A framework for research on technology-enhanced special education

Based on results from the Technologies for Childrenwith Individual Needs Project and two case projects,we propose a new multidisciplinary framework forresearch between computer science, educationaltechnology, and special education. The frameworkpresents a way to conduct research that aims atdeveloping new methods for technology-enhancedspecial education and for developing adaptablesoftware and hardware tools for individual needs ineducational settings.Peer reviewe

Special education teachers’ views on their agency in teacher collaboration

Special education teachers’ (SETs) views on their agency in teacher collaboration were analysed using Cultural-Historical Activity Theory (CHAT). Finnish SETs (N = 238) answered open-ended survey questions concerning successful and unsuccessful collaboration with the classroom teachers in a tiered support framework. The findings revealed that the perceived agency of the special education teachers is both limited by and directed towards the classroom teachers’ understanding of the shared responsibility concerning support provision for students. Finally, the findings highlight the relevance of the cultural-historical activity theory by suggesting that the features of successful collaboration, in tandem with relevant constructs of the theory, constitute a mutual understanding of the goal of collaboration (shared object), structures (community) and guidance (norms) towards relevant use of instruments and fair division of responsibilities (division of labour). Implications for inclusive special education suggest that reciprocal reflection on the teaching practices requires shared everyday work between the SETs and the classroom teachers.</p

Thetis coastal ocean model: discontinuous Galerkin discretization for the three-dimensional hydrostatic equations

Unstructured grid ocean models are advantageous for simulating the coastal ocean and river–estuary–plume systems. However, unstructured grid models tend to be diffusive and/or computationally expensive, which limits their applicability to real-life problems. In this paper, we describe a novel discontinuous Galerkin (DG) finite element discretization for the hydrostatic equations. The formulation is fully conservative and second-order accurate in space and time. Monotonicity of the advection scheme is ensured by using a strong stability-preserving time integration method and slope limiters. Compared to previous DG models, advantages include a more accurate mode splitting method, revised viscosity formulation, and new second-order time integration scheme. We demonstrate that the model is capable of simulating baroclinic flows in the eddying regime with a suite of test cases. Numerical dissipation is well-controlled, being comparable or lower than in existing state-of-the-art structured grid models.</p

21. Environmental disclosure in Japanese wood-related companies for 2005 and 2010

Environmental and sustainability reports by private sectors are primarily aimed at information disclosure for individual entities. Comparison of such reports in two different years, provide us with unique opportunity to explore underpinning changes. This article compares Japanese wood-related sectors in 2005 and in 2010. During this half-decade, the economy was sluggish, with a number of dramatic meltdowns symbolized by the “Lehman shock” in 2008. The period also experience upheaval of environmental movements with a major UN COP on biodiversity taking place in Nagoya in 2010, making comparison of these two years more interesting. Environmental disclosure from 51 companies mainly from 7 wood related sectors was reviewed. The trends in disclosed information was reviewed based on the following criteria: publishing of environmental reports, reference to illegal logging, definition of sustainable forest management, and membership to the Global Compact. The results indicated an increase in many of the indicators for large size companies, particularly for trading companies, while the majority of small and mid-size companies did not conduct basic activities such as publishing reports.[Book Chapter]: 21. Environmental disclosure in Japanese wood-related companies for 2005 and 2010, Part V. Ecosystem Service and Socioeconomic Aspects with Special Reference to Biodiversity, Integrative Observations and Assessments (Ecological Research Monographs / Asia-Pacific Biodiversity Observation Network), edited by Shin-ichi Nakano(中野 伸一), Tetsukazu Yahara(矢原 徹一), Tohru Nakashizuka(浅野 透), DOI:10.1007/978-4-431-54783-

Distributed Model-to-Model Transformation with ATL on MapReduce

International audienceEfficient processing of very large models is a key requirement for the adoption of Model-Driven Engineering (MDE) in some industrial contexts. One of the central operations in MDE is rule-based model transformation (MT). It is used to specify manipulation operations over structured data coming in the form of model graphs. However, being based on com-putationally expensive operations like subgraph isomorphism, MT tools are facing issues on both memory occupancy and execution time while dealing with the increasing model size and complexity. One way to overcome these issues is to exploit the wide availability of distributed clusters in the Cloud for the distributed execution of MT. In this paper, we propose an approach to automatically distribute the execution of model transformations written in a popular MT language, ATL, on top of a well-known distributed programming model, MapReduce. We show how the execution semantics of ATL can be aligned with the MapReduce computation model. We describe the extensions to the ATL transformation engine to enable distribution, and we experimentally demonstrate the scalability of this solution in a reverse-engineering scenario

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.

Intercellular communication is fundamental to the survival and maintenance of all multicellular systems, whereas dysregulation of communication pathways can drive cancer progression. Extracellular vesicles (EVs) are mediators of cell-to-cell communication that regulate a variety of cellular processes involved in tumor progression. Overexpression of a specific plasma membrane enzyme, hyaluronan synthase 3 (HAS3), is one of the factors that can induce EV shedding. HAS3, and particularly its product hyaluronan (HA), are carried by EVs and are known to be associated with the tumorigenic properties of cancer cells. To elucidate the specific effects of cancerous, HAS3-induced EVs on target cells, normal human keratinocytes and melanoma cells were treated with EVs derived from GFP-HAS3 expressing metastatic melanoma cells. We found that the HA receptor CD44 participated in the regulation of EV binding to target cells. Furthermore, GFP-HAS3-positive EVs induced HA secretion, proliferation and invasion of target cells. Our results suggest that HAS3-EVs contains increased quantities of IHH, which activates the target cell hedgehog signaling cascade and leads to the activation of c-Myc and regulation of claspin expression. This signaling of IHH in HAS3-EVs resulted in increased cell proliferation. Claspin immunostaining correlated with HA content in human cutaneous melanocytic lesions, supporting our in vitro findings and suggesting a reciprocal regulation between claspin expression and HA synthesis. This study shows for the first time that EVs originating from HAS3 overexpressing cells carry mitogenic signals that induce proliferation and epithelial-to-mesenchymal transition in target cells. The study also identifies a novel feedback regulation between the hedgehog signaling pathway and HA metabolism in melanoma, mediated by EVs carrying HA and IHH.Peer reviewe

LIMPER trials : immediate mobilisation versus 2-week cast immobilisation after distal radius fracture treated with volar locking plate - a study protocol for a prospective, randomised, controlled trial

INTRODUCTION: Open reduction and internal fixation with volar locking plate has become the most common fixation method in the treatment of unstable distal radius fracture (DRF). There is, however, no consensus as to whether or for how long a wrist should be immobilised after operative treatment. To date, there have been relatively few studies that have evaluated the effect of immediate postoperative mobilisation on functional outcomes. The aim of postoperative rehabilitation is to obtain a good function and to reduce impairment, recovery time, socioeconomical costs and absence from work. Therefore, there is a need for studies that evaluate the optimal method of postoperative rehabilitation to optimise wrist function and return to work. METHODS AND ANALYSIS: This study is a prospective, randomised, controlled trial in which a total of 240 working-age patients who undergo volar plating for DRF will be randomly assigned to either an early mobilisation group or a postoperative 2-week casting group. The aim of the study will be to compare early postoperative outcomes between the study groups. The primary outcome will be patient-rated wrist evaluation at 2 months after operation. A coprimary outcome will be the total length of sick leave. Our follow-up period will be 1 year, and secondary outcomes will include pain, patient satisfaction, perceived ability to work and complications identified at different time points. We expect those patients who undergo immediate mobilisation will have at least as rapid a return to work and function as those patients who undergo postoperative immobilisation, indicating/meaning that there will be no need for postoperative casting. ETHICS AND DISSEMINATION: This study will be conducted according to the Standard Protocol Items: Recommendations for Interventional Trials statement. The Ethics committee of Tampere University Hospital has approved the protocol. Ethics committee approval number is R21111, and it is accepted on 7 September 2021. The results of this study will be submitted for publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT05150925.publishedVersionPeer reviewe

Особенности развития малого предпринимательства в Украине

В этой работе рассмотрена эволюция предпринимательства Украины на всех этапах ее общественной жизни, в том числе в период экономического кризиса в годы становления независимости. Отражены основные параметры отнесения предприятий к субъектам малого предпринимательства и их роль в развитии экономики государств.У цій роботі розглянута еволюція підприємництва України на всіх етапах її суспільного життя, зокрема в період економічної кризи в роки становлення незалежності. Відображені основні параметри віднесення підприємств до суб'єктів малого підприємництва і їх роль в розвитку економіки держав