Identifying and improving deficient business processes to prepare SMEs for ERP implementation

The study reported in this paper aims to identify, explore and improve hitherto deficient business processes for SMEs in order to prepare them for ERP implementation projects. When business process improvement is traditionally perceived as a task that is particularly related to the ERP project phase, this paper argues that broad changes of business processes should actually be performed well before implementing the system. The research took a Cypriot SME as a case study, and adopted in-depth interview as the main method of data collection. The qualitative data collected was analysed by using an inductive thematic analysis approach. The findings identified that business deficiencies and problems, which can impact potential ERP adoption and usage in SMEs, can be localised across business processes, e.g. sales ordering and stock controlling processes. Disregarding these deficient business processes and business drawbacks in the ERP preparation stage will have implications not just for the subsequent ERP project, but also for the long-term ERP usage

Towards a combined Rotational-Differential Cryptanalytic Framework

In this report, we suggest a new cryptanalytic framework of constructing distinguishers which can be eventually extended to full attacks in the related-key scenario. We name this new paradigm as ”Relational Cryptanalysis”. The main idea is to exhibit the non-randomness of a given encryption algorithm by observing the propagation of specific sets of plaintexts of the form (P,P′) such that these pairs satisfy some rotational and differential properties of the form R1(P) = P′ and P ⊕ P′ ∈ ∆P, for some rotational symmetry R1 and fixed set of differences ∆P . Except of rotational and differential properties, we can add any other relation which seems to hold for a reduced number of rounds of the cryptographic primitive we study. Intuitively, we expect that by adding more relations we increase the observed probability of the propagation and this result to stronger statistical distinguishers

Towards ERP success in SMEs through business process review prior to implementation

Purpose – ERP systems are not the exclusive concern of large companies anymore. More and more small and medium sized enterprises (SMEs) are now engaging with the implementation and exploitation of this type of system. However, reports of ERP failure are numerous and frequent. Very often, this failure results from technical and implementation problems. But even more frequently, it is due to lack of preparation, by the companies themselves, for the implementation process. The purpose of the study reported in this paper was to identify and explore ways in which SMEs may need to prepare themselves before implementing ERP systems. Design/methodology/approach – The research took a Cypriot SME as a case study and adopted an inductive approach supported by in-depth interviews as the main method of data collection. The qualitative data collected were analysed by using a thematic analysis approach. Subsequently, a rich picture and concept maps were used to represent the findings generated. Findings – The study identified that business deficiencies and problems, which can impact potential ERP adoption and usage in SMEs, can be localised across business processes boundaries, such as sales order processing, stock control, and bill of materials management, etc. These business problems were found to be attributed to a variety of organisational, technical and human-related reasons. Therefore, this study established that in order to implement ERPs successfully, organisations may require changes in people's work practices and understanding of technology, ownership and control of business processes, as well as organisational wide policies. Research limitations/implications – This study contributes to the knowledge of ERP preparation and business process improvement in SMEs. Practical implications – The findings of the paper provide useful insights for both academic and practitioners who are thinking of implementing ERP systems. The paper contributes to the body of literature on issues that SMEs may need to reflect upon before embarking in a costly and resource intensive process of ERP implementation. Originality/value – Business process improvement is traditionally considered as the result of an ERP project phase. This is how the large majority of the academic literature and the totality of marketing information by ERP vendors portray it. In fact, the reality of practice shows a different scenario with frequent reports of failure and inadequate ERP implementation. This paper aims at breaking with this myth, by proposing that ERPs cannot resolve the large variety of deficient business processes and internal problems that may exist in SMEs. Therefore, this study argues that SMEs need to prepare in advance by engaging in business process reviews prior to the ERP implementation that is engaging in a pre-implementation or preparation phase

Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms

Exposure of bone-marrow-derived dendritic cells (BMDC) to high-dose ultrapure lipopolysaccharide for 24 hr (LPS-primed BMDC) enhances their potency in preventing inter-photoreceptor retinoid binding protein: complete Freund's adjuvant-induced experimental autoimmune uveoretinitis (EAU). LPS-primed BMDC are refractory to further exposure to LPS (= endotoxin tolerance), evidenced here by decreased phosphorylation of TANK-binding kinase 1, interferon regulatory factor 3 (IRF3), c-Jun N-terminal kinase and p38 mitogen-activated protein kinase as well as impaired nuclear translocation of nuclear factor κB (NF-κB) and IRF3, resulting in reduced tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-12 and interferon-β secretion. LPS-primed BMDC also show reduced surface expression of Toll-like receptor-4 and up-regulation of CD14, followed by increased apoptosis, mediated via nuclear factor of activated T cells (NFATc)-2 signalling. LPS-primed BMDC are not only homotolerant to LPS but are heterotolerant to alternative pathogen-associated molecular pattern ligands, such as mycobacterial protein extract (Mycobacterium tuberculosis). Specifically, while M. tuberculosis protein extract induces secretion of IL-1β, TNF-α and IL-6 in unprimed BMDC, LPS-primed BMDC fail to secrete these cytokines in response to M. tuberculosis. We propose that LPS priming of BMDC, by exposure to high doses of LPS for 24 hr, stabilizes their tolerogenicity rather than promoting immunogenicity, and does so by multiple mechanisms, namely (i) generation of tolerogenic apoptotic BMDC through CD14:NFATc signalling; (ii) reduction of NF-κB and IRF3 signalling and downstream pro-inflammatory cytokine production; and (iii) blockade of inflammasome activation

An assessment of the Literature on Cause-Related Marketing: Implications for International Competitiveness and Marketing Research

Purpose: A substantial, albeit scattered, body of research evidence is accumulating in the cause-related marketing (CRM) research stream. Thus, there is a need of a systematic overview of extant literature to map and holistically understand the CRM domain. Design/methodology/approach: To address this issue and make progress in this important area, the authors systematically review and critically examine the state of academic research on CRM. Findings: Based on a systematic review of 105 journal articles published over the past 30 years, the results reveal that CRM research is a vibrant and rapidly growing domain in the broader marketing field. This assessment exercise also shows that the current state of knowledge about CRM is characterized by persisting knowledge gaps, conflicting empirical results, theoretical inconsistencies, as well as by the absence of international marketing research on the CRM domain. Originality/value: Therefore, the authors critically evaluate the extant CRM research with the aim of increasing its coherence, quality, scope, impact and international dimension. Based on this evaluation, the authors develop an ambitious research agenda that addresses a number of promising research paths embracing different international perspectives. Finally, the authors discuss the contributions to the literature and the implications for both academics and practitioners

Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation

Acknowledgements We would like to thank the staff of the animal facility for their support and care for our animals. Funding was provided by the Wellcome Trust (102705) and Medical Research Council (UK) (MR/J004820/1) and a University of Aberdeen Studentship to BK.Peer reviewedPostprintPublisher PD

Reducing Intrathecal Baclofen Related Infections: Service Evaluation and Best Practice Guidelines

Objectives: Intrathecal baclofen (ITB) pumps are an effective treatment for spasticity; however infection rates have been reported in 3–26% of patients in the literature. The multidisciplinary ITB service has been established at The National Hospital for Neurology and Neurosurgery, UCLH, Queen Square, London for over 20 years. Our study was designed to clarify the rate of infection in our ITB patient cohort and secondly, to formulate and implement best practice guidelines and to determine prospectively, whether they effectively reduced infection rates. / Methods: Clinical record review of all patients receiving ITB pre‐intervention; January 2013–May 2015, and following practice changes; June 2016–June 2018. / Results: Four of 118 patients receiving ITB during the first time period (3.4%, annual incidence rate of infection 1.4%) developed an ITB‐related infection (three following ITB pump replacement surgery, one after initial implant). Infections were associated with 4.2% of ITB‐related surgical procedures. Three of four pumps required explantation. Following change in practice (pre‐operative chlorhexidine skin wash and intraoperative vancomycin wash of the fibrous pocket of the replacement site), only one of 160 ITB patients developed infection (pump not explanted) in the second time period (0.6%, annual incidence rate 0.3%). The infection rate related to ITB surgical procedures was 1.1%. In cases of ITB pump replacement, the infection rate was reduced to 3.3% from 17.6%. / Conclusions: This study suggests that a straightforward change in clinical practice may lower infection rates in patients undergoing ITB therapy

Flexible material formulations for 3D printing of ordered porous beds with applications in bioprocess engineering

Background3D printing is revolutioning many industrial sectors and has the potential to enhance also the biotechnology and bioprocessing fields. Here, we propose a new flexible material formulation to 3D print support matrices with complex, perfectly ordered morphology and with tuneable properties to suit a range of applications in bioprocess engineering.FindingsSupports were fabricated using functional monomers as the key ingredients, enabling matrices with bespoke chemistry, such as charged groups, chemical moieties for further functionalization, and hydrophobic/hydrophilic groups. Other ingredients, e.g. crosslinkers and porogens, can be employed to fabricate supports with diverse characteristics of their porous network, providing an opportunity to further regulate the mechanical and mass transfer properties of the supports. Through this approach, we fabricated and demonstrated the operation of Schoen gyroid columns with (I) positive and negative charges for ion exchange chromatography, (II) enzyme bioreactors with immobilized trypsin to catalyse hydrolysis, and (III) bacterial biofilm bioreactors for fuel desulphurization.ConclusionsThis study demonstrates a simple, cost-effective, and flexible fabrication of customized 3D printed supports for different biotechnology and bioengineering applications