Study of hot-cathode magnetron ion gauge

Hot cathode magnetron ion gaug

Linking carbon economy and architectural development of peach trees by integrating markovian models into L-PEACH

International audienceno abstrac

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex. We have recently shown that PD-associated mutations in Fbxo7 disrupt mitochondrial autophagy (mitophagy), suggesting a role for Fbxo7 in modulating mitochondrial homeostasis. Here we report that Fbxo7 deficiency is associated with reduced cellular NAD(+) levels, which results in increased mitochondrial NADH redox index and impaired activity of complex I in the electron transport chain. Under these conditions of compromised respiration, mitochondrial membrane potential and ATP contents are reduced, and cytosolic reactive oxygen species (ROS) production is increased. ROS activates poly (ADP-ribose) polymerase (PARP) activity in Fbxo7-deficient cells. PARP inhibitor restores cellular NAD(+) content and redox index and ATP pool, suggesting that PARP overactivation is cause of decreased complex I-driven respiration. These findings bring new insight into the mechanism of Fbxo7 deficiency, emphasising the importance of mitochondrial dysfunction in PD

Groundwater recharge from heavy rainfall in the southwestern Lake Chad Basin: evidence from isotopic observations

We examine groundwater recharge processes and their relationship to rainfall intensity in the semi-arid, southwestern Lake Chad Basin of Nigeria using a newly compiled database of stable isotope data (δ2H, δ18O) from groundwater and rainfall. δ18O signatures in groundwater proximate to surface waters are enriched in 18O relative to regional rainfall and trace focused groundwater recharge from evaporated waters via ephemeral river discharge and Lake Chad; groundwater remote from river channels is comparatively depleted and associated with diffuse recharge, often via sand dunes. Stable isotope ratios of O and H (δ2H, δ18O) in groundwater samples regress to a value along the local meteoric waterline that is depleted relative to weighted mean composition of rainfall, consistent with rainfall exceeding the 60th percentile of monthly precipitation intensity. The observed bias in groundwater recharge to heavy monthly rainfall suggests that the intensification of tropical rainfall under global warming favours groundwater recharge in this basin