Geology of Cumberland Gap National Historical Park

Cumberland Gap National Historical Park is located in parts of Kentucky, Virginia, and Tennessee. The park was authorized by President Franklin Roosevelt on June 11, 1940, and is now the largest historical park in the National Park System. It contains 24,000 acres along Cumberland Mountain near Ewing, Va., proceeding southwest toward Fern Lake in Tennessee, a distance of approximately 20 miles. The average width of the park is only 1.6 miles. The park hosts a distinctive range of geologic processes and features. Unique structural geology, caves and karst, surface and groundwater erosion, and mass wasting are just a few of the processes that shape the scenic landscape of the park. This publication illustrates the relationship between the geology of Cumberland Gap and the historical and cultural issues that are important to the park and its visitors. It is intended for park visitors, educators, park staff, and anyone interested in the geology of Cumberland Gap National Historical Park. It was produced using digital geologic mapping and geographic information system technology, which also help the National Park Service with resource management and meeting federal mandates, while also providing informative perspectives that are valuable to all citizens who enjoy national parks. For more information, please visit the Cumberland Gap National Historical Park Web site at www.nps.gov/cuga. To obtain digital geologic and other GIS data, visit the National Park Service Data Portal at nrinfo.nps.govtReference.mvc/Search

Towards a Lightweight Approach for Modding Serious Educational Games: Assisting Novice Designers

Serious educational games (SEGs) are a growing segment of the education community’s pedagogical toolbox. Effectively creating such games remains challenging, as teachers and industry trainers are content experts; typically they are not game designers with the theoretical knowledge and practical experience needed to create a quality SEG. Here, a lightweight approach to interactively explore and modify existing SEGs is introduced, a toll that can be broadly adopted by educators for pedagogically sound SEGs. Novice game designers can rapidly explore the educational and traditional elements of a game, with a stress on tracking the SEG learning objectives, as well as allowing for reviewing and altering a variety of graphic and audio game elements

Hubble Space Telescope Images of Stephan's Quintet: Star Cluster Formation in a Compact Group Environment

Analysis of Hubble Space Telescope/Wide Field Planetary Camera 2 images of Stephan's Quintet, Hickson Compact Group 92, yielded 115 candidate star clusters (with V-I < 1.5). Unlike in merger remants, the cluster candidates in Stephan's Quintet are not clustered in the inner regions of the galaxies; they are spread over the debris and surrounding area. Specifically, these sources are located in the long sweeping tail and spiral arms of NGC 7319, in the tidal debris of NGC 7318B/A, and in the intragroup starburst region north of these galaxies. Analysis of the colors of the clusters indicates several distinct epochs of star formation that appear to trace the complex history of dynamical interactions in this compact group.Comment: 24 pages, 21 figures (13 PostScript and 8 JPEG), LaTeX (uses aastexug.sty), accepted for publication in the Astronomical Journal (July 2001). Full-resolution PostScript figures available at http://www.astro.psu.edu/users/gallsc/sq/figs.tar.g

Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake.

Background/Objectives:The Child And Diet Evaluation Tool (CADET) is a 24-h food diary that measures the nutrition intake of children aged 3-7 years, with a focus on fruit and vegetable consumption. Until now CADET has not been used to measure nutrient intake of children aged 8-11 years. To ensure that newly assigned portion sizes for this older age group were valid, participants were asked to complete the CADET diary (the school and home food diary) concurrently with a 1-day weighed record. Subjects/Methods:A total of 67 children with a mean age of 9.3 years (s.d.: ± 1.4, 51% girls) participated in the study. Total fruit and vegetable intake in grams and other nutrients were extracted to compare the mean intakes from the CADET diary and Weighed record using t-tests and Pearson's r correlations. Bland-Altman analysis was also conducted to assess the agreement between the two methods. Results: Correlations comparing the CADET diary to the weighed record were high for fruit, vegetables and combined fruit and vegetables (r=0.7). The results from the Bland-Altman plots revealed a mean difference of 54 g (95% confidence interval: -88, 152) for combined fruit and vegetables intake. CADET is the only tool recommended by the National Obesity Observatory that has been validated in a UK population and provides nutrient level data on children's diets. Conclusions:The results from this study conclude that CADET can provide high-quality nutrient data suitable for evaluating intervention studies now for children aged 3-11 years with a focus on fruit and vegetable intake

Prompt optical observations of GRB050319 with the Swift UVOT

The UVOT telescope on the Swift observatory has detected optical afterglow emission from GRB 050319. The flux declines with a power law slope of alpha = -0.57 between the start of observations some 230 seconds after the burst onset (90s after the burst trigger) until it faded below the sensitivity threshold of the instrument after ~5 x 10^4s. There is no evidence for the rapidly declining component in the early light curve that is seen at the same time in the X-ray band. The afterglow is not detected in UVOT shortward of the B-band, suggesting a redshift of about 3.5. The optical V-band emission lies on the extension of the X-ray spectrum, with an optical to X-ray slope of beta = -0.8. The relatively flat decay rate of the burst suggests that the central engine continues to inject energy into the fireball for as long as a few x 10^4s after the burst.Comment: 16 pages, 4 figures, accepted by Ap

Swift-UVOT detection of GRB 050318

We present observations of GRB 050318 by the Ultra-Violet and Optical Telescope (UVOT) on-board the Swift observatory. The data are the first detections of a Gamma Ray Burst (GRB) afterglow decay by the UVOT instrument, launched specifically to open a new window on these transient sources. We showcase UVOTs ability to provide multi-color photometry and the advantages of combining UVOT data with simultaneous and contemporaneous observations from the high-energy detectors on the Swift spacecraft. Multiple filters covering 1,800-6,000 Angstroms reveal a red source with spectral slope steeper than the simultaneous X-ray continuum. Spectral fits indicate that the UVOT colors are consistent with dust extinction by systems at z = 1.2037 and z = 1.4436, redshifts where absorption systems have been pre-identified. However, the data can be most-easily reproduced with models containing a foreground system of neutral gas redshifted by z = 2.8 +/- 0.3. For both of the above scenarios, spectral and decay slopes are, for the most part, consistent with fireball expansion into a uniform medium, provided a cooling break occurs between the energy ranges of the UVOT and Swifts X-ray instrumentation.Comment: 15 pages, 4 figures, ApJ Letters, in pres

From Globular Clusters to Tidal Dwarfs: Structure Formation in the Tidal Tails of Merging Galaxies

Using V and I images obtained with WFPC2/HST, we investigate compact stellar structures within tidal tails. Six regions of tidal debris in the four classic ``Toomre Sequence'' mergers: NGC 4038/39 (``Antennae''), NGC 3256, NGC 3921, and NGC 7252 (``Atoms for Peace'') have been studied in order to explore how the star formation depends upon the local and global physical conditions. These mergers sample a range of stages in the evolutionary sequence and tails with and without embedded tidal dwarf galaxies. The six tails are found to contain a variety of stellar structures, with sizes ranging from those of globular clusters up to those of dwarf galaxies. From V and I WFPC2 images, we measure the luminosities and colors of the star clusters. NGC 3256 is found to have a large population of blue clusters (0.2 < V-I < 0.9), particularly in its Western tail, similar to those found in the inner region of the merger. In contrast, NGC 4038/39 has no clusters in the observed region of the tail, only less luminous point sources likely to be individual stars. A significant cluster population is clearly associated with the prominent tidal dwarf candidates in the eastern and western tails of NGC 7252. The cluster-rich Western tail of NGC 3256 is not distinguished from the others by its dynamical age or by its total HI mass. However, the mergers that have few clusters in the tail all have tidal dwarf galaxies, while NGC 3256 does not have prominent tidal dwarfs. We speculate that star formation in tidal tails may manifest itself either in small structures like clusters along the tail or in large structures such as dwarf galaxies, but not in both. Also, NGC 3256 has the highest star formation rate of the four mergers studied, which may contribute to the high number of star clusters in its tidal tails.Comment: Accepted to Astronomical Journal. 34 pages including 15 figures and 4 table

Identifying Old Tidal Dwarf Irregulars

We examine the observational consequences of the two possible origins for irregular galaxies: formation from collapse of a primordial cloud of gas early in the age of the Universe, and formation from tidal tails in an interaction that could have occured any time in the history of the Universe. Because the formation from tidal tails could have occurred a long time ago, proximity to larger galaxies is not sufficient to distinguish tidal dwarfs from traditional dwarfs. We consider the effects of little or no dark matter on rotation speeds and the Tully-Fisher relationship, the metallicity-luminosity relationship, structure, and stellar populations. From these selection criteria, we identify a small list of dwarf irregular galaxies that are candidates for having formed as tidal dwarfs.Comment: ApJ, to appear September 20, 200

Acute effects of insulin and insulin-induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs

Funding: Silvia V. Conde declares that Galvani Bioelectronics provided funds to support their work associated with Type 2 diabetic project.New Findings: What is the central question of this study? What are the effects of insulin and insulin-induced hypoglycaemia on carotid body chemoreceptor activity in vivo and how do carotid body chemoreceptor stimulation-mediated cardiorespiratory responses in beagle dogs compare during euglycaemia and insulin-induced hypoglycaemia? What is the main finding and its importance? Intracarotid insulin administration leads to sustained increase in carotid body chemoreceptor activity and respiratory response with significant cardiovascular effects. Insulin-induced hypoglycaemia exacerbated NaCN-mediated carotid body chemoreceptor activity and respiratory response with enhanced cardiovascular reflex response. These findings suggest that insulin-induced hypoglycaemia augments the carotid body chemoreceptors to initiate the adaptive counter-regulatory responses to restore the normoglycaemic condition. Abstract: The carotid body chemoreceptors (CBC) play an important role in the adaptive counter-regulatory response to hypoglycaemia by evoking the CBC-mediated sympathetic neuronal system to restore normoglycaemia. Ex vivo studies have shown varied responses of insulin-induced hypoglycaemia on CBC function, and several in vivo studies have indirectly established the role of CBCs in restoring normoglycaemia in both animals and humans. However, a direct effect of insulin and/or insulin-induced hypoglycaemia on CBC activity is not established in animal models. Therefore, the aim of this study was to evaluate in vivo effects of insulin and insulin-induced hypoglycaemia on CBC activity and cardiorespiration in a preclinical large animal model. The carotid sinus nerve (CSN) activity and cardiorespiratory responses to sodium cyanide (NaCN; 25 µg/kg) were compared before (euglycaemic) and after (hypoglycaemic) intracarotid administration of insulin (12.5–100 µU/dogs) in beagle dogs. Insulin administration increased CSN activity and minute ventilation ((Formula presented.) E) with significant (P < 0.0001) effects on heart rate and blood pressure. Insulin-mediated effects on CSN and cardiorespiration were sustained and the change in (Formula presented.) E was driven by tidal volume only. Insulin significantly (P < 0.0001) lowered blood glucose level. NaCN-mediated CSN activity and (Formula presented.) E were significantly (P < 0.0001) augmented during insulin-induced hypoglycaemia. The augmented (Formula presented.) E was primarily driven by respiratory frequency and partially by tidal volume. The cardiovascular reflex response mediated through CBC stimulation was significantly (P < 0.0001) exacerbated during insulin-induced hypoglycaemia. Collectively, these results demonstrate direct effects of insulin and insulin-induced hypoglycaemia on CBC chemosensitivity to potentiate CBC-mediated neuroregulatory pathways to initiate adaptive neuroendocrine and cardiorespiratory counter-regulatory responses to restore normoglycaemia.publishersversionepub_ahead_of_prin

Human Adipose Stromal Cells Increase Survival and Mesenteric Perfusion Following Intestinal Ischemia and Reperfusion Injury

OBJECTIVE: Intestinal ischemia can quickly escalate to bowel necrosis and perforation. Transplantation of stem cells presents a novel treatment modality for this problem. We hypothesized that: human adipose-derived stromal cells (hASCs) would increase survival and mesenteric perfusion to a greater degree compared with differentiated cellular controls following ischemic intestinal injury, and improved outcomes with hASC therapy would be associated with preservation of intestinal histological and tight junction architecture, and lower levels of systemic inflammation following intestinal injury. METHODS: hASCs and keratinocytes (differentiated cellular control) were cultured on polystyrene flasks at 37°C in 5% CO2 in air. Adult male C57Bl6J mice were anesthetized and a midline laparotomy performed. The intestines were eviscerated, the small bowel mesenteric root identified, and intestinal ischemia was established by temporarily occluding the superior mesenteric artery for 60 min with a noncrushing vascular clamp. Following ischemia, the clamp was removed, and the intestines were returned to the abdominal cavity. Before abdominal closure, 2 million hASCs or keratinocytes in 250 μL of phosphate-buffered saline (carrier for cells and control solution) were infused into the peritoneum. Animals were allowed to recover for 12 or 24 h (perfusion, histology, cytokine, and immunofluoresence studies), or 7 days (survival studies). Intestinal perfusion was assessed by laser Doppler imaging. Intestinal tissue segments were stained with hematoxylin and eosin, as well as antibodies for the tight junction protein claudin-1. Separate aliquots of intestine, liver, and lung tissue were homogenized and assessed for inflammatory cytokines via multiplex beaded assay. RESULTS: Animals administered hASCs following intestinal ischemia and reperfusion (I/R) injury had significantly greater 7-day survival and better postischemic recovery of mesenteric perfusion compared with vehicle or keratinocyte therapy. hASCs also abated intestinal mucosal destruction, facilitated preservation of intestinal tight junctions, and decreased the systemic inflammatory response to injury. CONCLUSIONS: Human adipose-derived stromal cells improved survival and mesenteric perfusion and attenuated the mucosal damage associated with intestinal I/R injury. hASCs should be considered as a plausible cell source for novel cellular treatment plans following intestinal ischemia