A method for volume stabilization of single, dye-doped water microdroplets with femtoliter resolution

A self-control mechanism that stabilizes the size of Rhodamine B-doped water microdroplets standing on a superhydrophobic surface is demonstrated. The mechanism relies on the interplay between the condensation rate that was kept constant and evaporation rate induced by laser excitation which critically depends on the size of the microdroplets. The radii of individual water microdroplets (>5 um) stayed within a few nanometers during long time periods (up to 455 seconds). By blocking the laser excitation for 500 msec, the stable volume of individual microdroplets was shown to change stepwise.Comment: to appear in the J. Op. Soc. Am.

Experimental investigation of the effects of beach drainage on erosion in fine-grained beaches

Plajlar ince kumlardan iri kayalara kadar değişen büyüklükte kayaların birikmesiyle oluşmuş jeolojik bölgelerdir. Plajlar kara, hava ve deniz birleşiminde yer almakta olup morfolojileri dalga mekaniği, katı madde özellikleri ve mekaniği, plaj yeraltı suyu akımı ve mekaniği ile rüzgar etkilerinin etkileşimine bağlıdır. Sahil drenajı, sahil altına yerleştirilen perfore drenaj boruları vasıtasıyla dalga ve yeraltı sularının drene edilmesi ve böylece yeraltı su seviyesinin düşürülmesi ile sızma oranının arttırılması prensibine dayanır. Araştırmada ince taneli kuma sahip sahillerde sızma oranının arttırılması ile erozyonun nasıl değişeceği deneysel olarak incelenmiştir. Çalışmanın amacı değişik dalga özelliklerinin etkisinde drenaj borusunun farklı konumlarında profil şeklinin ve drenaj debisinin tayin edilmesidir. Bu amaçla fiziksel bir model geliştirilmiş ve basit analitik çözümler önerilmiştir. Bu çalışmalar daha sonra düzenli dalga koşullarında yapılan laboratuvar çalışmaları ile karşılaştırılmıştır. Drenaj debisinin tahmini, inşaa edilecek su toplama kuyusunun hesabında ve bu kuyudan suları denize deşarj edecek pompa kapasitesinin tayininde kullanılmaktadır. Öte yandan, değişik dalga ve drenaj borusu yerleşim yerleri için erozyon alanının tahmin edilmesi, kıyı duvarları ve kıyı kaplamaları gibi çeşitli yapıların stabilitelerinin belirlenmesi açısından önemlidir. Bu çalışmada hem drenaj debisi hem de erozyon alanı parametrelerinin tahmini için denklemler önerilmiştir. Sahil drenajı ile erozyon alanında azalma yaşanmıştır. Bunun nedeni olarak yer altı su seviyesinin düşmesi ile sızma oranında artma ve buna mukabil katı madde efektif ağırlığında artış söylenebilir. Profil verileri incelendiğinde erozyon alanındaki artışın en önemli nedeni ise dalga tırmanma yüksekliğinde yaşanan azalma görülmüştür.  Anahtar Kelimeler: Sahil drenajı, erozyon, stabilizasyon.Beaches play important roles in both the dissipation of wave energy and for the recreational purposes. They are generally in dynamic equilibrium. But, due to increasing industrial activities and population, human interference into the beaches occurs and the dynamic equilibrium deteriorates. In order to control the cross-shore and alongshore sediment transport in eroding beaches, some structures like breakwaters, groins, seawalls are constructed. These structures are composed of massive concrete blocks which lead to loss in aesthetic vision. Moreover, these structures are very difficult to relocate after construction. Beach drainage is an erosion control method studied in-situ, laboratory and numerically and offers an alternative to massive coastal control structures. Main philosophy lying under this method is lowering the water table and increasing the infiltration through the sediment matrix. As the infiltration rate increases, the probability of liquefaction and effective weight reduction of sediments will be reduced. Also, water that infiltrates during the wave runup will lead to reduction in flow velocity during both in runup and run-down phases. This reduction in flow velocity will lead to reduction in shear stresses. Recently, some numerical studies claim that for fine sediments, in case of infiltration, erosion occurs due to offshore migration of sediments. On the other hand, reports of in-situ investigations reveal that, in case of infiltration either the beach accretes or the erosion is reduced. Experiments are conducted in a narrow flume with 22m in length, 1m in width and 80cm in depth. Slope of beach profile is always kept constant (1:5), the profile and drainage flow rate data are measured.  The median grain size of the sediment is d50=0.3 mm. The diameter of the drainage pipe is 50mm and is laid all width of the flume. The pipe is perforated in 8mm holes to allow the water suction. Geotextile sheet is wrapped over the pipe to prevent the holes from sediment clogging. 6 drainage pipe locations are determined; beach profiles and drainage flow rates are measured in these locations. Between the beach head and the ground water trench, geotextile filter layer is placed to prevent clogging of the holes, which allow the ground water flow through the beach. Ground water level is always kept constant in all experiments as the same as the still water level. According to the experimental analysis, the waves which have lower height than 5.5 cm do not result in erosion in the profile in no-drain case. The area of the erosion is almost linearly increasing with wave height. In case of drainage, the wave height which does not result in erosion in the profile is observed as 8cm. Center of gravity of the offshore bar migrates landwards as the drainage pipe location approaches the intersection of beach profile and still water line. There is no direct relation between the drainage flow rate and erosion area. The important factor is that whether the runup/rundown wave water or the existing ground water is drained. The ground water is drained as the pipe location migrates landwards. According to the experimental analysis results, the most obvious reduction in the erosion area is observed when the pipe is placed in location (2). When the data measured in location (2) is compared with no-drain data, erosion area reduction rate is reduced when the wave height is increased. When the wave height is increased up to 25 cm, drainage has no advantage to reduce erosion Dimensionless drainage flow rate and dimensionless erosion area parameters are derived analytically by using the data measured in pipe locations of 1, 3, 4 and 5. Derived equations are verified by using locations 2 and 6. The increase in the infiltration rate by lowering the water table leads to reduction in the effective weight of the sediments and decrease in the flow velocity of the runup/rundown swash flows. When the profile graphs are investigated, the main reason for the erosion reduction should be the reduction of the wave runup height. Increase in the infiltration rate leads to reduction of the wave runup wave flow velocity and quantity, resulting in the decrease of runup limit of water waves. In the down-rush phase, the flow velocity is also reduced and the ability to carry sediments is decreased. Keywords: Beach drainage, dewatering, erosion, stabilisation

Histopathologic and immunohistochemical investigations of dental abscess formed in maxillofacial area

Background: An abscess is a pocket of pus that forms around the root of an infected tooth. In this study, we aimed to investigate the extracellular matrix proteases ADAMTS1, ADAMTS4, osteonectin, and osteopontin expressions in abscess fluid cells in jaws after implantation and prosthesis operation. Materials and methods: In this clinical study, abscess fluids belonging to 17 patients who applied to the Department of Oral and Maxillofacial Surgery were examined histopathologically and immunohistochemically. In the histopathological examination of the abscess fluid, separation of chromatin bridges in the nuclei of neutrophil cells, pyknosis and apoptotic changes in the nucleus, degenerative change in the cytoplasm, and occasional vacuolar structures were observed. Results: The positive reaction of ADAMTS1 was observed in fibroblast cells, plasma cells, and macrophage cells. The positive reaction of ADAMTS4 was observed in fibroblast cells, osteoclast cells, and some apoptotic leukocyte cells. Osteopontin expression in osteoclastic cells and polymorphonuclear cells was defined as positive. Osteonectin expression was positive in polymorphonuclear leukocytes and hypertrophic fibroblast cells. Conclusions: ADAMTS1 and ADAMTS4 may induce bone destruction with its distinctive property in alveolar bone resorption, which promotes the activation of osteoclasts, which can accelerate the destruction of the extracellular matrix in the acute phase. Furthermore, osteoclastic activity increased with the increase of osteonectin and osteopontin protein expression due to inflammation in the abscess cases

Ultrafast nonlocal control of spontaneous emission

Solid-state cavity quantum electrodynamics systems will form scalable nodes of future quantum networks, allowing the storage, processing and retrieval of quantum bits, where a real-time control of the radiative interaction in the cavity is required to achieve high efficiency. We demonstrate here the dynamic molding of the vacuum field in a coupled-cavity system to achieve the ultrafast nonlocal modulation of spontaneous emission of quantum dots in photonic crystal cavities, on a timescale of ~200 ps, much faster than their natural radiative lifetimes. This opens the way to the ultrafast control of semiconductor-based cavity quantum electrodynamics systems for application in quantum interfaces and to a new class of ultrafast lasers based on nano-photonic cavities.Comment: 15 pages, 4 figure

MOF-associated complexes ensure stem cell identity and Xist repression

Histone acetyl transferases (HATs) play distinct roles in many cellular processes and are frequently misregulated in cancers. Here, we study the regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells (ESCs) and neuronal progenitors. We find that both complexes influence transcription by targeting promoters and TSS-distal enhancers. In contrast to flies, the MSL complex is not exclusively enriched on the X chromosome, yet it is crucial for mammalian X chromosome regulation as it specifically regulates Tsix, the major repressor of Xist lncRNA. MSL depletion leads to decreased Tsix expression, reduced REX1 recruitment, and consequently, enhanced accumulation of Xist and variable numbers of inactivated X chromosomes during early differentiation. The NSL complex provides additional, Tsix-independent repression of Xist by maintaining pluripotency. MSL and NSL complexes therefore act synergistically by using distinct pathways to ensure a fail-safe mechanism for the repression of X inactivation in ESCs

Turner syndrome and associated problems in turkish children: A multicenter study

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology

Beyond national narratives? : centenary histories, the First World War and the Armenian Genocide

In April 2015 the centenary of the Armenian Genocide was commemorated. Just like the First World War centenary, this anniversary has provoked a flurry of academic and public interest in what remains a highly contested history. This article assesses the state of the current historiography on the fate of the Ottoman Armenians. It focuses on the possibilities for moving beyond the national narratives which continue to dominate the field, in particular through connecting the case of the Armenian Genocide to what has been termed a ‘transnational turn’ in the writing of the history of the First World War