Evaluation of detailed aromatic mechanisms (MCMv3 and MCMv3.1) against environmental chamber data

International audienceA high quality dataset on the photo-oxidation of benzene, toluene, p-xylene and 1,3,5-trimethylbenzene has been obtained from experiments in the European Photoreactor (EUPHORE), a large outdoor environmental reaction chamber. The experiments were designed to test sensitive features of detailed aromatic mechanisms, and the dataset has been used to evaluate the performance of the Master Chemical Mechanism Version 3 (MCMv3). An updated version (MCMv3.1) was constructed based on recent experimental data, and details of its development are described in a companion paper. The MCMv3.1 aromatic mechanisms have also been evaluated using the EUPHORE dataset. Significant deficiencies have been identified in the mechanisms, in particular: 1) an over-estimation of the ozone concentration, 2) an under-estimation of the NO oxidation rate, 3) an under-estimation of OH. The use of MCMv3.1 improves the model-measurement agreement in some areas but significant discrepancies remain

Tissue carcinoembryonic antigen and oestrogen receptor status in breast carcinoma: an immunohistochemical study of clinical outcome in a series of 252 patients with long-term follow-up.

Carcinoembryonic antigen (CEA) is a well-known tumour marker whose immunohistochemical expression could be prognostically relevant in breast carcinomas. We evaluated CEA immunohistochemical expression, using the specific T84.66 monoclonal antibody, in a series of 252 consecutive cases of infiltrating breast carcinomas (104 N0, 148 N1/2) with median follow-up of 84 months. Oestrogen receptor (ER) status has been evaluated with the immunohistochemical method (ER1D5 antibody, 10% cut-off value): 121 cases were ER negative, 128 cases were ER positive and in three cases ER status was unknown. CEA staining was cytoplasmic; staining intensity and percentage of reacting cells were combined to obtain a final score (CEA score). The difference between the distribution of CEA score within the modalities of the other variables was not statistically significant. Univariate survival analysis has been performed on the series of node-negative and node-positive patients. In the latter subgroup, this has been performed separately for patients treated with systemic adjuvant hormonal therapy or chemotherapy. A multivariate analysis was only performed for node-positive patients treated with adjuvant therapy. CEA immunoreactivity was not prognostically relevant in any subset of analysed patients. The most important prognostic markers were nodal status and tumour size

The extension of the one‐dimensional

While many studies have been conducted on the application of the one-dimensional (1D) two-fluid model in horizontal and nearly horizontal pipes under slug flow condition, very few works have been carried out on the mechanistic simulation of the slug flow regime in vertical pipe configurations. This article presents the extension of a novel numerical scheme for slug capturing in pipes in vertical slug flows. The original numerical scheme includes an 1D transient, hyperbolic five-equation two-fluid model, and it has been embodied in a computer code called 5ESCARGOTS (5 Equations for Slug Capturing Analysis by a Roe solver in Gas and Oil Transient Simulation). This article demonstrates that the model is able to properly automatically capture and simulate the slug generation even in vertical flow. It shows that when appropriate closure relations are used for interfacial shear forces, the model is able to properly characterize the vertical slug flow. Numerous simulations have been carried out for different pipe configurations and flow conditions leading to slug flow. First, a qualitative discussion of the numerical results is proposed underlining that the model is able to properly simulate the evolution of the slug flow in vertical pipes. Experimental flow pattern maps have also been numerically computed and it has been demonstrated that the model correctly simulates slug conditions. Moreover, slug frequency, velocity, and average liquid holdup, computed numerically, have been compared with experimental data in order to quantitatively validate the model. It is shown that the numerical results agree fairly well with the experimental data. A sensitivity analysis on the mesh size and on the inlet boundary conditions has also been carried out

The extension of the one-dimensional two-fluid slug capturing method to simulate slug flow in vertical pipes

While many studies have been conducted on the application of the one-dimensional (1D) two-fluid model in horizontal and nearly horizontal pipes under slug flow condition, very few works have been carried out on the mechanistic simulation of the slug flow regime in vertical pipe configurations. This article presents the extension of a novel numerical scheme for slug capturing in pipes in vertical slug flows. The original numerical scheme includes an 1D transient, hyperbolic five-equation two-fluid model, and it has been embodied in a computer code called 5ESCARGOTS (5 Equations for Slug Capturing Analysis by a Roe solver in Gas and Oil Transient Simulation). This article demonstrates that the model is able to properly automatically capture and simulate the slug generation even in vertical flow. It shows that when appropriate closure relations are used for interfacial shear forces, the model is able to properly characterize the vertical slug flow. Numerous simulations have been carried out for different pipe configurations and flow conditions leading to slug flow. First, a qualitative discussion of the numerical results is proposed underlining that the model is able to properly simulate the evolution of the slug flow in vertical pipes. Experimental flow pattern maps have also been numerically computed and it has been demonstrated that the model correctly simulates slug conditions. Moreover, slug frequency, velocity, and average liquid holdup, computed numerically, have been compared with experimental data in order to quantitatively validate the model. It is shown that the numerical results agree fairly well with the experimental data. A sensitivity analysis on the mesh size and on the inlet boundary conditions has also been carried out

A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman's Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment

A 38-year-old woman was referred to our hospital for rheumatologic manifestations (migrant arthritis and tenosynovitis), without psoriasis or family history of psoriasis, gastroenteric manifestations, or recent genitourinary infections. The instrumental and laboratory tests have suggested a diagnosis of undifferentiated seronegative HLA-B27-positive spondyloarthritis with predominantly peripheral involvement. The symptoms were very severe and resistant to anti-inflammatory drugs and steroids. She had a history of hyaline-vascular unicentric Castleman's disease (HBV, HIV, and HHV-8 negative) treated with surgery resection. After a first pharmacological attempt with sulfasalazine (suspended for urticarial rash), we managed the patient with monotherapy tocilizumab 8 mg/kg, with full response of rheumatologic manifestations. The efficacy of tocilizumab was confirmed even after a follow-up of three years. Our experience seems to describe a new late-onset autoimmune disease (only 21 cases described in literature) potentially related to Castleman's disease. The patient experienced marked improvement from IL-6-based therapy (tocilizumab)

Pelvic and muscular metastasis of a renal cell carcinoma: A case report.

We report a case of an uncommon site of metastasis of a renal cell carcinoma. The most common sites of renal cell carcinoma metastasis are the lung, lymph nodes, liver, bone and adrenal glands; skeletal muscle metastasis is a rare occurrence. We report the case of a 75-year-old female who underwent a laparoscopic left radical nephrectomy for a renal neoplasm in 2011. The histological examination revealed the presence of a renal cell carcinoma, Fuhrman grade 2, with extensive necrosis and phlogosis areas (TNM 2009 RCC pT2a). Ten months later, the patient noted an indolent swelling on the proximal third of the right thigh and underwent a ultrasonographic and CT evaluation, documenting the presence of a pathological, solid bulk in the front of the right iliac vessels and in the rectus femoris muscle. The fine needle biopsy revealed a metastasis of renal cell carcinoma. The patient underwent 4 cycles of sunitinib therapy, followed by 3 cycles of salvage therapy with sorafenib, which were well tolerated. This unpredictable behaviour of RCC suggests the need to perform a thorough follow-up of patients

L'angiomiolipoma renale multicentrico: contributo dell'immunoistochimica alla risoluzione di un problema clinico

L'angiomiolipoma renale multicentrico: contributo dell'immunoistochimica alla risoluzione di un problema clinic