158 research outputs found

    Learning Power from the Margins: Analyzing Action and Reflection in a Social Movement

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    In this paper, I apply the notion of praxis, the dynamic interaction of action and reflection needed for social change, to empirical analysis of a defining moment in the Chilean women’s movement

    Formative, Restorative and Transformative Learning: Insights into the Critical Consciousness of Social Activists

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    Based on our research with diverse social activists in North and South America, we explore the central importance of critical consciousness and how it develops. We analyze the formation, restoration and transformation of critical consciousness in social activists and discuss implications for adult education

    Disrupting the Hegemony of Choice: Community Service Learning in Activist Placements

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    In this paper, we share insights from a research project that investigated the effects of a service learning experience in a graduate adult education seminar with an explicitly critical pedagogical focus and activist placements. We analyze a subset of the findings related to the lack of “choice” through a critique of CSL as a market commodity and argue that disrupting the hegemony of choice had implications for reconstructing student identities

    Glycan analysis as biomarkers for testicular cancer

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    The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main reason is that two of the most important TC biomarkers, ?-fetoprotein (AFP) and human chorionic gonadotropin (hCG), are not produced solely due to TC. Moreover, up to 40% of patients with TC do not have elevated serological biomarkers, which is why serial imaging with CT is the chief means of monitoring progress. On the other hand, exposure to radiation can lead to an increased risk of secondary malignancies. This review provides the first comprehensive account of the applicability of protein glycoprofiling as a promising biomarker for TC with applications in disease diagnostics, monitoring and recurrence evaluation. The review first deals with the description and classification of TC. Secondly, the limitations of current TC biomarkers such as hCG, AFP and lactate dehydrogenase are provided together with an extensive overview of the glycosylation of hCG and AFP related to TC. The final part of the review summarises the potential of glycan changes on either hCG and AFP as TC biomarkers for diagnostics and prognostics purposes, and for disease recurrence evaluation. Finally, an analysis of glycans in serum and tissues as TC biomarkers is also provided. - 2019 by the authors.Funding: The authors wish to acknowledge the financial support received from the Slovak Research and Development Agency APVV 17-0300. This work was supported by the Ministry of Health of the Slovak Republic under project registration no. 2018/23-SAV-1. P.K. expresses thanks that this work was also made possible by NPRP grants NPRP 6-381-1-078 and NPRP-9-219-2-105 from the Qatar National Research Fund (A Member of The Qatar Foundation). The findings achieved herein are solely the responsibility of the authors.Scopu

    A representation theorem for MV-algebras

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    An {\em MV-pair} is a pair (B,G)(B,G) where BB is a Boolean algebra and GG is a subgroup of the automorphism group of BB satisfying certain conditions. Let G\sim_G be the equivalence relation on BB naturally associated with GG. We prove that for every MV-pair (B,G)(B,G), the effect algebra B/GB/\sim_G is an MV- effect algebra. Moreover, for every MV-effect algebra MM there is an MV-pair (B,G)(B,G) such that MM is isomorphic to B/GB/\sim_G

    Efficiency of Sanitary Treatment in Poultry Breeding and Poultry Meat Processing Plant

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    The aim of this study was to observe the effectiveness of disinfection on a broiler farm and in a plant processing the poultry from this farm. The broiler farm was disinfected with a preparation based on peracetic acid while a preparation based on quarternary ammonium salt was used in the processing plant. We evaluated swabs taken from surfaces, which come into contact with broilers and broiler meat. Results of the swabs taken by standard microbiological swabbing method were evaluated with results of the swabs taken by the ATP-bioluminescence method. The microbiological examination included total counts of microorganisms, coliform count and moulds. When using the standard plate counts method on the broiler farm we found that the plate counts in 0% of swabs were 100 CFU. In the processing plant, out of 22% of swabs 100. The bioluminescence method was applied only in the processing plant where 300 RLU were measured in 80, 10 and 10% of swabs, resp. Our observations and results allowed us to conclude that the disinfectants tested appeared suitable for the respective premises and the ATP bioluminescence method could be use as a as a suitable complement for detection of cleanliness of individual surfaces

    Mgm101: A double-duty Rad52-like protein

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    Mgm101 has well-characterized activity for the repair and replication of the mitochondrial genome. Recent work has demonstrated a further role for Mgm101 in nuclear DNA metabolism, contributing to an S-phase specific DNA interstrand cross-link repair pathway that acts redundantly with a pathway controlled by Pso2 exonuclease. Due to involvement of FANCM, FANCJ and FANCP homologues (Mph1, Chl1 and Slx4), this pathway has been described as a Fanconi anemia-like pathway. In this pathway, Mgm101 physically interacts with the DNA helicase Mph1 and the MutSα (Msh2/Msh6) heterodimer, but its precise role is yet to be elucidated. Data presented here suggests that Mgm101 functionally overlaps with Rad52, supporting previous suggestions that, based on protein structure and biochemical properties, Mgm101 and Rad52 belong to a family of proteins with similar function. In addition, our data shows that this overlap extends to the function of both proteins at telomeres, where Mgm101 is required for telomere elongation during chromosome replication in rad52 defective cells. We hypothesize that Mgm101 could, in Rad52-like manner, preferentially bind single-stranded DNAs (such as at stalled replication forks, broken chromosomes and natural chromosome ends), stabilize them and mediate single-strand annealing-like homologous recombination event to prevent them from converting into toxic structures

    Sharp and fuzzy observables on effect algebras

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    Observables on effect algebras and their fuzzy versions obtained by means of confidence measures (Markov kernels) are studied. It is shown that, on effect algebras with the (E)-property, given an observable and a confidence measure, there exists a fuzzy version of the observable. Ordering of observables according to their fuzzy properties is introduced, and some minimality conditions with respect to this ordering are found. Applications of some results of classical theory of experiments are considered.Comment: 23 page
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