Effect of Damping on the Natural Frequencies of Linear Dynamic Systems

An analysis is presented of the effect of weak damping on the natural frequencies of linear dynamic systems. It is shown that the highest natural frequency is always decreased by damping, but the lower natural frequencies may either increase or decrease, depending on the form of the damping matrix

The Influence of Swirl Brakes and a Tip Discharge Orifice on the Rotordynamic Forces Generated by Discharge-to-Suction Leakage Flows in Shrouded Centrifugal Pumps

This paper reports on experiments conducted in the Rotor Force Test Facility at the California Institute of Technology to examine the effects of a tip leakage restriction and swirl brakes on the rotordynamic forces due to leakage flows on an impeller undergoing a prescribed circular whirl. The experiments simulate the leakage flow conditions and geometry of the Alternate Turbopump Design (ATD) of the Space Shuttle High Pressure Oxygen Turbopump and are critical to evaluating the pump's instability problems. Results indicate the detrimental effects of a discharge orifice and the beneficial effects of adding swirl brakes. Plots of the tangential and normal forces versus whirl frequency ratio show a substantial increase in these forces along with destabilizing resonances when a discharge orifice is added. When swirl brakes are added, some of the detrimental effects of the orifice are reduced. For the tangential force, a significant reduction occurs and a destabilizing resonance appears to be eliminated. For the normal force, although the overall force is not reduced, once again a destabilizing resonance appears to be eliminated

The Influence of Swirl Brakes on the Rotordynamic Forces Generated by Discharge-to-Suction Leakage Flows in Centrifugal Pumps

Increasing interest has been give to swirl brakes as a means of reducing destabilizing rotordynamic forces due to leakage flows in new high speed rocket turbopumps. Although swirl brakes have been used successfully in practice (such as with the Space Shuttle HPOTP), no experimental test until now have been performed to demonstrate their beneficial effect over a range of leakage flow rates. The present study investigates the effect of swirl brakes on rotordynamic forces generated by discharge-to-suction leakage flows in the annulus of shrouded centrifugal pumps over a range of subsynchronous whirl ratios and various leakage flow rates. In addition, the effectiveness of swirl brakes in the presence of leakage inlet (pump discharge) swirl is also demonstrated. The experimental data demonstrates that with the addition of swirl brakes a significant reduction in the destabilizing tangential force for lower flow rates is achieved. At higher flow rates, the brakes are detrimental. In the presence of leakage inlet swirl, brakes were effective over all leakage flow rates tested in reducing the range of whirl frequency ratio for which the tangential force is destabilizing

A brief description of the Jameson-Caughey NYU transonic swept-wing computer program: FLO 22

A computer program for analyzing inviscid, isentropic, transonic flow past 3-D swept configurations is presented. Some basic aspects of the program are: (1) the free-stream Mach number is restricted only by the isentropic assumption; (2) weak shock waves are automatically located wherever they occur in the flow; (3) the finite-difference form of the full equation for the velocity potential is solved by the method of relaxation, after the flow exterior to the airfoil is mapped to the upper half plane; (4) the mapping procedure allows exact satisfaction of the boundary conditions and use of supersonic free stream velocities; (5) the finite difference operator is locally rotated in supersonic flow regions so as to properly account for the domain of dependence; and (6) the relaxation algorithm was stabilized using criteria from a time-like analogy

Laser Velocimeter Measurements in the Leakage Annulus of a Whirling Shrouded Centrifugal Pump

Previous experiments conducted in the Rotor Force Test Facility at the California Institute of Technology have thoroughly examined the effect of leakage flows on the rotordynamic forces on a centrifugal pump impeller undergoing a prescribed circular whirl. These leakage flows have been shown to contribute substantially to the total fluid induced forces acting on a pump. However, to date nothing is known of the flow field in the leakage annulus of shrouded centrifugal pumps. No attempt has been made to qualitatively or quantitatively examine the velocity field in the leakage annulus. Hence the test objective of this experiment is to acquire fluid velocity data for a geometry representative of the leakage annulus of a shrouded centrifugal pump while the rotor is whirling using laser velocimetry. Tests are performed over a range of whirl ratios and a flowrate typical of Space Shuttle Turbopump designs. In addition to a qualitive study of the flow field, the velocity data can be used to anchor flow models

Measuring perinatal complications: methodologic issues related to gestational age

<p>Abstract</p> <p>Background</p> <p>Perinatal outcomes differ by week of gestational age. However, it appears that how measures to examine these outcomes vary among various studies. The current paper explores how perinatal complications are reported and how they might differ when different denominators, numerators, and comparison groups are utilized.</p> <p>Conclusion</p> <p>One issue that can clearly affect absolute rates and trends is how groups of women are categorized by their gestational age. Since most perinatal outcomes can only occur in women and neonates who have delivered, using the number of pregnancies delivered (PD) as the denominator of outcomes is appropriate. However, for an outcome such as antepartum stillbirth, all women who are pregnant at a particular gestational age are at risk. Thus, the denominator should include all ongoing pregnancies (OP). When gestational age is used by week this means using both deliveries during a particular week plus those women who deliver beyond the particular week of gestation in the denominator. Researchers should be careful to make sure they are utilizing the appropriate measure of perinatal complications so they do not report findings that would be misleading to clinicians, patients, and policy makers.</p

Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure

The accumulation of the scrapie agent in lymphoid tissues following inoculation via the skin is critical for efficient neuroinvasion, but how the agent is initially transported from the skin to the draining lymph node is not known. Langerhans cells (LCs) are specialized antigen-presenting cells that continually sample their microenvironment within the epidermis and transport captured antigens to draining lymph nodes. We considered LCs probable candidates to acquire and transport the scrapie agent after inoculation via the skin. XS106 cells are dendritic cells (DCs) isolated from mouse epidermis with characteristics of mature LC cells. To investigate the potential interaction of LCs with the scrapie agent XS106 cells were exposed to the scrapie agent in vitro. We show that XS106 cells rapidly acquire the scrapie agent following in vitro exposure. In addition, XS106 cells partially degrade the scrapie agent following extended cultivation. These data suggest that LCs might acquire and degrade the scrapie agent after inoculation via the skin, but data from additional experiments demonstrate that this ability could be lost in the presence of lipopolysaccharide or other immunostimulatory molecules. Our studies also imply that LCs would not undergo maturation following uptake of the scrapie agent in the skin, as the expression of surface antigens associated with LC maturation were unaltered following exposure. In conclusion, although LCs or DCs have the potential to acquire the scrapie agent within the epidermis our data suggest it is unlikely that they become activated and stimulated to transport the agent to the draining lymph node

Responding to the Challenges of Gifted Education in Rural Communities

There are both achievement and opportunity gaps for low-income students when compared to their economically advantaged peers; and, for rural students, these gaps may be even more pronounced. In this manuscript we draw from our ongoing work in a five-year federally-funded, Jacob K. Javits grant focusing on promoting gifted education in rural schools. To address issues of under-identification of gifted students in these settings, and to investigate ways to maximize achievement, we established an alternative process for identifying gifted students in rural schools; and we created units integrating place-based pedagogy within an evidence-based curriculum model as an intervention. Finally, we discuss preliminary findings from the pilot year and first half of the second year of the study documenting success in augmenting the pool of identified students and engaging teachers in implementing the curriculum. Perhaps more importantly, we document lessons learned and more global takeaways for the field. Specifically, we discuss the influence of deficit thinking with regard to rural schooling (and subsequent recognition of gifts and talents), the risk of generalizing rural to all rural places, and the nuances of rural poverty not captured in commonly used metrics, such as Free and Reduced Lunch

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc).

Prion diseases, also known as transmissible spongiform encephalopathies, are a group of fatal neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans. The 'protein only hypothesis' advocates that PrP(Sc), an abnormal isoform of the cellular protein PrP(C), is the main and possibly sole component of prion infectious agents. Currently, no effective therapy exists for these diseases at the symptomatic phase for either humans or animals, though a number of compounds have demonstrated the ability to eliminate PrPSc in cell culture models. Of particular interest are synthetic polymers known as dendrimers which possess the unique ability to eliminate PrP(Sc) in both an intracellular and in vitro setting. The efficacy and mode of action of the novel anti-prion dendrimer mPPIg5 was investigated through the creation of a number of innovative bio-assays based upon the scrapie cell assay. These assays were used to demonstrate that mPPIg5 is a highly effective anti-prion drug which acts, at least in part, through the inhibition of PrP(C) to PrP(Sc) conversion. Understanding how a drug works is a vital component in maximising its performance. By establishing the efficacy and method of action of mPPIg5, this study will help determine which drugs are most likely to enhance this effect and also aid the design of dendrimers with anti-prion capabilities for the future