Measurements design and phenomena discrimination

The construction of measurements suitable for discriminating signal components produced by phenomena of different types is considered. The required measurements should be capable of cancelling out those signal components which are to be ignored when focusing on a phenomenon of interest. Under the hypothesis that the subspaces hosting the signal components produced by each phenomenon are complementary, their discrimination is accomplished by measurements giving rise to the appropriate oblique projector operator. The subspace onto which the operator should project is selected by nonlinear techniques in line with adaptive pursuit strategies

From cardinal spline wavelet bases to highly coherent dictionaries

Wavelet families arise by scaling and translations of a prototype function, called the mother wavelet. The construction of wavelet bases for cardinal spline spaces is generally carried out within the multi-resolution analysis scheme. Thus, the usual way of increasing the dimension of the multi-resolution subspaces is by augmenting the scaling factor. We show here that, when working on a compact interval, the identical effect can be achieved without changing the wavelet scale but reducing the translation parameter. By such a procedure we generate a redundant frame, called a dictionary, spanning the same spaces as a wavelet basis but with wavelets of broader support. We characterize the correlation of the dictionary elements by measuring their 'coherence' and produce examples illustrating the relevance of highly coherent dictionaries to problems of sparse signal representation

Poly(neutral red) based hydrogen peroxide biosensor for chromium determination by inhibition measurements

Amperometric hydrogen peroxide enzyme inhibition biosensors based on horseradish peroxidase (HRP) immobilised on electropolymerised neutral red (NR) or directly on the surface of carbon film electrodes (CFE) have been successfully applied to the determination of toxic Cr(III) and Cr(VI). Parameters influencing the performance of the biosensor including the enzyme immobilisation method, the amount of hydrogen peroxide, applied potential and electrolyte pH were optimised. The inhibition of horseradish peroxidase by the chromium species was studied under the optimised conditions. Results from the quantitative analysis of chromium ions are discussed in terms of detection limit, linear range and sensitivity. The HRP kinetic interactions reveal mixed binding of Cr(III) with I50 = 3.8 μM and inhibition binding constant Ki = 11.3 μM at HRP/PNR/CFE biosensors and uncompetitive binding of Cr(VI) with I50 = 3.9 μM and Ki = 0.78 μM at HRP/CFE biosensors in the presence of H2O2 substrate. Interferences from other heavy metal ions were studied and the inhibition show very good selectivity towards Cr(III) and Cr(VI)

Evaluation of freeway high occupancy vehicle lanes and ramp metering. Volume I. Final report.

Transportation Department, Office of the Assistant Secretary for Policy and International Affairs, Washington, D.C.Mode of access: Internet.Author corporate affiliation: Baugh, D., and Associates, Inc., Boston, Mass.Report covers the period Nov 1978-March 1980Subject code: HBEKSubject code: CDCMSubject code: CDKSubject code: GGOSubject code: WW*IJSubject code: X

Impact of demographic and migration trends on future travel in metropolitan areas. Final report.

Transportation Department, Office of the Assistant Secretary for Policy and International Affairs, Washington, D.C.Mode of access: Internet.Author corporate affiliation: SG Associates, Inc., Annandale, Va.Subject code: KBMSSubject code: SBCSubject code: SCDCSubject code: SDBFSubject code: YC

Pharmacist-Managed Inpatient Dofetilide Initiation Program: Description and Adherence Rate Post-Root Cause Analysis.

The aim of this article is to describe the pharmacist-managed dofetilide initiation program at Maine Medical Center (MMC), assess the adherence rate to 8 core clinical metrics, and review adverse effects before and after a root cause analysis (RCA). Core clinical metrics included pharmacist note entered within 4 hours of dose administration, dose chosen correctly per renal function, QTc measurements obtained and reviewed 2 hours after each dose, appropriate dose adjustment per the most recent QTc measurement, documentation of patient education, and assessment of conduction abnormality, drug-drug interactions, and serum potassium and magnesium concentrations. The primary outcome was adherence rate to all 8 core clinical metrics before and after the RCA. The safety outcome was the total number of adverse events. One hundred patients undergoing elective dofetilide initiation were evaluated: 50 pre-RCA and 50 post-RCA. Adherence rate to all core metrics was 14% in the pre-RCA group and 44% in the post-RCA group ( P \u3c .001). Torsade de pointes occurred 3 times in the pre-RCA group and never in the post-RCA group. After the RCA, adherence to MMC\u27s pharmacist-managed inpatient dofetilide initiation program significantly improved