancy as predictors of allergy and asthma in adolescence.</p> <p>Methods</p> <p>Families expecting their first baby and making their first visit to a maternity health care clinic in 1986 were selected as the study population in a random sample. There were 1278 eligible study families. The data were provided of the children at the ages of 9 and 18 months and 3, 5, 12, 15 and 18 years by health care professionals, parents, and adolescents (themselves).</p> <p>Results</p> <p>At the age of 9 months, the prevalence of allergy suspicions was distinctly higher than that of allergy diagnoses. At the age of five years suspected allergy approaches were nil, and the prevalence of diagnosed allergy was about 9%. During the adolescence, the prevalence of self-reported allergy increases steadily up to the age of 18 years, and that of asthma remains at approximately 5%. Suspected allergy at the age of 9 or 18 months and at the 5 years of age does not predict allergy at adolescence. Compared with non-allergic children, children with definite allergy at the age of 5 were over 8 times more likely to have allergy and nearly 7 times more likely to have asthma in adolescence.</p> <p>Conclusion</p> <p>An early ascertained diagnosis of allergy, but not suspicions of allergy, predicts prevailing allergy in adolescence. Efforts need to be focused on accurate diagnosis of early childhood allergies.</p

Coping With Crisis : Green Space Use in Helsinki Before and During the COVID-19 Pandemic

Funding Information: The datasets used in this study were collected under a Plan-H project funded by Academy of Finland grant number 13297753. Publisher Copyright: Copyright © 2021 Korpilo, Kajosaari, Rinne, Hasanzadeh, Raymond and Kyttä.The COVID-19 pandemic has encouraged a deeper exploration about how people deal with crisis. This paper presents one of the first pre- and during-pandemic assessments of urban green infrastructure (UGI) use across the same individuals with the aim of better understanding how people's use of different types of urban green and blue spaces changed during the pandemic. A baseline Public Participation GIS survey (N = 1,583 respondents) conducted in August 2018 was followed up in May 2020 (N = 418 identical respondents) during the COVID-19 pandemic in Helsinki, Finland. We found that residents were more likely to visit UGI closer to their home during the pandemic compared with before the pandemic. Patterns of use of UGI were associated with the quality of residential green areas, for example, people sought out forests nearby one's domicile and tended to avoid parks and recreation areas in order to escape the pressures of lockdown, socially distance and avoid overcrowding. However, spatial cluster analyses also revealed that the places mapped by intensive users of natural recreational areas and more outdoor oriented users became more dispersed during the pandemic, suggesting their active search for new types of UGI, including use of agricultural land and residential areas with high tree density cover. Our results further highlighted that some types of UGI such as more distant natural and semi-natural areas and blue spaces serve as critical infrastructure both before and during the pandemic. Natural and semi-natural areas experienced very little change in use. The presented results have implications for how planners design and manage green spaces to enable residents to cope with crises like pandemics into the future.Peer reviewe