2,305 research outputs found
The Environmental Implications of Redistributive Land Reform
Acknowledgements Thank you to the two anonymous referees who commented on this piece. Conflict of interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) received no financial support for the research, authorship, and/or publication of this article.Peer reviewedPostprin
Jamming transition in a two-dimensional open granular pile with rolling resistance
We present a molecular dynamics study of the jamming/unjamming transition in
two-dimensional granular piles with open boundaries. The grains are modeled by
viscoelastic forces, Coulomb friction and resistance to rolling. Two models for
the rolling resistance interaction were assessed: one considers a constant
rolling friction coefficient, and the other one a strain dependent coefficient.
The piles are grown on a finite size substrate and subsequently discharged
through an orifice opened at the center of the substrate. Varying the orifice
width and taking the final height of the pile after the discharge as the order
parameter, one can devise a transition from a jammed regime (when the grain
flux is always clogged by an arch) to a catastrophic regime, in which the pile
is completely destroyed by an avalanche as large as the system size. A finite
size analysis shows that there is a finite orifice width associated with the
threshold for the unjamming transition, no matter the model used for the
microscopic interactions. As expected, the value of this threshold width
increases when rolling resistance is considered, and it depends on the model
used for the rolling friction.Comment: 9 pages, 6 figure
Efficiently Clustering Very Large Attributed Graphs
Attributed graphs model real networks by enriching their nodes with
attributes accounting for properties. Several techniques have been proposed for
partitioning these graphs into clusters that are homogeneous with respect to
both semantic attributes and to the structure of the graph. However, time and
space complexities of state of the art algorithms limit their scalability to
medium-sized graphs. We propose SToC (for Semantic-Topological Clustering), a
fast and scalable algorithm for partitioning large attributed graphs. The
approach is robust, being compatible both with categorical and with
quantitative attributes, and it is tailorable, allowing the user to weight the
semantic and topological components. Further, the approach does not require the
user to guess in advance the number of clusters. SToC relies on well known
approximation techniques such as bottom-k sketches, traditional graph-theoretic
concepts, and a new perspective on the composition of heterogeneous distance
measures. Experimental results demonstrate its ability to efficiently compute
high-quality partitions of large scale attributed graphs.Comment: This work has been published in ASONAM 2017. This version includes an
appendix with validation of our attribute model and distance function,
omitted in the converence version for lack of space. Please refer to the
published versio
Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1
The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among the newly identified partners, five are known to play direct and important roles in transcriptional regulation. Of these, the Myc-interacting zinc finger protein-1 (MIZ-1) is a transcription factor initially characterized as a binding partner of MYC. MIZ-1 activates the transcription of a number of target genes including the cell cycle inhibitor CDKN2B. Focusing on the EBNA3A/MIZ-1 interaction we demonstrate that binding occurs in EBV-infected cells expressing both proteins at endogenous physiological levels and that in the presence of EBNA3A, a significant fraction of MIZ-1 translocates from the cytoplasm to the nucleus. Moreover, we show that a trimeric complex composed of a MIZ-1 recognition DNA element, MIZ-1 and EBNA3A can be formed, and that interaction of MIZ-1 with nucleophosmin (NPM), one of its coactivator, is prevented by EBNA3A. Finally, we show that, in the presence of EBNA3A, expression of the MIZ-1 target gene, CDKN2B, is downregulated and repressive H3K27 marks are established on its promoter region suggesting that EBNA3A directly counteracts the growth inhibitory action of MIZ-1
Scale separation in granular packings: stress plateaus and fluctuations
It is demonstrated, by numerical simulations of a 2D assembly of polydisperse
disks, that there exists a range (plateau) of coarse graining scales for which
the stress tensor field in a granular solid is nearly resolution independent,
thereby enabling an `objective' definition of this field. Expectedly, it is not
the mere size of the the system but the (related) magnitudes of the gradients
that determine the widths of the plateaus. Ensemble averaging (even over
`small' ensembles) extends the widths of the plateaus to sub-particle scales.
The fluctuations within the ensemble are studied as well. Both the response to
homogeneous forcing and to an external compressive localized load (and gravity)
are studied. Implications to small solid systems and constitutive relations are
briefly discussed.Comment: 4 pages, 4 figures, RevTeX 4, Minor corrections to match the
published versio
Gestion du réseau hydropluviométrique de la Guadeloupe : les ressources en eau de surface de la Basse-Terre : année 1990
Relaxation kinetics in two-dimensional structures
We have studied the approach to equilibrium of islands and pores in two
dimensions. The two-regime scenario observed when islands evolve according to a
set of particular rules, namely relaxation by steps at low temperature and
smooth at high temperature, is generalized to a wide class of kinetic models
and the two kinds of structures. Scaling laws for equilibration times are
analytically derived and confirmed by kinetic Monte Carlo simulations.Comment: 6 pages, 7 figures, 1 tabl
Low temperature shape relaxation of 2-d islands by edge diffusion
We present a precise microscopic description of the limiting step for low
temperature shape relaxation of two dimensional islands in which activated
diffusion of particles along the boundary is the only mechanism of transport
allowed. In particular, we are able to explain why the system is driven
irreversibly towards equilibrium. Based on this description, we present a
scheme for calculating the duration of the limiting step at each stage of the
relaxation process. Finally, we calculate numerically the total relaxation time
as predicted by our results and compare it with simulations of the relaxation
process.Comment: 11 pages, 5 figures, to appear in Phys. Rev.
A knowledge-based view of the extending enterprise for enhancing a collaborative innovation advantage
In animal societies as well as in human crowds, many observed collective
behaviours result from self-organized processes based on local interactions
among individuals. However, models of crowd dynamics are still lacking a
systematic individual-level experimental verification, and the local mechanisms
underlying the formation of collective patterns are not yet known in detail. We
have conducted a set of well-controlled experiments with pedestrians performing
simple avoidance tasks in order to determine the laws ruling their behaviour
during interactions. The analysis of the large trajectory dataset was used to
compute a behavioural map that describes the average change of the direction
and speed of a pedestrian for various interaction distances and angles. The
experimental results reveal features of the decision process when pedestrians
choose the side on which they evade, and show a side preference that is
amplified by mutual interactions. The predictions of a binary interaction model
based on the above findings were then compared to bidirectional flows of people
recorded in a crowded street. Simulations generate two asymmetric lanes with
opposite directions of motion, in quantitative agreement with our empirical
observations. The knowledge of pedestrian behavioural laws is an important step
ahead in the understanding of the underlying dynamics of crowd behaviour and
allows for reliable predictions of collective pedestrian movements under
natural conditions
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