Homeless street children in Nepal : use of allostatic load to assess the burden of childhood adversity.

As challenges to child well-being through economic disadvantage, family disruption, and migration or displacement escalate world wide, the need for cross-culturally robust understanding of childhood adversity proportionately increases. Toward this end, developmental risk was assessed in four contrasting groups of 107 Nepali children ages 10–14 years that represent distinctive, common conditions in which contemporary children grow up. Relative cumulative burden (allostatic load) indexed by multiple dimensions of physical and psychosocial stress was ascertained among homeless street boys and three family-based groups, from poor urban squatter settlements, urban middle class, and a remote rural village. Biomarkers of stress and vulnerability to stress included growth status, salivary cortisol, antibodies to Epstein–Barr virus, acute phase inflammatory responses (alpha1-antichymotrypsin), and cardiovascular fitness and reactivity (flex heart rate and pressor response). Individual biomarkers of risk and allostatic load differed markedly among groups, were highest in villagers, and varied by components of allostatic load. Such data suggest a need for critical appraisal of homelessness and migration as a risk factor to youth, given prevailing local conditions such as rural poverty, and represents the only multidimensional study of childhood allostatic load and developmental risk in non-Western settings

Medical applications of nasa-developed science and technology quarterly progress report no. 2, 30 apr. - 31 jul. 1965

Medical applications of aerospace science and technolog

APPLICATION OF A BIO-ECONOMIC-ENGINEERING MODEL FOR SHRIMP MARICULTURE SYSTEMS

Resource /Energy Economics and Policy,

Reply to Comment of Gazdzicki and Heinz on Strangeness Enhancement in p+Ap+A and S+AS+A

The Comment of Gazdzicki and Heinz is flawed because their assumed baryon stopping power in $pA$ is inconsistent with data and because they ignored half the analysis based on the VENUS model. The Comment continues the misleading presentation of strangeness enhancement by focusing on ratios of integrated yields. Those ratios discard essential experimental information on the rapidity dependence of produced $\Lambda$ and obscure discrepancies between different data sets. Our conclusion remains that the NA35 minimum bias data on $p+S\rightarrow\Lambda +X$ indicate an anomalous enhancement of central rapidity strangeness in few nucleon reactions that points to non-equilibrium dynamics as responsible for strangeness enhancement in nuclear reactions.Comment: revtex file, 6 pages, submitted to Phys. Rev.

Collateral and Debt Maturity Choice. A Signaling Model

This paper derives optimal loan policies under asymmetric information where banks offer loan contracts of long and short duration, backed or unbacked with collateral. The main novelty of the paper is that it analyzes a setting in which high quality firms use collateral as a complementary device along with debt maturity to signal their superiority. The least-cost signaling equilibrium depends on the relative costs of the signaling devices, the difference in firm quality and the proportion of good firms in the market. Model simulations suggest a non-monotonic relationship between firm quality and debt maturity, in which high quality firms have both long-term secured debt and short-term secured or non-secured debt.

Sampling Local Fungal Diversity in an Undergraduate Laboratory using DNA Barcoding

Traditional methods for fungal species identification require diagnostic morphological characters and are often limited by the availability of fresh fruiting bodies and local identification resources. DNA barcoding offers an additional method of species identification and is rapidly developing as a critical tool in fungal taxonomy. As an exercise in an undergraduate biology course, we identified 9 specimens collected from the Hendrix College campus in Conway, Arkansas, USA to the genus or species level using morphology. We report that DNA barcoding targeting the internal transcribed spacer (ITS) region supported several of our taxonomic determinations and we were able to contribute 5 ITS sequences to GenBank that were supported by vouchered collection information. We suggest that small-scale barcoding projects are possible and that they have value for documenting fungal diversity

Training-of-Trainers Neuroscience and Mental Health Teacher Education in Liberia Improves Self-Reported Support for Students

Education programs have been central to reestablishing social norms, rebuilding public educational institutions, and addressing public attitudes toward mental illness in Liberia following a protracted civil war and the Ebola epidemic. The aim of this study was to determine if a program combining an understanding of neuroscience with mental health literacy content could increase teachers’ awareness of students’ mental health issues and produce changes in teacher attitudes and classroom practices. A tiered Training-of-Trainers approach was employed. The first workshop trained 24 Liberian secondary science teachers in the neurobiology of learning, memory, emotions, stress and adolescent brain development. A Leadership Team formed from eight of the Tier I participants then adapted the curriculum, added in more mental health literacy content and led four Tier II workshops and four follow-up Refresher sessions. Participants completed a neuroscience knowledge test and surveys assessing stigma, general perceptions of people with mental illness, and burnout. A subset of Tier II teachers participated in a structured interview at the Refresher time point. Teachers in both tiers acquired basic neuroscience knowledge. Tier I, but not Tier II teachers significantly improved their surveyed attitudes toward people with mental illness. No changes were found in overall teacher burnout. Despite these survey results, the interviewed Tier II teachers self-reported behavioral changes in how they approached their teaching and students in their classrooms. Interviewees described how they now understood social and emotional challenges students might be experiencing and recognized abnormal behaviors as having a biopsychosocial basis. Teachers reported reduced use of verbal and corporal punishment and increased positive rewards systems, such as social and emotional support for students through building relationships. Refresher discussions concurred with the interviewees. In contrast to previous teacher mental health literacy programs which did not bring about a change in helping behaviors, this pilot program may have been successful in changing teacher knowledge and self-reported behaviors, improving teacher–student relationships and decreasing harsh discipline. The combination of basic neuroscience concepts with training on how to recognize mental health issues and refer students should be investigated further as a strategy to promote teacher mental health literacy

Psychological strategies to resist slowing down or stopping during endurance activity: An expert opinion paper

Within this paper, we provide an expert opinion on five evidence-based psychological strategies that could help endurance participants overcome slowing down and stopping during performance: goal setting, motivational self-talk, relaxation, distraction, and pacing. We argue that these strategies are well-suited for delivery as brief-contact, educational interventions that could be accessible to large numbers of participants who do not have access to a sport and exercise psychologist. These interventions could be delivered using websites, online videos, workshops, or magazine articles. We propose a novel use for implementation intentions (i.e. if-then planning) to develop endurance participants’ conditional knowledge of when to use specific strategies. In addition, although research evidence suggests that these psychological strategies may be efficacious for overcoming thoughts of slowing down or stopping, there are important limitations in the research evidence. In particular, there is a dearth of ecologically valid, field-based effectiveness studies. Finally, we consider situations where attempts to resist slowing down or stopping during endurance activity may not be advisable. Scenarios include when there is an increased likelihood of injury, or when environmental conditions increase the risk of life-threatening event