Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea.

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages

Small neutrino masses and gauge coupling unification

The physics responsible for gauge coupling unification may also induce small neutrino masses. We propose a novel gauge-mediated radiative seesaw mechanism for calculable neutrino masses. These arise from quantum corrections mediated by new SU(3)(C) circle times SU(3)(L) circle times U(1)(X) (3-3-1) gauge bosons and the physics driving gauge coupling unification. Gauge couplings unify for a 3-3-1 scale in the TeV range, making the model directly testable at the LHC

Analysis and visualization of the dynamics of research groups in terms of projects and co-authored publications : A case study of library and information science in Argentina

Objective: The present study offers a novel methodological contribution to the study of the configuration and dynamics of research groups, through a comparative perspective of the projects funded (inputs) and publication co-authorships (output). Method: A combination of bibliometric techniques and social network analysis was applied to a case study: the Departmento de Bibliotecología (DHUBI), Universidad Nacional de La Plata, Argentina, for the period 2000-2009. The results were interpreted statistically and staff members of the department, were interviewed. Results: The method makes it possible to distinguish groups, identify their members and reflect group make-up through an analytical strategy that involves the categorization of actors and the interdisciplinary and national or international projection of the networks that they configure. The integration of these two aspects (input and output) at different points in time over the analyzed period leads to inferences about group profiles and the roles of actors. Conclusions: The methodology presented is conducive to micro-level interpretations in a given area of study, regarding individual researchers or research groups. Because the comparative input-output analysis broadens the base of information and makes it possible to follow up, over time, individual and group trends, it may prove very useful for the management, promotion and evaluation of scienceFacultad de Humanidades y Ciencias de la Educació

Analysis and visualization of the dynamics of research groups in terms of projects and co-authored publications : A case study of library and information science in Argentina

Objective: The present study offers a novel methodological contribution to the study of the configuration and dynamics of research groups, through a comparative perspective of the projects funded (inputs) and publication co-authorships (output). Method: A combination of bibliometric techniques and social network analysis was applied to a case study: the Departmento de Bibliotecología (DHUBI), Universidad Nacional de La Plata, Argentina, for the period 2000-2009. The results were interpreted statistically and staff members of the department, were interviewed. Results: The method makes it possible to distinguish groups, identify their members and reflect group make-up through an analytical strategy that involves the categorization of actors and the interdisciplinary and national or international projection of the networks that they configure. The integration of these two aspects (input and output) at different points in time over the analyzed period leads to inferences about group profiles and the roles of actors. Conclusions: The methodology presented is conducive to micro-level interpretations in a given area of study, regarding individual researchers or research groups. Because the comparative input-output analysis broadens the base of information and makes it possible to follow up, over time, individual and group trends, it may prove very useful for the management, promotion and evaluation of scienceFacultad de Humanidades y Ciencias de la Educació

Optimización de sistemas de prevención de riesgos laborales en entornos de trabajo conectados e inteligentes. Aplicación a la construcción 4.0

Los programas de Horizonte 2020 y el conjunto de líneas de investigación propuestas internacionalmente relacionadas con la Cuarta Revolución Industrial o Industria 4.0, reflejan el interés y necesidad de ampliar el alcance de la gestión de los riesgos ocupacionales en los sistemas productivos desde el punto de vista de la digitalización y automatización para asegurar la protección integral del trabajador. Partiendo de esta situación, y teniendo en cuenta el auge que en los últimos años está teniendo la Industria 4.0 a través del inicio de la Cuarta Revolución Industrial en todos los sectores de actividad, habría que plantearse (1) cuáles son los facilitadores tecnológicos y digitales más idóneos para alcanzar la automatización y digitalización fomentada para el alcance de los sistemas de construcción inteligentes (Construcción 4.0), (2) cómo conseguir una integración eficiente entre tecnología y trabajador (productos inteligentes, wearables) y (3) la forma de configurar dicha integración, como solución al rápido aumento de la incorporación de nuevas tecnologías, sistemas TIC y digitalización. En este contexto se desarrolla el presente artículo: teniendo en cuenta que el diseño actual de los dispositivos inteligentes aún no está adaptado a entornos ocupacionales y considerando los nuevos retos para la construcción 4.0.The Horizon 2020 programs and the set of internationally proposed research lines related to the Fourth Industrial Revolution or Industry 4.0 reflect the interest and need to broaden the scope of the management of occupational risks in the production systems from the point of view of digitization and automation to ensure the full protection of the worker. Starting from this situation, and taking into account the boom that Industry 4.0 is having in recent years through the start of the Fourth Industrial Revolution in all sectors of activity, we should consider (1) what the technological and digital facilitators are best suited to achieve the automation and digitalization promoted for the scope of intelligent construction systems (Construction 4.0), (2) how to achieve an efficient integration between technology and worker (intelligent products, wearables) and (3) how to configure such integration, as a solution to the rapid increase in the incorporation of new technologies, ICT systems and digitalisation. In this context the present article is developed: bearing in mind that the current design of intelligent devices is not yet adapted to occupational environments and considering the new challenges for construction 4.0

Propuesta de fabricación fractal distribuida para la optimización de la sostenibilidad de la industria aeronáutica en industria 4.0

Los programas de Horizonte 2020 y el conjunto de investigaciones propuestas a nivel internacional relacionadas con la Cuarta Revolución Industrial y la Industria 4.0 reflejan el interés y la necesidad de ampliar el alcance del diseño, simulación, optimización, así como la ejecución y gestión de los sectores de fabricación en los sistemas productivos, desde el punto de vista de la digitalización y automatización, para el alcance de los objetivos de la sostenibilidad: (1) el control y prevención de la contaminación; (2) la reducción del impacto y del daño ambiental y social; y (3) el aseguramiento de la viabilidad técnica, económica y de calidad de los resultados. La propuesta de nuevas formas organizativas (entre ellas la organización fractal), así como nuevos entornos de fabricación digitalizados con nuevas tecnologías conectadas (facilitadores digitales y tecnológicos), son una oportunidad para las actividades de I+D+i en el área de conocimiento de la fabricación en todos los sectores industriales, entre ellos, el de la industria aeronáutica.The programs Horizon 2020 and the set of internationally proposed research areas regarding the Fourth Industrial Revolution and Industry 4.0 reflect the interest and need to extend the scope of design, simulation, optimization, as well as the execution and management of manufacturing sectors in production systems from the point of view of digitalization and automation to achieve the objectives of sustainability: (1) controlling and preventing pollution; (2) reducing the impact as well as environmental and social damage; and (3) assuring technical, economic and quality viability of the results. The proposal of new organizational forms (including fractal organization), as well as new digitalized manufacturing environments with new connected technologies (digital and technological facilitators) are opportunities for R+D+I activities in the knowledge area of manufacturing in all industrial sectors, including the aeronautical industry.Plan Propio de la Universidad de Sevilla Proyecto: 2017/0000096