NCI-MATCH Arms N & P: Phase II study of PI3K beta inhibitor GSK2636771 in patients (pts) with cancers (ca) with PTEN mutation/deletion (mut/del) or PTEN protein loss

Background: The NCI-MATCH trial is the largest national study (1173 sites) for ptswith relapsed/ refractory solid tumors, lymphomas and myeloma, which assigns tar-geted therapies based on individual tumor molecular alterations detected using theadapted Oncomine AmpliSeq panel (143 genes) and immunohistochemistry (IHC).We hypothesized that patients with PTEN-deficient cancers enrolled to Arms N and Pmay benefit from treatment with the PI3K beta-selective inhibitor GSK2636771. Methods: Eligibility: relapsed/refractory ca, good end-organ function, and ECOG PS ≤ 1. Pts were screened for molecular alterations by centralized testing on fresh tumor biopsy and had deleterious PTEN mut/del without loss of expression (Arm N) or complete loss of cytoplasmic and nuclear PTEN staining on IHC (Arm P), and no other aberrations activating the PI3K/MTOR and MAPK pathways (mut in PIK3CA, PIK3R1, BRAF, KRAS, AKT1, TSC1/2, mTOR, RHEB, NF2, NRAS, HRAS). Pts received GSK2636771 400mg/day (28-days cycles). RECIST 1.1 overall response rate (ORR) was the primary endpoint. Results: Of 59 enrolled pts, 56 were eligible and received treatment. Of 22 pts with PTEN mut/del (Arm N: 6 uterine, 2 breast, 2 prostate, 2 head/neck ca, 10 other), all are off treatment as of analysis (14 disease progression, 4 for adverse events [AEs], 4 other). One pt (4.5%) with prostate ca (PTEN deletion, MPRSS2-ERG fusion) attained a partial response (-42%). Of 7 (32%) pts with stable disease (SD), 2 had SD \u3e 6 months (uterine leiomyosarcoma; endometrial carcinoma). Of 34 pts with loss of PTEN protein by IHC (Arm P: 7 prostate, 6 breast, 3 squamous anal ca, 2 cholangiocarcinoma, 16 other), all are off treatment as of analysis (26 disease progression, 4 for AE, 4 other). Of 9 (37.5%) pts with SD, 3 had SD \u3e 6 months (prostate cancer; squamous bladder cancer, squamous anal cancer). Median progression-free survival was 1.8 months for both arms. Gr ≥ 3 treatment-related (tr) reversible toxicities were experienced by 30% (7) and 20% (7) of pts in arms N and P, respectively. No tr Gr 5 toxicities were observed in either arm. Conclusions: Single agent GSK2636771 has very modest activity in ca with PTEN gene mutation/deletion and/or PTEN protein loss

Report on Tests and Measurements of Hadronic Interaction Properties with Air Showers

We present a summary of recent tests and measurements of hadronic interaction properties with air showers. This report has a special focus on muon density measurements. Several experiments reported deviations between simulated and recorded muon densities in extensive air showers, while others reported no discrepancies. We combine data from eight leading air shower experiments to cover shower energies from PeV to tens of EeV. Data are combined using the z-scale, a unified reference scale based on simulated air showers. Energy-scales of experiments are cross-calibrated. Above 10 PeV, we find a muon deficit in simulated air showers for each of the six considered hadronic interaction models. The deficit is increasing with shower energy. For the models EPOS-LHC and QGSJet-II.04, the slope is found significant at 8 sigma.Comment: Submitted to the Proceedings of UHECR201

Nuclear structure in strong magnetic fields: nuclei in the crust of a magnetar

Covariant density functional theory is used to study the effect of strong magnetic fields, up to the limit predicted for neutron stars (for magnetars $B \approx10^{18}$G), on nuclear structure. All new terms in the equation of motion resulting from time reversal symmetry breaking by the magnetic field and the induced currents, as well as axial deformation, are taken into account in a self-consistent fashion. For nuclei in the iron region of the nuclear chart it is found that fields in the order of magnitude of $10^{17}$G significantly affect bulk properties like masses and radii.Comment: 9 pages, 6 figure

Priority sites for wildfowl conservation in Mexico

A set of priority sites for wildfowl conservation in Mexico was determined using contemporary count data (1991–2000) from the U.S. Fish & Wildlife Service mid-winter surveys. We used a complementarity approach implemented through linear integer programming that addresses particular conservation concerns for every species included in the analysis and large fluctuations in numbers through time. A set of 31 priority sites was identified, which held more than 69% of the mid-winter count total in Mexico during all surveyed years. Six sites were in the northern highlands, 12 in the central highlands, six on the Gulf of Mexico coast and seven on the upper Pacific coast. Twenty-two sites from the priority set have previously been identified as qualifying for designation as wetlands of international importance under the Ramsar Convention and 20 sites are classified as Important Areas for Bird Conservation in Mexico. The information presented here provides an accountable, spatially-explicit, numerical basis for ongoing conservation planning efforts in Mexico, which can be used to improve existing wildfowl conservation networks in the country and can also be useful for conservation planning exercises elsewhere

Beneficios del entrenamiento vibratorio en el sistema neuromuscular de los adultos mayores

Introduction: The vibration training may be an option for optimal intervention to prevent muscle loss in older adults.Objective: To assess the effectiveness of vibration training in the neuromuscular system of the elderly.Methods: Literature review in Medline, CINAHL, WOS and PEDro data by combining the descriptors of Medical Subject Headings concerning vibration training, muscle strength, muscle mass and seniors.Results: Studies located on the vibration training in older people were done as either the only intervention, or in combination with other strength exercises, aerobic, balance or flexibility. The diversity of protocols hinders comparison between studies.Conclusion: WBV training proves to be a healthy method, adequate and effective in the strength of the elderly population, but with similar results to conventional resistance exercise.Introducción: El entrenamiento vibratorio puede ser una opción de intervención óptima para prevenir la pérdida de masa muscular en adultos mayores. Objetivo: Comprobar la efectividad del entrenamiento vibratorio en el sistema neuromuscular de los adultos mayores.Material y método: Revisión bibliográfica en las bases de datos Medline, CINAHL, WOS y PEDro, mediante la combinación de los descriptores del Medical Subjects Headings referentes a entrenamiento vibratorio, fuerza muscular, masa muscular y personas mayores. Resultados: Los estudios localizados sobre el entrenamiento vibratorio en personas mayores se realizaron, bien como única intervención, o en combinación con otro tipo de ejercicios de fuerza, aeróbicos,  de equilibrio o de flexibilidad. La diversidad de protocolos empleados dificulta una comparación entre estudios.Conclusión: El entrenamiento con plataformas vibratorias demuestra ser un método de entrenamiento de la fuerza seguro, adecuado y eficaz para la población de mayor edad, pero con resultados similares al ejercicio de resistencia convencional