The effects of sensory stimulation on students with traumatic brain injury as compared to students with developmental disabilities

The purpose of this research was to determine if Sensory Stimulation had an effect on the motor development and communication skills of the students with Traumatic Brain Injury as compared to the students with Developmental Disabilities. Four students participated in this study: two were Traumatic Brain Injured and the other two were Developmentally Disabled. To establish change over time the students\u27 communication and motor skills were observed individually three times a week for four weeks. Eight domains were covered; responses could be verbal or non-verbal. The results indicated that Sensory Stimulation proved to be beneficial because all four students showed some type of improvement. However, the Traumatic Brain Injured students responded significantly higher than the Developmentally Disabled students

Evocative gene-environment correlation between genetic risk for schizophrenia and bullying victimization

Bullying exposure concerns over 10% of adolescents in Europe. Moreover, bullying victimization is heritable and victims are liable to psychotic symptoms, partly because of shared heritability with psychosis. The genetic component of bullying victimization has been proposed to involve the social reactions elicited by victims – a mechanism called “evocative gene-environment correlation”. We hypothesized that genetic risk for schizophrenia, a heritable disease also associated with social stress during childhood and adolescence, is related with social experiences during adolescence and is involved in the risk of developing psychotic symptoms. We studied 908 individuals of the TRAILS sample and found that 13-14-year-old adolescents with greater genetic risk for schizophrenia are more exposed to bullying assessed via peer nomination scores than their peers with lower genetic risk. Importantly, bullying victimization mediated the path from genetic risk to the frequency of psychotic symptoms about three years later. These findings provide evidence of a previously unreported form of gene-environment interplay that may be a mechanism of risk for psychosis and schizophrenia. To the extent that genetic risk translation into clinical symptoms is mediated by environmental risk factors, this evidence supports mental health prevention aimed at antagonizing bullying victimization in vulnerable individuals

Modelling of the scatter in short fatigue cracks growth kinetics in relation with the polycrystalline microstructure

International audienceFinite element computations of the stresses ahead of a tortuous microcrack in a polycrystal (including crack flanks friction) are coupled with simulations of crystallographic crack growth based on discrete dislocations dynamics. An incubation period for crack growth beyond grain boundaries is introduced. The model reproduces the shape of experimental crack growth curves obtained on 316LN stainless steel and the decrease in arrest periods at grain boundaries as the crack grows. It predicts a large scatter in growth rates related to the variety of local textures. It also describes the fact that overloads allowing arrested cracks to cross the grain boundaries can make small cycles damaging

Performance evaluation of a Ball Screw mechanism through a multibody dynamic model

Ball screws are mechanism to convert the rotational into linear motion and viceversa and are widespread in a variety of different sectors. A detailed high-fidelity dynamic mathematical model of such component is paramount in several fields and, in particular, in the definition of a PHM system for flight control EMAs in order to increase their reliability. In fact they can be used as a virtual test bench on which inject artificial defects and study their effect on specific indicators. This paper presents a MBD model of a single-nut ball screw with internal recirculation able of describing the full dynamic of each internal component allowing a more in-depth understanding of the system behavior and poses the basis for PHM-oriented analyses on different degradations

Aplysina aerophoba (Nardo, 1833) (Porifera, Demospongiae): an unexpected miniaturised growth form from the tidal zone of Mediterranean caves: morphology and DNA barcoding

In the Mediterranean Sea, the two sponges of the genus Aplysina (A. aerophoba and A. cavernicola) are identified on the basis of their external morphology and the environment in which they live. During a research program on the sponge fauna in semi-submerged caves of the Italian coasts, we have sampled an abundant very small yellow sponge, often living in the tidal zone, which were attributed to the genus Aplysina. Failing to assign the samples to a species through classical taxonomic methodologies (growth form and skeleton arrangement) and for the particular environment where this sponge lives, we have decided to use the COI analysis to solve the taxonomic problem offered by these miniaturized specimens. The analysis indicated that, in spite of the morphological differences, they belong to A. aerophoba. During old detailed surveys, conducted in the '60 years in some of the studied caves, this species was not recorded. It is possible that its abundant presence is related to the modifications occurred in the Mediterranean sponge communities occurred in the last decades in relation to global warming

Evaluation of in vitro anti-inflammatory activity of five selected marine sponges against denaturation of protein-A pilot study

Background: Marine sponges are well renowned for producing bioactive secondary metabolites with drug leads. Screening of anti-inflammatory compounds from marine sponges is highly appreciated in the field of marine pharmacognosy due to their effectiveness and specificity over the most of synthetic non-steroidal anti-inflammatory drugs. In vitro models to test anti-inflammatory activity are considered obligatory prior to pre-clinical studies. Objective: To evaluate in vitro anti-inflammatory effect of crude extracts of five marine sponge samples (N=5), collected from Dehiwala, Colombo, Sri Lanka. Methodology: Identification of sponge species were based on morphology, spicule and skeleton analysis, using light microscopy. Each sponge crude extract (SCE) was tested for selected zoo- chemicals and against the denaturation of albumin to assess the anti-inflammatory activity. Diclofenac sodium was used as the reference drug. Results: Sponge samples were identified as 1) Stylissa sp, 2) Stylissa carteri, 3) Axinella sp., 4) Phakellia sp. and 5) Family Axinellidae. Zoo-chemical analysis indicated the presence of alkaloids, saponins, terpenoids, and sterols in sponge extracts in varying degree. Heat induced egg albumin denaturation was inhibited by 4 SCEs specifying marked anti-inflammatory activity. Accordingly, the 3 sponge crude extracts were more potent (IC50 = 22.74 for Sp. 02, 3.98 for Sp. 03 and 63.665\u3bcgmL -1for Sp. 05) than the of standard reference drug, Diclofinac sodium (IC50=147.02 \u3bcg/mL). Conclusions: Thus, the present study for the first time investigated in vitro anti-inflammatory activity of crude extract of 5 selected marine sponge species from Sri Lanka, out of which 3 were more potent than the reference diclofenac sodium. Therefore, isolation and characterization of bioactive compounds which are responsible for anti- inflammatory activity will lead to discover novel marine derived anti-inflammatory drugs in the future

Leveraging Semantic Web Service Descriptions for Validation by Automated Functional Testing

Recent years have seen the utilisation of Semantic Web Service descriptions for automating a wide range of service-related activities, with a primary focus on service discovery, composition, execution and mediation. An important area which so far has received less attention is service validation, whereby advertised services are proven to conform to required behavioural specifications. This paper proposes a method for validation of service-oriented systems through automated functional testing. The method leverages ontology-based and rule-based descriptions of service inputs, outputs, preconditions and effects (IOPE) for constructing a stateful EFSM specification. The specification is subsequently utilised for functional testing and validation using the proven Stream X-machine (SXM) testing methodology. Complete functional test sets are generated automatically at an abstract level and are then applied to concrete Web services, using test drivers created from the Web service descriptions. The testing method comes with completeness guarantees and provides a strong method for validating the behaviour of Web services

Cryotherapy of Liver Tumours–A Practical Guide

The use of cryotherapy for the treatment of some unresectable liver tumours has been clearly established as a therapeutic option. Intra-operative ultrasound has enhanced the process by enabling the surgeon to identify hepatic lesions and to allow visualisation of the freezing process to ensure that the cryolesion will include the tumour mass. The purpose of this paper is to provide a practical guide to surgeons who wish to perform cryotherapy of liver tumours. Patient selection and anaesthetic considerations are important. The surgeon should be able to deal with the complications of cryotherapy, particularly the intra-operative haemorrhage which may arise from cracking of the hepatic parenchyma as the iceball thaws. Follow-up is based on tumour marker assay and imaging of the liver and repeat cryotherapy can be considered for selected cases