58 research outputs found

    Power couplers for Spiral 2

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    http://accelconf.web.cern.ch/AccelConf/SRF2011/papers/frioa04.pdf Due to its success, we intend to have a PRST-AB SRF2011 special edition.International audienc

    Human plague: An old scourge that needs new answers

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    Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outbreaks, and deadly global epidemics among humans. Between September and November 2017, an outbreak of urban pneumonic plague was declared in Madagascar, which refocused the attention of the scientific community on this ancient human scourge. Given recent trends and plague’s resilience to control in the wild, its high fatality rate in humans without early treatment, and its capacity to disrupt social and healthcare systems, human plague should be considered as a neglected threat. A workshop was held in Paris in July 2018 to review current knowledge about plague and to identify the scientific research priorities to eradicate plague as a human threat. It was concluded that an urgent commitment is needed to develop and fund a strong research agenda aiming to fill the current knowledge gaps structured around 4 main axes: (i) an improved understanding of the ecological interactions among the reservoir, vector, pathogen, and environment; (ii) human and societal responses; (iii) improved diagnostic tools and case management; and (iv) vaccine development. These axes should be cross-cutting, translational, and focused on delivering context-specific strategies. Results of this research should feed a global control and prevention strategy within a “One Health” approach

    Last Spiral 2 couplers preparation and RF conditioning

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    THP054International audienc

    Multipurpose applications of the accelerator-based neutron source GENEPI2

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    International audienceGENEPI2 (GEnérateur de NEutrons Pulsé Intense) is anaccelerator-based neutron source operating at LPSC laboratory in Grenoble(France). The neutrons are produced at 2.5MeV or 14.2MeV trough fusion reactions.GENEPI2 specifications allow performing efficiently accelerated irradiationtests of integrated circuits. This facility can also be operated to test and calibrate differenttypes of detectors. This paper will describe the facility and its performances.Then, measurements of the neutron production will be presented as well as differenttypes of experiments and irradiations. Finally, we describe upgrades undertaken toincrease the neutron flux and optimize the facility for multiple applications

    Prevalence of articular chondrocalcinosis in elderly subjects in a rural area of Catalonia.

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    OBJECTIVES--To undertake an epidemiological survey of the prevalence of radiological chondrocalcinosis in the elderly population of Osona, a rural area of Catalonia, north east Spain. METHODS--Knee and wrist radiographs were performed on 261 subjects (141 women, 120 men) aged at least 60 years, who attended a series of 35 general practitioners for various medical problems. RESULTS--Twenty seven subjects had articular chondrocalcinosis, which represents a crude prevalence of 10%. Articular chondrocalcinosis was more often observed in women than in men (14 v 6%). Articular chondrocalcinosis increases in occurrence with age, rising from 7% in subjects aged 60-69 years to 43% in subjects older than 80 years. A similar occurrence of articular chondrocalcinosis was noted in the indigenous population, in which several cases of familial chondrocalcinosis have previously been reported, and in subjects born in other areas of Spain. All but one subject with articular chondrocalcinosis had chondrocalcinosis of the knee. The occurrence of rheumatic disorders did not differ significantly between subjects with articular chondrocalcinosis and those without. CONCLUSIONS--Articular chondrocalcinosis is an age related disorder, which could partly explain the discrepancies in its prevalence reported in previous studies. In most subjects with articular chondrocalcinosis recruited from an unselected population the clinical manifestations are probably mild or even absent

    The low energy beam transport line for the MYRRHA accelerator

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    International audienceThe MYRRHA Project aims at the construction of a new research reactor in Mol (Belgium) todemonstrate the transmutation feasibility with an accelerator-driven system (ADS). In its subcriticalconfiguration, the MYRRHA facility requires a proton flux with a maximum power of 2.4 MW(600 MeV – 4 mA). Such a continuous wave (CW) beam will be delivered by a superconducting linearaccelerator (linac) which must fulfil very stringent reliability requirements to ensure the safe ADSoperation with a high level of availability. The proton beam will be injected in the superconductinglinac with an energy of 17 MeV. The injector will enable to condition and pre-accelerate the protonbeam from 30 keV to 17 MeV. The injector is composed of: the proton source, the low-energy beamtransport line (LEBT), the Radio-frequency quadrupole (RFQ), and a series of CH-DTL cavities. Due tothe very-high reliability requirements it is absolutely necessary to carry out prototyping of all theelements of the accelerator in order to optimise its operation. In this purpose a LEBT prototype hasbeen built and is presently installed and operated at LPSC Grenoble (France). An experimentalprogramme to optimise the tuning of the line, the beam transport and to study the space-chargecompensation mechanism, is in progress. Once the line is commissioned it will be moved to Louvainla-Neuve (Belgium) to be coupled with the RFQ. We here review the construction and thecommissioning of the LEBT. Some experimental results are discussed, in particular the observedspace-charge compensation effects
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