Una lettera di frate Aicardo da Camodeia, arcivescovo di Milano (28 giugno 1319)

Lo scopo di questo contributo \ue8 di fornire l\u2019edizione critica e di analizzare una lettera patente spedita da Avignone dall\u2019arcivescovo di Milano Aicardo da Camodeia al suo vicario Obizzone da Momo. La missiva \ue8 datata 28 giugno 1319 ed \ue8 conservata presso la Biblioteca Civica Berio di Genova.The aim of this paper is to give a crital edition and to study a litterae patentes sent from Avignon by Aicardo of Camodeia, archibishop of Milan, to Obizzone of Momo, archibishop\u2019s vicar. This missive is dated on 28th of June 1319 and it is kept at Berio Library in Genoa

I conti in tasca ai notai. Ricerche sul notariato ligure: Genova e Savona (1154-1225)

Le due principali citta\u300 della Liguria, Genova e Savona, grazie a una situazione conservativa particolarmente fortunata per antichita\u300 e consistenza del materiale, costituiscono un eccezio- nale punto di partenza per cercare di stabilire il reddito effettivo di un notaio nel medioevo. La ricerca e\u300 stata condotta su frammenti di registri, editi e inediti, appartenenti a 24 professionisti a partire dal piu\u300 antico pervenuto (il cartolare di Giovanni scriba del 1154) sino ad arrivare al primo quarto del secolo XIII. Attraverso la rilevazione delle indicazioni relative ai compensi delle diverse tipologie contrattuali si e\u300 ricostruita una bozza del tariffario allora esistente. Sulla base di questa bozza e\u300 stato possibile calcolare approssimativamente il ricavo annuale e quindi rapportarlo con il \u201ccosto della vita\u201d in quegli anni in modo da valutare l\u2019effettivo stato economico di questa categoria professionale, le eventuali modalita\u300 di investimento delle somme ricavate dall\u2019attivita\u300 notarile e la collocazione sociale del notariato.Thanks to a particularly fortunate situation in terms of documentary preservation (as concerns both the antiquity and the amount of available material), Liguria\u2019s two chief cities, Genoa and Savona, are an exceptional starting point for an attempt at establishing the actual income of a medieval notary. The research has been conducted on the fragments, both edited and unpublished, of registers belonging to 24 notaries, beginning from the oldest surviving cartulary (of Giovanni scriba, 1154) up to those dating from the first quarter of the thirteenth century. By collecting references to fees paid for different types of contracts it has been possible to reconstruct a draft of a \u201cprice list\u201d. This draft has been used as a basis to calculate an approximate income. A comparison of this data with the \u201ccost of living\u201d during this period allows to evaluate the economic status of this professional category, the way notaries invested their incomes, and their social statu

Il Centro studi interateneo Notariorum itinera

Il Centro studi interateneo Notariorum Itinera con sede amministrativa presso l\u2019Universit\ue0 degli Studi di Genova e sedi consorziate le Universit\ue0 degli Studi di Bari, Bologna, Catanzaro, Milano Statale, Pavia, Roma Tor vergata, Salerno e Torino \ue8 stato formalmente costituito nel maggio 2017. L\u2019obiettivo \ue8 quello di studiare il notariato, i registri notarili italiani ed europei e, pi\uf9 in generale, tutte le fonti a essi collegate per addivenire a una conoscenza a tutto tondo 12 senza limiti cronologici e geografici 12 dell\u2019attivit\ue0 di questa figura professionale. Il contributo propone una breve analisi dello status questionis e illustra i primi risultati delle indagini in corso.Centro studi interateneo Notariorum Itinera \u2013 headquarter at the University of Genoa and subsidiaries at the Universities of Bari, Bologna, Catanzaro, Milan Statale, Pavia, Rome Tor vergata, Salerno and Turin \u2013 was formally established in May 2017. The aim of Centro studi is to study notary, Italian and european notarial registers and, more widely, all the related records in order to get a full knowledge \u2013 without chronological and geographical limits \u2013 of the activity of this professional category. The paper focuses on the status questionis and illustrates the first results of ongoing studies

Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases

Abstract The Wnt/β-catenin signaling is a conserved pathway that has a crucial role in embryonic and adult life. Dysregulation of the Wnt/β-catenin pathway has been associated with diseases including cancer, and components of the signaling have been proposed as innovative therapeutic targets, mainly for cancer therapy. The attention of the worldwide researchers paid to this issue is increasing, also in view of the therapeutic potential of these agents in diseases, such as Parkinson's disease (PD), for which no cure is existing today. Much evidence indicates that abnormal Wnt/β-catenin signaling is involved in tumor immunology and the targeting of Wnt/β-catenin pathway has been also proposed as an attractive strategy to potentiate cancer immunotherapy. During the last decade, several products, including naturally occurring dietary agents as well as a wide variety of products from plant sources, including curcunim, quercetin, berberin, and ginsenosides, have been identified as potent modulators of the Wnt/β-catenin signaling and have gained interest as promising candidates for the development of chemopreventive or therapeutic drugs for cancer. In this review we make an overview of the nature-derived compounds reported to have antitumor activity by modulating the Wnt/β-catenin signaling, also focusing on extraction methods, chemical features, and bio-activity assays used for the screening of these compounds

An enzymatic flow-based preparative route to vidarabine

The bi-enzymatic synthesis of the antiviral drug vidarabine (arabinosyladenine, ara-A), catalyzed by uridine phosphorylase from Clostridium perfringens (CpUP) and a purine nucleoside phosphorylase fromAeromonas hydrophila (AhPNP), was re-designed under continuous-flow conditions. Glyoxyl-agarose and EziGTM1 (Opal) were used as immobilization carriers for carrying out this preparative biotransformation. Upon setting-up reaction parameters (substrate concentration and molar ratio, temperature, pressure, residence time), 1 g of vidarabine was obtained in 55% isolated yield and >99% purity by simply running the flow reactor for 1 week and then collecting (by filtration) the nucleoside precipitated out of the exiting flow. Taking into account the substrate specificity of CpUP and AhPNP, the results obtained pave the way to the use of the CpUP/AhPNP-based bioreactor for the preparation of other purine nucleosides