Revised structural phase diagram of (Ba0.7Ca0.3TiO3)-(BaZr0.2Ti0.8O3)

The temperature-composition phase diagram of barium calcium titanate zirconate (x(Ba0.7Ca0.3TiO3)(1-x)(BaZr0.2Ti0.8O3); BCTZ) has been reinvestigated using high-resolution synchrotron x-ray powder diffraction. Contrary to previous reports of an unusual rhombohedral-tetragonal phase transition in this system, we have observed an intermediate orthorhombic phase, isostructural to that present in the parent phase, BaTiO3, and we identify the previously assigned T-R transition as a T-O transition. We also observe the O-R transition coalescing with the previously observed triple point, forming a phase convergence region. The implication of the orthorhombic phase in reconciling the exceptional piezoelectric properties with the surrounding phase diagram is discussed

Higher order approximation of isochrons

Phase reduction is a commonly used techinque for analyzing stable oscillators, particularly in studies concerning synchronization and phase lock of a network of oscillators. In a widely used numerical approach for obtaining phase reduction of a single oscillator, one needs to obtain the gradient of the phase function, which essentially provides a linear approximation of isochrons. In this paper, we extend the method for obtaining partial derivatives of the phase function to arbitrary order, providing higher order approximations of isochrons. In particular, our method in order 2 can be applied to the study of dynamics of a stable oscillator subjected to stochastic perturbations, a topic that will be discussed in a future paper. We use the Stuart-Landau oscillator to illustrate the method in order 2

Immune Response to Cytolethal Distending Toxin of Aggregatibacter Actinomycetemcomitans in Periodontitis Patients

Background and Objective Cytolethal distending toxin (CDT) is a genotoxin produced by Aggregatibacter actinomycetemcomitans. In spite of its association with pathogenesis, little is known about the humoral immune response against the CDT. This study aimed to test whether subgingival colonization and humoral response to A. actinomycetemcomitans would lead to a response against CDT. Material and Methods Sera from periodontally healthy, localized and generalized aggressive periodontitis and chronic periodontitis subjects (n = 80) were assessed for immunoglobulin G titers to A. actinomycetemcomitans serotypes a/b/c and to each CDT subunit (CdtA, CdtB and CdtC) by ELISA. A. actinomycetemcomitans subgingival levels and neutralization of CDT activity were also analyzed. Results Sera from 75.0% localized and 81.8% generalized aggressive periodontitis patients reacted to A. actinomycetemcomitans. A response to serotype b was detected in localized (66.7%) and generalized aggressive periodontitis (54.5%). Reactivity to A. actinomycetemcomitans correlated with subgingival colonization (R = 0.75, p \u3c 0.05). There was no correlation between A. actinomycetemcomitans colonization or response to serotypes and the immunoglobulin G response to CDT subunits. Titers of immunoglobulin G to CdtA and CdtB did not differ among groups; however, sera of all generalized aggressive periodontitis patients reacted to CdtC. Neutralization of CDT was not correlated with levels of antibodies to CDT subunits. Conclusion Response to CdtA and CdtB did not correlate with the periodontal status of the subject in the context of an A. actinomycetemcomitans infection. However, a response to CdtC was found in sera of generalized but not of localized aggressive periodontitis subjects. Differences in response to CdtC between generalized and localized aggressive periodontitis subjects indicate that CDT could be expressed differently by the infecting strains. Alternatively, the antibody response to CdtC could require the colonization of multiple sites

The Modular Group Action on Real SL(2)-characters of a One-Holed Torus

The group Gamma of automorphisms of the polynomial kappa(x,y,z) = x^2 + y^2 + z^2 - xyz -2 is isomorphic to PGL(2,Z) semi-direct product with (Z/2+Z/2). For t in R, Gamma-action on ktR = kappa^{-1}(t) intersect R displays rich and varied dynamics. The action of Gamma preserves a Poisson structure defining a Gamma-invariant area form on each ktR. For t < 2, the action of Gamma is properly discontinuous on the four contractible components of ktR and ergodic on the compact component (which is empty if t < -2). The contractible components correspond to Teichmueller spaces of (possibly singular) hyperbolic structures on a torus M-bar. For t = 2, the level set ktR consists of characters of reducible representations and comprises two ergodic components corresponding to actions of GL(2,Z) on (R/Z)^2 and R^2 respectively. For 2 < t <= 18, the action of Gamma on ktR is ergodic. Corresponding to the Fricke space of a three-holed sphere is a Gamma-invariant open subset Omega subset R^3 whose components are permuted freely by a subgroup of index 6 in Gamma. The level set ktR intersects Omega if and only if t > 18, in which case the Gamma-action on the complement ktR - Omega is ergodic.Comment: Published by Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol7/paper13.abs.html Note: Version 4 takes account of the referee's comments (version 3 was published in error

Billiards in a general domain with random reflections

We study stochastic billiards on general tables: a particle moves according to its constant velocity inside some domain ${\mathcal D} \subset {\mathbb R}^d$ until it hits the boundary and bounces randomly inside according to some reflection law. We assume that the boundary of the domain is locally Lipschitz and almost everywhere continuously differentiable. The angle of the outgoing velocity with the inner normal vector has a specified, absolutely continuous density. We construct the discrete time and the continuous time processes recording the sequence of hitting points on the boundary and the pair location/velocity. We mainly focus on the case of bounded domains. Then, we prove exponential ergodicity of these two Markov processes, we study their invariant distribution and their normal (Gaussian) fluctuations. Of particular interest is the case of the cosine reflection law: the stationary distributions for the two processes are uniform in this case, the discrete time chain is reversible though the continuous time process is quasi-reversible. Also in this case, we give a natural construction of a chord "picked at random" in ${\mathcal D}$, and we study the angle of intersection of the process with a $(d-1)$-dimensional manifold contained in ${\mathcal D}$.Comment: 50 pages, 10 figures; To appear in: Archive for Rational Mechanics and Analysis; corrected Theorem 2.8 (induced chords in nonconvex subdomains

Relationships Between Subgingival Microbiota and GCF Biomarkers in Generalized Aggressive Periodontitis

Aim To examine relationships between subgingival biofilm composition and levels of gingival crevicular fluid (GCF) cytokines in periodontal health and generalized aggressive periodontitis (GAP). Materials and methods Periodontal parameters were measured in 25 periodontally healthy and 31 GAP subjects. Subgingival plaque and GCF samples were obtained from 14 sites from each subject. 40 subgingival taxa were quantified using checkerboard DNA-DNA hybridization and the concentrations of 8 GCF cytokines measured using Luminex. Cluster analysis was used to define sites with similar subgingival microbiotas in each clinical group. Significance of differences in clinical, microbiological and immunological parameters among clusters was determined using the Kruskal-Wallis test. Results GAP subjects had statistically significantly higher GCF levels of interleukin-1β (IL-1β) (p\u3c0.001), granulocyte-macrophage colony-stimulating factor (GM-CSF) (p\u3c0.01), and IL-1β/IL-10 ratio (p\u3c0.001) and higher proportions of Red and Orange complex species than periodontally healthy subjects. There were no statistically significant differences in the mean proportion of cytokines among clusters in the periodontally healthy subjects, while the ratio IL-1β/IL-10 (p\u3c0.05) differed significantly among clusters in the aggressive periodontitis group. Conclusions Different subgingival biofilm profiles are associated with distinct patterns of GCF cytokine expression. Aggressive periodontitis subjects were characterized by a higher IL-1β/IL-10 ratio than periodontally healthy subjects, suggesting an imbalance between pro- and anti-inflammatory cytokines in aggressive periodontitis

Pregnancy losses after transfer of bovine embryos produced by assisted reproductive technologies.

Edição dos resumos da Annual Conference of the International Embryo Technology Society, New Orleans, Louisiana, 2019

Role of endothelial kinin B(1) receptor on the membrane potential of transgenic rat aorta

The kinin receptors are classically involved in inflammation, pain and sepsis. The effects of the kinin B(1) receptor agonist des-Arg(9)-bradykinin (DBK) and lipopolysaccharide (LPS) were investigated by comparing the membrane potential responses of aortic rings from transgenic rats overexpressing the kinin B1 receptor (B1R) in the endothelium (TGR(Tie2B1)) and Sprague Dawley (SD) rats. No difference in the resting membrane potential in the aorta's smooth muscle from the transgenic and SD rats was observed. The aorta rings from SD rats hyperpolarized only to LPS but not to DBK, whereas the aorta rings from TGR(Tie2B(1)) responded by the administration of both drugs. DBK and LPS responses were inhibited by the B(1) receptor antagonist R715 and by iberiotoxin in both cases. Thapsigargin induced a hyperpolarization in the smooth muscle of SD rats that was not reversed by R715, but was reversed by iberiotoxin and this hyperpolarization was further augmented by DBK administration. These results show that the model of overexpression of vascular B(1) receptors in the TGR(Tie2B(1)) rats represent a good model to study the role of functional B(1) receptors in the absence of any pathological stimulus. The data also show that K(Ca) channels are the final mediators of the hyperpolarizing responses to DBK and LPS. In addition, we suggest an interaction between the B1R and TLR4, since the hyperpolarization induced by LPS could be abolished in the presence of R715

FAMILIA NEREIDAE (POLYCHAETA) COMO BIOINDICADORA DE POLUIÇÃO ORGÂNICA EM PRAIAS DE SÃO LUÍS, MARANHÃO - BRASIL

Considerando-se a importância de comunidades bênticas na avaliação da qualidade ambiental, este trabalho teve como objetivo verificar a ocorrência de poliquetas nereídeos bioindicadores de poluição orgânica, em duas praias com diferentes níveis de ação antrópica, localizadas a noroeste da Ilha de São Luís, Maranhão. Os dados foram coletados em formações de sedimento fino consolidado na zona entre marés, compreendendo duas coletas para cada área estudada. As amostras foram obtidas com auxílio de formão e martelo. O resultado revela a presença marcante de um maior número de indivíduos nereídeos no local de maior enriquecimento orgânico, um indício do forte grau de comprometimento da praia da Ponta d’Areia.Palavras-chave: praias, poliquetas, bioindicadores, Maranhão.AbstractNereidaeFamily (Polycheta) as Bioindicator of Organic Pollution in Beaches of the Littoral of São Luis, Maranhão - BrazilBeing considered the importance of benthic communities in the evaluation of the environmental quality, this work had as objective verifies the occurrence of nereids polychaetes as bioindicators of organic pollution, in two beaches with different levels of antrophic influence, located to northwest of the Island of São Luis, Maranhão. The data were collected in formations of fine sediment consolidated in the intertidal zone. Two samplings were obtained for each studied area. The samples were obtained with chisel aid and hammer. The result reveals the outstanding presence of a larger number of nereids individuals  in the place of larger organic enrichment, an indication of the higher degree of compromising of the Ponta d’Areia beach.Key words: beaches, polychaetes, bioindicators, Maranhão