English Borrowings in Russian and Persian: A Comparative Study on Petroleum Terminology

The article reviews language borrowing as a cause of denominative variation in terminology and applies a descriptive and comparative approach to identify which roles receptor languages play in employment and adaptation of foreign terms

Современная лексикографическая деятельность в Иране

The article deals with the development of lexicographical activities in Iran, especially after the Islamic Revolution of 1979.В статье рассматривается развитие лексикографической деятельности в современном Иране, особенно после Исламской революции 1979 года

Motstånd och Mullvadar En studie om skolstyrning och implementering av de nationella genusmålen (Lpo94) i två skolor i Malmö stad

Syftet med denna studie har varit att analysera i vilken utsträckning och på vilket sätt som de nationella genusmålen i den verksamma läroplanen Lpo94 har implementerats i två enskilda skolor i Malmö stad. I och med detta har vi genomfört intervjuer med en utvecklingssekreterare på Barn- och Ungdomsavdelningen och två biträdande rektorer i två valda skolorna. Våra teori har bestått av begreppet ?interpellation? som ett analytiskt verktyg såsom reviderat av Judith Butler (1993) tillsammans med Tom Christensen m.fl:s (2005) tre organisationsteoretiska perspektiv; ett instrumentellt, kultur- och mytperspektiv. Metoderna vi använt oss av är diskursanalys som analysmetod och kvalitativ textanalys och intervjuer (innefattande fallstudier) som arbetsmetoder. Analysen visar att de nationella genusmålen som formuleras i Lpo94 instrumentellt sett existerar i folks medvetanden på kommunal såväl som lokal nivå. Även i det fall där man inte har något medvetet genusarbete så har man tillgång till en genusmässig begreppsapparat. Man har även själv lagt märke till genusmönster på sina skolor. I ett fall har man svårt att bryta ner de uppsatta genusmålen i praxis. Detta kan delvis förklaras av det rådande styrsystemets krav på skolorna att själva tolka genusmålen, samtidigt som man på skolorna saknar den genuskompetens som behövs för att göra en sådan tolkning. Nyckeln till förändring ligger i kompetensutveckling. Men det finns en mängd hinder från att en reell kompetensutveckling och ett förändringsarbete ska ske i stor skala, och de centrala aktörerna som utgör hindret är de som förväntas utföra förändringsarbetet; skolledarna och pedagogerna. Det existerar en förnekelsekultur bland dessa aktörer och de som jobbar med förändringsarbetet använder sig av gräsrotsstrategier för att tackla det motstånd förnekelsekulturen utgör

Epidemiology of glaucoma in sub-saharan Africa: prevalence, incidence and risk factors.

PURPOSE: The purpose of this study is to review the epidemiology of different types of glaucoma relevant to Sub-Saharan Africa (SSA) and to discuss the evidence regarding the risk factors for onset and progression of glaucoma, including risk factors for glaucoma blindness. METHODS: Electronic databases (PubMed, MedLine, African Journals Online- AJOL) were searched using the full text, Medical Subject Headings (MeSH) terms, author(s) and title to identify publications since 1982 in the following areas: population-based glaucoma prevalence and incidence studies in SSA and in African-derived black populations outside Africa; population-based prevalence and incidence of blindness and visual impairment studies in SSA including rapid assessment methods, which elucidate the glaucoma-specific blindness prevalence; studies of risk factors for glaucoma; and publications that discussed public health approaches for the control of glaucoma in Africa. RESULTS: Studies highlighted that glaucoma in SSA is a public health problem and predominantly open-angle glaucoma. It is the second-leading cause of blindness, has a high prevalence, an early onset and progresses more rapidly than in Caucasians. These factors are further compounded by poor awareness and low knowledge about glaucoma even by persons affected by the condition. CONCLUSION: Glaucoma care needs to be given high priority in Vision 2020 programs in Africa. Many questions remain unanswered and there is a need for further research in glaucoma in SSA in all aspects especially epidemiology and clinical care and outcomes involving randomized controlled trials. Genetic and genome-wide association studies may aid identification of high-risk groups. Social sciences and qualitative studies, health economics and health systems research will also enhance public health approaches for the prevention of blindness due to glaucoma

Immunogenic Mycobacterium africanum Strains Associated with Ongoing Transmission in The Gambia

In West Africa, Mycobacterium tuberculosis strains co-circulate with M. africanum, and both pathogens cause pulmonary tuberculosis in humans. Given recent findings that M. tuberculosis T-cell epitopes are hyperconserved, we hypothesized that more immunogenic strains have increased capacity to spread within the human host population. We investigated the relationship between the composition of the mycobacterial population in The Gambia, as measured by spoligotype analysis, and the immunogenicity of these strains as measured by purified protein derivative-induced interferon-γ release in ELISPOT assays of peripheral blood mononuclear cells. We found a positive correlation between strains with superior spreading capacity and their relative immunogenicity. Although our observation is true for M. tuberculosis and M. africanum strains, the association was especially pronounced in 1 M. africanum sublineage, characterized by spoligotype shared international type 181, which is responsible for 20% of all tuberculosis cases in the region and therefore poses a major public health threat in The Gambia

Performance evaluation of the Pima™ point-of-care CD4 analyser using capillary blood sampling in field tests in South Africa

<p>Abstract</p> <p>Background</p> <p>Point-of-care CD4 testing can provide immediate CD4 reporting at HIV-testing sites. This study evaluated performance of capillary blood sampling using the point-of-care Pima™ CD4 device in representative primary health care clinics doing HIV testing.</p> <p>Methods</p> <p>Prior to testing, prescribed capillary-sampling and instrument training was undertaken by suppliers across all sites. Matching venous EDTA samples were drawn throughout for comparison to laboratory predicate methodology (PLG/CD4). In Phase I, Pima™ cartridges were pipette-filled with EDTA venous blood in the laboratory (N = 100). In Phase II (N = 77), Pima™ CD4 with capillary sampling was performed by a single operator in a hospital-based antenatal clinic. During subsequent field testing, Pima™ CD4 with capillary sampling was performed in primary health care clinics on HIV-positive patients by multiple attending nursing personnel in a rural clinic (Phase-IIIA, N = 96) and an inner-city clinic (Phase-IIIB, N = 139).</p> <p>Results</p> <p>Pima™ CD4 compared favourably to predicate/CD4 when cartridges were pipette-filled with venous blood (bias -17.3 ± STDev = 36.7 cells/mm³; precision-to-predicate %CV < 6%). Decreased precision of Pima™ CD4 to predicate/CD4 (varying from 17.6 to 28.8%SIM CV; mean bias = 37.9 ± STDev = 179.5 cells/mm³) was noted during field testing in the hospital antenatal clinic. In the rural clinic field-studies, unacceptable precision-to-predicate and positive bias was noted (mean 28.4%SIM CV; mean bias = +105.7 ± STDev = 225.4 cells/mm³). With additional proactive manufacturer support, reliable performance was noted in the subsequent inner-city clinic field study where acceptable precision-to-predicate (11%SIM CV) and less bias of Pima™ to predicate was shown (BA bias ~11 ± STDev = 69 cells/mm³).</p> <p>Conclusions</p> <p>Variable precision of Pima™ to predicate CD4 across study sites was attributable to variable capillary sampling. Poor precision was noted in the outlying primary health care clinic where the system is most likely to be used. Stringent attention to capillary blood collection technique is therefore imperative if technologies like Pima™ are used with capillary sampling at the POC. Pima™ CD4 analysis with venous blood was shown to be reproducible, but testing at the point of care exposes operators to biohazard risk related to uncapping vacutainer samples and pipetting of blood, and is best placed in smaller laboratories using established principles of Good Clinical Laboratory Practice. The development of capillary sampling quality control methods that assure reliable CD4 counts at the point of care are awaited.</p

Timing of the Infancy-Childhood Growth Transition in Rural Gambia.

The Karlberg model of human growth describes the infancy, childhood, and puberty (ICP) stages as continuous and overlapping, and defined by transitions driven by sequential additional effects of several endocrine factors that shape the growth trajectory and resultant adult size. Previous research has suggested that a delayed transition from the infancy to the childhood growth stage contributes to sub-optimal growth outcomes. A new method developed to analyze the structure of centile crossing in early life has emerged as a potential tool for identifying the infancy-childhood transition (ICT), through quantifying patterns of adjacent monthly weight-for-age z-score (WAZ) deviation correlations. Using this method, the infancy-childhood transition was identified as taking place at around 12 months of age in two cohorts of UK infants. Here, we apply this method to data collected as part of a longitudinal growth study in rural Gambia [the Hormonal and Epigenetic Regulators of Growth, or HERO-G study, N = 212 (F = 99, M = 113)], in order to identify the ICT and assess whether timing of this transition differs across groups based on sex or birth seasonality. We calculated Pearson correlation coefficients for adjacent monthly WAZ score deviations. Based on the patterns of change in the correlation structure over time, our results suggest that the infancy-childhood transition occurs at around 9 months of age in rural Gambian infants. This points to an accelerated ICT compared to UK infants, rather than a delayed ICT. A comparatively later transition, seen in UK infants, allows maximal extension of the high rates of growth during the infancy stage; an earlier transition as seen in Gambian infants cuts short this period of rapid growth, potentially impacting on growth outcomes in childhood while diverting energy into other processes critical to responses to acute infectious challenges. Growth in later developmental stages in this population offers an extended window for catch-up

Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension

YesThe geographically restricted Mycobacterium africanum lineages (MAF) are primarily found in West Africa, where they account for a significant proportion of tuberculosis. Despite this phenomenon, little is known about the co-evolution of these ancient lineages with West Africans. MAF and M. tuberculosis sensu stricto lineages (MTB) differ in their clinical, in vitro and in vivo characteristics for reasons not fully understood. Therefore, we compared genomes of 289 MAF and 205 MTB clinical isolates from the 6 main human-adapted M. tuberculosis complex lineages, for mutations in their Electron Transport Chain and Central Carbon Metabolic pathway in order to explain these metabolic differences. Furthermore, we determined, in silico, whether each mutation could affect the function of genes encoding enzymes in these pathways. We found more mutations with the potential to affect enzymes in these pathways in MAF lineages compared to MTB lineages. We also found that similar mutations occurred in these pathways between MAF and some MTB lineages. Generally, our findings show further differences between MAF and MTB lineages that may have contributed to the MAF clinical and growth phenotype and indicate potential adaptation of MAF lineages to a distinct ecological niche, which we suggest includes areas characterized by low oxygen tension.European Research CouncilINTERRUPTB starting grant nr. 311725 (to BdJ, FG, CM, LR, BO, MA) and The UK Medical Research Council and the European & Developing Countries Clinical Trials Partnership (EDCTP) Grant No. CB. 2007. 41700.007.Research Development Fund Publication Prize Award winner, January 2020

Anti-plane interfacial crack with functionally graded coating: static and dynamic

The anti-plane displacement discontinuity method is applied to establish the Fredholm integral equation of the first kind for the orthotropic Functionally Graded Material (FGM) coatings subjected to static/dynamic shears. The shear modulus and mass density are assumed to vary exponentially through the thickness. The static and dynamic fundamental solutions with anti-plane displacement discontinuity are derived for orthotropic FGM coating by using Fourier transform method and Laplace transform method. It has been shown that the transformed fundamental solution with orthotropic coatings has the same order of hyper-singularity as in the static case, i.e. O(1/r2), and the Chebyshev polynomials of the second kind are used to solve the integral equations numerically. The time dependent stress intensity factors are obtained directly from the coefficients of the Chebyshev polynomials with the aid of Durbin’s Laplace transform inversion method. A comparative study of FGM versus homogeneous coating is conducted, and the dependence of the stress intensity factors in the coating/substrate system on the material property (orthotropic) and thickness of coating is examined. Two examples including the static/dynamic loads are given as benchmarks for the numerical methods and application in composite engineering