Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea.

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages

Small neutrino masses and gauge coupling unification

The physics responsible for gauge coupling unification may also induce small neutrino masses. We propose a novel gauge-mediated radiative seesaw mechanism for calculable neutrino masses. These arise from quantum corrections mediated by new SU(3)(C) circle times SU(3)(L) circle times U(1)(X) (3-3-1) gauge bosons and the physics driving gauge coupling unification. Gauge couplings unify for a 3-3-1 scale in the TeV range, making the model directly testable at the LHC

Analysis and visualization of the dynamics of research groups in terms of projects and co-authored publications : A case study of library and information science in Argentina

Objective: The present study offers a novel methodological contribution to the study of the configuration and dynamics of research groups, through a comparative perspective of the projects funded (inputs) and publication co-authorships (output). Method: A combination of bibliometric techniques and social network analysis was applied to a case study: the Departmento de Bibliotecología (DHUBI), Universidad Nacional de La Plata, Argentina, for the period 2000-2009. The results were interpreted statistically and staff members of the department, were interviewed. Results: The method makes it possible to distinguish groups, identify their members and reflect group make-up through an analytical strategy that involves the categorization of actors and the interdisciplinary and national or international projection of the networks that they configure. The integration of these two aspects (input and output) at different points in time over the analyzed period leads to inferences about group profiles and the roles of actors. Conclusions: The methodology presented is conducive to micro-level interpretations in a given area of study, regarding individual researchers or research groups. Because the comparative input-output analysis broadens the base of information and makes it possible to follow up, over time, individual and group trends, it may prove very useful for the management, promotion and evaluation of scienceFacultad de Humanidades y Ciencias de la Educació

Analysis and visualization of the dynamics of research groups in terms of projects and co-authored publications : A case study of library and information science in Argentina

Objective: The present study offers a novel methodological contribution to the study of the configuration and dynamics of research groups, through a comparative perspective of the projects funded (inputs) and publication co-authorships (output). Method: A combination of bibliometric techniques and social network analysis was applied to a case study: the Departmento de Bibliotecología (DHUBI), Universidad Nacional de La Plata, Argentina, for the period 2000-2009. The results were interpreted statistically and staff members of the department, were interviewed. Results: The method makes it possible to distinguish groups, identify their members and reflect group make-up through an analytical strategy that involves the categorization of actors and the interdisciplinary and national or international projection of the networks that they configure. The integration of these two aspects (input and output) at different points in time over the analyzed period leads to inferences about group profiles and the roles of actors. Conclusions: The methodology presented is conducive to micro-level interpretations in a given area of study, regarding individual researchers or research groups. Because the comparative input-output analysis broadens the base of information and makes it possible to follow up, over time, individual and group trends, it may prove very useful for the management, promotion and evaluation of scienceFacultad de Humanidades y Ciencias de la Educació

Reading-related Cognitive Deficits in Spanish Developmental Dyslexia

AbstractSpanish-speaking children learn to read words written in a relatively transparent orthography. Variations in orthographic transparency may shape the manifestation of reading difficulties. This study was intended to help clarify the nature of developmental dyslexia in Spanish. Developmentally Dyslexic children (DD) were compared to a chronological age-matched control group (CA). Measures included rapid automated naming, verbal working memory, phonological short-term memory, and phonemic awareness. Results demonstrated that developmental dyslexics show reading-related cognitive deficits in areas such as naming speed, verbal working memory, phonological short-term memory, and phonemic awareness. Our results are consistent with studies conducted in the Spanish language and in other transparent orthographies

Neurodiseño y neurousabilidad de automóviles. Una propuesta desde la ingeniería neurokansei-chisei

En este trabajo de investigación se plantea una innovación metodológica en los procesos de diseño y desarrollo de productos industriales, con enfoque en el usuario. El objetivo central es el planteamiento de un modelo de orientación neurocientífica para la aplicación de la Ingeniería Kansei-Chisei al diseño de productos en el sector del automóvil. Esta propuesta participa en la ampliación del concepto de ergonomía aplicada a productos y a entornos de trabajo, la cual ha evolucionado desde los conceptos de ergonomía clásica o ergonomía física hacia otros ámbitos relacionados con la incorporación e interacción emocional y racional del diseño. En el ámbito de la ergonomía, el diseño productos ha evolucionado de una concepción racional centrada exclusivamente en la eficiencia práctica, a planteamientos de concepción emocional mediante la incorporación de soluciones de diseño afectivo por Ingeniería Kansei. El objetivo final de la Ingeniería Kansei Chisei es establecer la relación entre emoción, razón y propiedades vehículo, de tal manera que los resultados puedan ser utilizados para mejorar el confort y la eficiencia del producto.In this research work, is proposed a methodological innovation in the design and development processes of industrial products, with a focus on the user. The central aim is the approach of a neuroscientific orientation model for the application of Kansei-Chisei Engineering to the design of products in the automotive sector. This proposal participates in the expansion of the concept of ergonomics applied to products and work environments, which has evolved from the concepts of classical ergonomics or physical ergonomics to other areas related to the incorporation and emotional and rational interaction of design. In the field of ergonomics, product design has evolved from a rational conception focused exclusively on practical efficiency, to approaches of emotional conception through the incorporation of affective design solutions by Kansei Engineering. The final objective of the Kansei-Chisei Engineering is to establish the relationship between emotion, reason and vehicle properties, in such a way that the results can be used to improve the comfort and efficiency of the product.Plan Propio de la Universidad de Sevilla Proyecto: 2017/0000096

Optimización de sistemas de prevención de riesgos laborales en entornos de trabajo conectados e inteligentes. Aplicación a la construcción 4.0

Los programas de Horizonte 2020 y el conjunto de líneas de investigación propuestas internacionalmente relacionadas con la Cuarta Revolución Industrial o Industria 4.0, reflejan el interés y necesidad de ampliar el alcance de la gestión de los riesgos ocupacionales en los sistemas productivos desde el punto de vista de la digitalización y automatización para asegurar la protección integral del trabajador. Partiendo de esta situación, y teniendo en cuenta el auge que en los últimos años está teniendo la Industria 4.0 a través del inicio de la Cuarta Revolución Industrial en todos los sectores de actividad, habría que plantearse (1) cuáles son los facilitadores tecnológicos y digitales más idóneos para alcanzar la automatización y digitalización fomentada para el alcance de los sistemas de construcción inteligentes (Construcción 4.0), (2) cómo conseguir una integración eficiente entre tecnología y trabajador (productos inteligentes, wearables) y (3) la forma de configurar dicha integración, como solución al rápido aumento de la incorporación de nuevas tecnologías, sistemas TIC y digitalización. En este contexto se desarrolla el presente artículo: teniendo en cuenta que el diseño actual de los dispositivos inteligentes aún no está adaptado a entornos ocupacionales y considerando los nuevos retos para la construcción 4.0.The Horizon 2020 programs and the set of internationally proposed research lines related to the Fourth Industrial Revolution or Industry 4.0 reflect the interest and need to broaden the scope of the management of occupational risks in the production systems from the point of view of digitization and automation to ensure the full protection of the worker. Starting from this situation, and taking into account the boom that Industry 4.0 is having in recent years through the start of the Fourth Industrial Revolution in all sectors of activity, we should consider (1) what the technological and digital facilitators are best suited to achieve the automation and digitalization promoted for the scope of intelligent construction systems (Construction 4.0), (2) how to achieve an efficient integration between technology and worker (intelligent products, wearables) and (3) how to configure such integration, as a solution to the rapid increase in the incorporation of new technologies, ICT systems and digitalisation. In this context the present article is developed: bearing in mind that the current design of intelligent devices is not yet adapted to occupational environments and considering the new challenges for construction 4.0