Tanaka-Tagoshi Parametrization of post-1PN Spin-Free Gravitational Wave Chirps: Equispaced and Cardinal Interpolated Lattices For First Generation Interferometric Antennas

The spin-free binary-inspiral parameter-space introduced by Tanaka and Tagoshi to construct a uniformly-spaced lattice of templates at (and possibly beyond) $2.5PN$ order is shown to work for all first generation interferometric gravitational wave antennas. This allows to extend the minimum-redundant cardinal interpolation techniques of the correlator bank developed by the Authors to the highest available order PN templates. The total number of 2PN templates to be computed for a minimal match $\Gamma=0.97$ is reduced by a factor 4, as in the 1PN case.Comment: 9 pages, 8 figures, 3 tables, accepted for publication in Phys. Rev.

Rejection Properties of Stochastic-Resonance-Based Detectors of Weak Harmonic Signals

In (V. Galdi et al., Phys. Rev. E57, 6470, 1998) a thorough characterization in terms of receiver operating characteristics (ROCs) of stochastic-resonance (SR) detectors of weak harmonic signals of known frequency in additive gaussian noise was given. It was shown that strobed sign-counting based strategies can be used to achieve a nice trade-off between performance and cost, by comparison with non-coherent correlators. Here we discuss the more realistic case where besides the sought signal (whose frequency is assumed known) further unwanted spectrally nearby signals with comparable amplitude are present. Rejection properties are discussed in terms of suitably defined false-alarm and false-dismissal probabilities for various values of interfering signal(s) strength and spectral separation.Comment: 4 pages, 5 figures. Misprints corrected. PACS numbers added. RevTeX

A Nearly Minimum Redundant Correlator Interpolation Formula for Gravitational Wave Chirp Detection

An absolute lower bound on the number of templates needed to keep the fitting factor above a prescribed minimal value $\Gamma$ in correlator bank detection of (newtonian) gravitational wave chirps from unknown inspiraling compact binary sources is derived, resorting to the theory of quasi-bandlimited functions in the $L^\infty$ norm. An explicit nearly-minimum redundant cardinal-interpolation formula for the (reduced, noncoherent) correlator is introduced. Its computational burden and statistical properties are compared to those of the plain lattice of (reduced, noncoherent) correlators, for the same $\Gamma$. Extension to post-newtonian models is outlined

PPF dependent fixed point in modified Razumikhin class with applications

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How Many Templates for GW Chirp Detection? The Minimal-Match Issue Revisited

In a recent paper dealing with maximum likelihood detection of gravitational wave chirps from coalescing binaries with unknown parameters we introduced an accurate representation of the no-signal cumulative distribution of the supremum of the whole correlator bank. This result can be used to derive a refined estimate of the number of templates yielding the best tradeoff between detector's performance (in terms of lost signals among those potentially detectable) and computational burden.Comment: submitted to Class. Quantum Grav. Typing error in eq. (4.8) fixed; figure replaced in version

SIVsm Quasispecies Adaptation to a New Simian Host

Despite the potential for infectious agents harbored by other species to become emerging human pathogens, little is known about why some agents establish successful cross-species transmission, while others do not. The simian immunodeficiency viruses (SIVs), certain variants of which gave rise to the human HIV-1 and HIV-2 epidemics, have demonstrated tremendous success in infecting new host species, both simian and human. SIVsm from sooty mangabeys appears to have infected humans on several occasions, and was readily transmitted to nonnatural Asian macaque species, providing animal models of AIDS. Here we describe the first in-depth analysis of the tremendous SIVsm quasispecies sequence variation harbored by individual sooty mangabeys, and how this diverse quasispecies adapts to two different host species—new nonnatural rhesus macaque hosts and natural sooty mangabey hosts. Viral adaptation to rhesus macaques was associated with the immediate amplification of a phylogenetically related subset of envelope (env) variants. These variants contained a shorter variable region 1 loop and lacked two specific glycosylation sites, which may be selected for during acute infection. In contrast, transfer of SIVsm to its natural host did not subject the quasispecies to any significant selective pressures or bottleneck. After 100 d postinfection, variants more closely representative of the source inoculum reemerged in the macaques. This study describes an approach for elucidating how pathogens adapt to new host species, and highlights the particular importance of SIVsm env diversity in enabling cross-species transmission. The replicative advantage of a subset of SIVsm variants in macaques may be related to features of target cells or receptors that are specific to the new host environment, and may involve CD4-independent engagement of a viral coreceptor conserved among primates

Enhanced heterogeneously catalyzed Suzuki–Miyaura reaction over SiliaCat Pd(0)

The SiliaCat Pd(0) solid catalyst can be efficiently employed in the Suzuki–Miyaura cross-coupling of an ample variety of haloarenes, including economically viable chloroarenes. The catalyst can be extensively recycled without loss of activity and with low leaching of valued palladium, opening the route to widespread utilization of the method to afford high yields of biaryls devoid of contaminating by-products

Optimum Placement of Post-1PN GW Chirp Templates Made Simple at any Match Level via Tanaka-Tagoshi Coordinates

A simple recipe is given for constructing a maximally sparse regular lattice of spin-free post-1PN gravitational wave chirp templates subject to a given minimal match constraint, using Tanaka-Tagoshi coordinates.Comment: submitted to Phys. Rev.

Correlator Bank Detection of GW chirps. False-Alarm Probability, Template Density and Thresholds: Behind and Beyond the Minimal-Match Issue

The general problem of computing the false-alarm rate vs. detection-threshold relationship for a bank of correlators is addressed, in the context of maximum-likelihood detection of gravitational waves, with specific reference to chirps from coalescing binary systems. Accurate (lower-bound) approximants for the cumulative distribution of the whole-bank supremum are deduced from a class of Bonferroni-type inequalities. The asymptotic properties of the cumulative distribution are obtained, in the limit where the number of correlators goes to infinity. The validity of numerical simulations made on small-size banks is extended to banks of any size, via a gaussian-correlation inequality. The result is used to estimate the optimum template density, yielding the best tradeoff between computational cost and detection efficiency, in terms of undetected potentially observable sources at a prescribed false-alarm level, for the simplest case of Newtonian chirps.Comment: submitted to Phys. Rev.

Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3

The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms of inflammation or bacterial entry. During infection of intestinal epithelial cells, SipA was found to be responsible for the early activation of caspase-3, an enzyme that is required for SipA cleavage at a specific recognition motif that divided the protein into its two functional domains and activated SipA in a manner necessary for pathogenicity. Other caspase-3 cleavage sites identified in S. Typhimurium appeared to be restricted to secreted effector proteins, which indicates that this may be a general strategy used by this pathogen for processing of its secreted effectors