Notes on the Verlinde formula in non-rational conformal field theories

We review and extend evidence for the validity of a generalized Verlinde formula in particular non-rational conformal field theories. We identify a subset of representations of the chiral algebra in non-rational conformal field theories that give rise to an analogue of the relation between modular S-matrices and fusion coefficients in rational conformal field theories. To that end we review and extend the Cardy-type brane calculations in bosonic and supersymmetric Liouville theory (and its duals) as well as in the hyperbolic three-plane H3+. We analyze the three-point functions of Liouville theory and of H3+ in detail to directly identify the fusion coefficients from the operator product expansion.Comment: 29 pages, 6 figures, v2: minor corrections, PRD versio

Muller C-element based Decoder (MCD): A Decoder Against Transient Faults

This work extends the analysis and application of a digital error correction method called Muller C-element Decoding (MCD), which has been proposed for fault masking in logic circuits comprised of unreliable elements. The proposed technique employs cascaded Muller C-elements and XOR gates to achieve efficient error-correction in the presence of internal upsets. The error-correction analysis of MCD architecture and the investigation of C-element’s robustness are first introduced. We demonstrate that the MCD is able to produce error-correction benefit in a high error-rate of internal faults. Significantly, for a (3,6) short-length LDPC code, when the decoding process is internally error-free the MCD achieves also a gain in terms of decoding performance by comparison to the well-known Gallager Bit-Flipping method. We further consider application of MCD to a general-purpose fault-tolerant model, coded Dual Modular Redundancy (cDMR), which offers low-redundancy error-resilience for contemporary logic systems as well as future nanoeletronic architectures

Simulating impacts of climate and management on timothy growth in Northern countries

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Plasmacytoid Precursor Dendritic Cells From NOD Mice Exhibit Impaired Function : Are They a Component of Diabetes Pathogenesis?

OBJECTIVE—Plasmacytoid precursor dendritic cell facilitating cells (p-preDC FCs) play a critical role in facilitation of syngeneic and allogeneic hematopoietic stem cell (HSC) engraftment. Here, we evaluated the phenotype and function of CD8+/TCR− FCs from NOD mice

Estimation des taux de recombinaison entre les locus Phi et Pgd et le complexe SLA chez le porc

International audienc

An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT(TM) is functionally superior to Freund's adjuvant

Passive immunotherapies utilising polyclonal antibodies could have a valuable role in preventing and treating infectious diseases such as influenza, particularly in pandemic situations but also in immunocompromised populations such as the elderly, the chronically immunosuppressed, pregnant women, infants and those with chronic diseases. The aim of this study was to optimise current methods used to generate ovine polyclonal antibodies. Polyclonal antibodies to baculovirus-expressed recombinant influenza haemagglutinin from A/Puerto Rico/8/1934 H1N1 (PR8) were elicited in sheep using various immunisation regimens designed to investigate the priming immunisation route, adjuvant formulation, sheep age, and antigen dose, and to empirically ascertain which combination maximised antibody output. The novel adjuvant CoVaccine HT™ was compared to Freund’s adjuvant which is currently the adjuvant of choice for commercial production of ovine polyclonal Fab therapies. CoVaccine HT™ induced significantly higher titres of functional ovine anti-haemagglutinin IgG than Freund’s adjuvant but with fewer side effects, including reduced site reactions. Polyclonal hyperimmune sheep sera effectively neutralised influenza virus in vitro and, when given before or after influenza virus challenge, prevented the death of infected mice. Neither the age of the sheep nor the route of antigen administration appeared to influence antibody titre. Moreover, reducing the administrated dose of haemagglutinin antigen minimally affected antibody titre. Together, these results suggest a cost effective way of producing high and sustained yields of functional ovine polyclonal antibodies specifically for the prevention and treatment of globally significant diseases.Natalie E. Stevens, Cara K. Fraser, Mohammed Alsharifi, Michael P. Brown, Kerrilyn R. Diener, John D. Haybal

To support and not to cure: general practitioner management of loneliness

Loneliness is associated with numerous detrimental effects on physical health, mental health, cognition and lifestyle. Older adults are one of the groups at highest risk of loneliness, and indeed about 46% of older adults in England feel lonely. Those experiencing loneliness visit their general practitioner (GP) more frequently than those who are not, which has the capacity to put a strain on GPs and primary care waiting lists and costs. This study's aim was to explore GPs' views and experiences of loneliness within their older adult patients, and to understand GPs' awareness and feelings of agency within this. Nineteen UK GPs were recruited using purposive sampling and snowballing techniques. Individual semi‐structured interviews were conducted either in person or over the telephone. Data were analysed using thematic analysis. Four overarching themes were identified from the data: Whose responsibility is it anyway?, Pandora's box of shame; Keeping distance; and Community responsibility. Themes emphasise that GPs tend to hold a medicalised and individualistic view of loneliness. This intensifies stigma which in turn creates barriers to raising the topic. GPs felt powerless in their ability to fix the ‘problem’ and tended to believe that the solution had to lie in the community, the individual or in social care rather than in primary care. The findings are discussed in the context of literature on GP management of other social problems which give rise to similar issues concerning the restrictions of the medical model and the need for joined‐up approaches in which the GP is one part of a wider social support structure. It is suggested that it might be useful for training and support for GPs to address management of social problems jointly rather than training specific to loneliness which GPs tend to see as peripheral to their core remit