104 research outputs found
Shear-free radiating collapse and conformal flatness
Here we study some general properties of spherical shear-free collapse. Its
general solution when imposing conformal flatness is reobtained [1,2] and
matched to the outgoing Vaidya spacetime. We propose a simple model satisfying
these conditions and study its physical consequences. Special attention
deserve, the role played by relaxational processes and the conspicuous link
betweeen dissipation and density inhomogeneity.Comment: 13 pages Latex. Some misprints in eqs.(17), (30) and (35) have been
correcte
Nonadiabatic charged spherical gravitational collapse
We present a complete set of the equations and matching conditions required
for the description of physically meaningful charged, dissipative, spherically
symmetric gravitational collapse with shear. Dissipation is described with both
free-streaming and diffusion approximations. The effects of viscosity are also
taken into account. The roles of different terms in the dynamical equation are
analyzed in detail. The dynamical equation is coupled to a causal transport
equation in the context of Israel-Stewart theory. The decrease of the inertial
mass density of the fluid, by a factor which depends on its internal
thermodynamic state, is reobtained, with the viscosity terms included. In
accordance with the equivalence principle, the same decrease factor is obtained
for the gravitational force term. The effect of the electric charge on the
relation between the Weyl tensor and the inhomogeneity of energy density is
discussed.Comment: 23 pages, Latex. To appear in Phys. Rev. D. Some references correcte
Generalised equilibrium of cosmological fluids in second-order thermodynamics
Combining the second-order entropy flow vector of the causal Israel-Stewart
theory with the conformal Killing-vector property of , where
is the four-velocity of the medium and T its equilibrium temperature, we
investigate generalized equilibrium states for cosmological fluids with
nonconserved particle number. We calculate the corresponding equilibrium
particle production rate and show that this quantity is reduced compared with
the results of the previously studied first-order theory. Generalized
equilibrium for massive particles turns out to be compatible with a dependence
of the fluid energy density on the scale factor a
of the Robertson-Walker metric and may be regarded as a realization of
so-called K-matter.Comment: 17 pages, iopfts.tex file, submitted to Class. Quantum Gra
BMJ Open
INTRODUCTION: Guidelines concerning the follow-up of subjects occupationally exposed to lung carcinogens, published in France in 2015, recommended the setting up of a trial of low-dose chest CT lung cancer screening in subjects at high risk of lung cancer. OBJECTIVE: To evaluate the organisation of low-dose chest CT lung cancer screening in subjects occupationally exposed to lung carcinogens and at high risk of lung cancer. METHODS AND ANALYSIS: This trial will be conducted in eight French departments by six specialised reference centres (SRCs) in occupational health. In view of the exploratory nature of this trial, it is proposed to test initially the feasibility and acceptability over the first 2 years in only two SRCs then in four other SRCs to evaluate the organisation. The target population is current or former smokers with more than 30 pack-years (who have quit smoking for less than 15 years), currently or previously exposed to International Agency for Research on Cancer group 1 lung carcinogens, and between the ages of 55 and 74 years. The trial will be conducted in the following steps: (1) identification of subjects by a screening invitation letter; (2) evaluation of occupational exposure to lung carcinogens; (3) evaluation of the lung cancer risk level and verification of eligibility; (4) screening procedure: annual chest CT scans performed by specialised centres and (5) follow-up of CT scan abnormalities. ETHICS AND DISSEMINATION: This protocol study has been approved by the French Committee for the Protection of Persons. The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings. TRIAL REGISTRATION NUMBER: NCT03562052; Pre-results
A Viable Hypomorphic Allele of the Essential IMP3 Gene Reveals Novel Protein Functions in Saccharomyces cerevisiae
In Saccharomyces cerevisiae, the essential IMP3 gene encodes a component of the SSU processome, a large ribonucleoprotein complex required for processing of small ribosomal subunit RNA precursors. Mutation of the IMP3 termination codon to a sense codon resulted in a viable mutant allele producing a C-terminal elongated form of the Imp3 protein. A strain expressing the mutant allele displayed ribosome biogenesis defects equivalent to IMP3 depletion. This hypomorphic allele represented a unique opportunity to investigate and better understand the Imp3p functions. We demonstrated that the +1 frameshifting was increased in the mutant strain. Further characterizations revealed involvement of the Imp3 protein in DNA repair and telomere length control, pointing to a functional relationship between both pathways and ribosome biogenesis
Biological Roles of the Podospora anserina Mitochondrial Lon Protease and the Importance of Its N-Domain
Mitochondria have their own ATP-dependent proteases that maintain the functional state of the organelle. All multicellular eukaryotes, including filamentous fungi, possess the same set of mitochondrial proteases, unlike in unicellular yeasts, where ClpXP, one of the two matricial proteases, is absent. Despite the presence of ClpXP in the filamentous fungus Podospora anserina, deletion of the gene encoding the other matricial protease, PaLon1, leads to lethality at high and low temperatures, indicating that PaLON1 plays a main role in protein quality control. Under normal physiological conditions, the PaLon1 deletion is viable but decreases life span. PaLon1 deletion also leads to defects in two steps during development, ascospore germination and sexual reproduction, which suggests that PaLON1 ensures important regulatory functions during fungal development. Mitochondrial Lon proteases are composed of a central ATPase domain flanked by a large non-catalytic N-domain and a C-terminal protease domain. We found that three mutations in the N-domain of PaLON1 affected fungal life cycle, PaLON1 protein expression and mitochondrial proteolytic activity, which reveals the functional importance of the N-domain of the mitochondrial Lon protease. All PaLon1 mutations affected the C-terminal part of the N-domain. Considering that the C-terminal part is predicted to have an α helical arrangement in which the number, length and position of the helices are conserved with the solved structure of its bacterial homologs, we propose that this all-helical structure participates in Lon substrate interaction
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