32,119 research outputs found
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The relationship of drug reimbursement with the price and the quality of pharmaceutical innovations
This paper studies the strategic interaction between pharmaceutical firms' pricing decisions and government agencies' reimbursement decisions which discriminate between patients by giving reimbursement rights to patients for whom the drug is most effective. We show that if the reimbursement decision preceeds the pricing decision, the agency only reimburses some patients if the private and public health benefits from the new drug diverge. That is, when (i) there are large externalities of consuming the drug and (ii) the difference in costs between the new drug and the alternative treatment is large. Alternatively, if the firm can commit to a price in advance of the reimbursement decision, we identify a strategic effect which implies that by committing to a high price ex ante, the firm can force a listing outcome and make the agency more willing to reimburse than in the absence of commitment
Encoding algebraic power series
Algebraic power series are formal power series which satisfy a univariate
polynomial equation over the polynomial ring in n variables. This relation
determines the series only up to conjugacy. Via the Artin-Mazur theorem and the
implicit function theorem it is possible to describe algebraic series
completely by a vector of polynomials in n+p variables. This vector will be the
code of the series. In the paper, it is then shown how to manipulate algebraic
series through their code. In particular, the Weierstrass division and the
Grauert-Hironaka-Galligo division will be performed on the level of codes, thus
providing a finite algorithm to compute the quotients and the remainder of the
division.Comment: 35 page
Studies of the nucler equation of state using numerical calculations of nuclear drop collisions
A numerical calculation for the full thermal dynamics of colliding nuclei was developed. Preliminary results are reported for the thermal fluid dynamics in such processes as Coulomb scattering, fusion, fusion-fission, bulk oscillations, compression with heating, and collisions of heated nuclei
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Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy. NAFLD covers a spectrum that ranges from simple steatosis, nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis, to cirrhosis, which is a major risk factor for hepatocellular carcinoma. Lifestyle and eating habit changes during the last century have made NAFLD the most common liver disease linked to obesity, type 2 diabetes mellitus and dyslipidemia, with a global prevalence of 25%. NAFLD arises when the uptake of fatty acids (FA) and triglycerides (TG) from circulation and de novo lipogenesis saturate the rate of FA β-oxidation and very-low density lipoprotein (VLDL)-TG export. Deranged lipid metabolism is also associated with NAFLD progression from steatosis to NASH, and therefore, alterations in liver and serum lipidomic signatures are good indicators of the disease's development and progression. This review focuses on the importance of the classification of NAFLD patients into different subtypes, corresponding to the main alteration(s) in the major pathways that regulate FA homeostasis leading, in each case, to the initiation and progression of NASH. This concept also supports the targeted intervention as a key approach to maximize therapeutic efficacy and opens the door to the development of precise NASH treatments
Quantum control of the motional states of trapped ions through fast switching of trapping potentials
We propose a new scheme for supplying voltages to the electrodes of
microfabricated ion traps, enabling access to a regime in which changes to the
trapping potential are made on timescales much shorter than the period of the
secular oscillation frequencies of the trapped ions. This opens up
possibilities for speeding up the transport of ions in segmented ion traps and
also provides access to control of multiple ions in a string faster than the
Coulomb interaction between them. We perform a theoretical study of ion
transport using these methods in a surface-electrode trap, characterizing the
precision required for a number of important control parameters. We also
consider the possibilities and limitations for generating motional state
squeezing using these techniques, which could be used as a basis for
investigations of Gaussian-state entanglement.Comment: Accepted by New Journal of Physic
On the Ehrenfest theorem of quantum mechanics
We give a mathematically rigorous derivation of Ehrenfest's equations for the
evolution of position and momentum expectation values, under general and
natural assumptions which include atomic and molecular Hamiltonians with
Coulomb interactions.Comment: To appear in J. Math. Phy
Cell adhesion on ti surface with controlled roughness
In this report, the in situ interaction between Saos-2 osteoblast cells and a smooth Ti surface was examined over time. The adhesion kinetics and mechanisms of cellular proliferation were monitored by quartz crystal microbalance (QCM) and electrochemical impedance spectroscopy (EIS). The rate of Saos-2 attachment on Ti surfaces, obtained from the measurements performed with the QCM, is a first-order reaction, with k=2.103 min1. The impedance measurements indicate that in the absence of cells, the Ti resistance diminishes over time (7 days), due to the presence of amino acids and proteins from the culture medium that have been a dsorbed, while in the presence of osteoblasts, this decrease is much greater because of the compounds generated by the cells that accelerate the dissolution of TiAdhesión de osteoblastos sobre una superficie de Ti de rugosidad controlada. En este trabajo, se ha estudiado la interacción in situ entre células osteoblásticas Saos-2 y una superficie de Ti de rugosidad controlada a lo largo del tiempo. El estudio de la cinética y los mecanismos de proliferación celular de adhesión se ha realizado a través de la microbalanza de cristal de cuarzo (QCM) y espectroscopía de impedancia electroquímica (EIS). La velocidad de adhesión de los osteoblastos sobre la superficie de Ti obtenida a través de medidas con la QCM, sigue una reacción de primer orden, con k=2×10−3 min−1. Los ensayos de impedancia indican que, en ausencia de las células, la resistencia del Ti disminuye con el tiempo (7 días), debido a la presencia de aminoácidosy proteínas del medio de cultivo que se han adsorbido, mientras que en presencia de células, esta disminución es mucho mayor debido a los productos metabólicos generados por las células que aceleran la disolución del TiThe authors thank the financial support under projects MAT 2008-06719-C03-01, CTQ2008-05775/ BQU and by the Comunidad Autónoma de Madrid (CAM) through AVANSENS S2009/PPQ-164
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