Application of a wavelet technique for the detection of earthquake signatures in the geomagnetic field

We developed an algorithm especially adapted to <i>single-station </i>wavelet detection of geomagnetic events, which precede or accompany the earthquakes. The detection problem in this situation is complicated by a great variability of earthquakes and accompanied phenomena, which aggravates finding characteristic features of the events. Therefore we chose to search for the characteristic features of both &quot;disturbed&quot; intervals (containing earthquakes) and &quot;quiet&quot; recordings. In this paper we propose an algorithm for solving the problem of detecting the presence of signals produced by an earthquake via analysis of its signature against the existing database of magnetic signals. To achieve this purpose, we construct the magnetic signature of certain earthquakes using the distribution of the energies among blocks, which consist of wavelet packet coefficients

Controlling the spin orientation of photoexcited electrons by symmetry breaking

We study reflection of optically spin-oriented hot electrons as a means to probe the semiconductor crystal symmetry and its intimate relation with the spin-orbit coupling. The symmetry breaking by reflection manifests itself by tipping the net-spin vector of the photoexcited electrons out of the light propagation direction. The tipping angle and the pointing direction of the net-spin vector are set by the crystal-induced spin precession, momentum alignment and spin-momentum correlation of the initial photoexcited electron population. We examine non-magnetic semiconductor heterostructures and semiconductor/ferromagnet systems and show the unique signatures of these effects.Comment: 4 pages, 3 figures, resubmitte

Terahertz radiation driven chiral edge currents in graphene

We observe photocurrents induced in single layer graphene samples by illumination of the graphene edges with circularly polarized terahertz radiation at normal incidence. The photocurrent flows along the sample edges and forms a vortex. Its winding direction reverses by switching the light helicity from left- to right-handed. We demonstrate that the photocurrent stems from the sample edges, which reduce the spatial symmetry and result in an asymmetric scattering of carriers driven by the radiation electric field. The developed theory is in a good agreement with the experiment. We show that the edge photocurrents can be applied for determination of the conductivity type and the momentum scattering time of the charge carriers in the graphene edge vicinity.Comment: 4 pages, 4 figure, additional Supplemental Material (3 pages, 1 figure

Дренирование области поджелудочной железы при хирургических вмешательствах на ней

On the basis of the analysis of cases 713 patients were revealed postoperative complications because of shortcoming of drainage of pancreas area at surgical treatment of different pancreas diseases. Тhe new method drainage of pancreas area in clinic was elaborated for liquidation of shortcoming offered before methods drainage.На основании анализа наблюдений 713 больных выявлены послеоперационные осложнения, связанные с недостаточным дренированием области поджелудочной железы при хирургическом лечении различных заболеваний ее. Для ликвидации недостатков предложенных ранее методов дренирования в клинике разработан новый метод дренирования области железы

Regression of advanced diabetic nephropathy by hepatocyte growth factor gene therapy in rats

Diabetic nephropathy is the main cause of end-stage renal disease requiring dialysis in developed countries. In this study, we demonstrated the therapeutic effect of hepatocyte growth factor (HGF) on advanced rather than early diabetic nephropathy using a rat model of streptozotocin-induced diabetes. Early diabetic nephropathy (16 weeks after induction of diabetes) was characterized by albuminuria, hyperfiltration, and glomerular hypertrophy, whereas advanced diabetic nephropathy showed prominent transforming growth factor (TGF)-beta1 upregulation, mesangial expansion, and glomerulosclerosis. An SP1017-formulated human HGF (hHGF) plasmid was administered by intramuscular injection combined with electroporation over a 30-day follow-up in rats with early and advanced diabetic nephropathy. hHGF gene therapy upregulated endogenous rat HGF in the diabetic kidney (rat HGF by RT-PCR was threefold higher than in diabetic rats without therapy). hHGF gene therapy did not improve functional or morphologic abnormalities in early diabetic nephropathy. hHGF gene therapy reduced albuminuria and induced strong regression of mesangial expansion and glomerulosclerosis in advanced diabetic nephropathy. These findings were associated with suppression of renal TGF-beta1 and mesangial connective tissue growth factor (CTGF) upregulation, inhibition of renal tissue inhibitor of metalloproteinase (TIMP)-1 expression, and reduction of renal interstitial myofibroblasts. In conclusion, our results suggest that hHGF gene therapy may be considered as an innovative therapeutic strategy to treat advanced diabetic nephropathy

Multicolor plate reader fluorescence calibration

Plate readers are commonly used to measure cell growth and fluorescence, yet the utility and reproducibility of plate reader data is limited by the fact that it is typically reported in arbitrary or relative units. We have previously established a robust serial dilution protocol for calibration of plate reader measurements of absorbance to estimated bacterial cell count and for green fluorescence from proteins expressed in bacterial cells to molecules of equivalent fluorescein. We now extend these protocols to calibration of red fluorescence to the sulforhodamine-101 fluorescent dye and blue fluorescence to Cascade Blue. Evaluating calibration efficacy via an interlaboratory study, we find that these calibrants do indeed provide comparable precision to the prior calibrants and that they enable effective cross-laboratory comparison of measurements of red and blue fluorescence from proteins expressed in bacterial cells

Хирургическое и криохирургическое лечение рецидивного альвеококкоза печени

The autors present the results of surgical treatment of 6 patients having hepatic recurrent alveolar echinococcosis. Five patients underwent re-resection of the liver (one patient underwent cryodestruction of liver stamp, another patient underwent spitting and marsupialization of the parasite with cryodestruction of parasitogenic tissue.В статье приводятся результаты хирургического лечения шести пациентов с рецидивным альвеококкозом печени. Пяти пациентам проведены ререзекции печени (одной из них выполнена криодеструкция культи печени), одному больному – кускование и марсупиализация паразита с криодеструкцией паразитарной ткани

Positron-emission tomography–based staging reduces the prognostic impact of early disease progression in patients with follicular lymphoma

Background: Previous studies reported that early progression of disease (POD) after initial therapy predicted poor overall survival (OS) in patients with follicular lymphoma (FL). Here, we investigated whether pre-treatment imaging modality had an impact on prognostic significance of POD. Methods: In this retrospective study, we identified 1088 patients with grade I–IIIA FL; of whom, 238 patients with stage II–IV disease were initially treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP), and 346 patients were treated with rituximab-based chemotherapy. Patients (N = 484) from the FOLL05 study served as an independent validation cohort. We risk-stratified patients based on pre-treatment radiographic imaging (positron-emission tomography [PET] versus computed tomography [CT]) and early POD status using event-defining and landmark analyses. A competing risk analysis evaluated the association between early POD and histologic transformation. Results: In the discovery cohort, patients with POD within 24 months (PFS24) of initiating R-CHOP therapy had a 5-year OS of 57.6% for CT-staged patients compared with 70.6% for PET-staged patients. In the validation cohort, the 5-year OS for patients with early POD was 53.9% and 100% in CT- and PET-staged patients, respectively. The risk of histologic transformation in patients whose disease progressed within one year of initiating therapy was higher in CT-staged patients than in PET-staged patients (16.7% versus 6.3%, respectively), which was associated with a 9.7-fold higher risk of death. Conclusion: In FL, pre-treatment PET staging reduced the prognostic impact of early POD compared with CT staging. Patients with early POD and no histologic transformation have an extended OS with standard therapy

Криохирургия очаговых поражений печени

The results of cryosurgical treatment of 339 patients with various focal liver diseases are presented. The experience of using cryosurgical equipment designed and manufactured in the Tomsk Hepatological Center in the surgery of focal liver diseases is analyzed. The application of inventive instruments in the liver resection leads to a decrease in the intraoperative blood loss down to 30- 40% and favors the reduction of backsets, because the cryodestruction of liver stump after resection leads to the destruction of rest parts of parasitic tissue in the surgical zone. The use of cryosurgical techniques lowers the number of deaths down to 4.42%.Представлены результаты лечения 339 больных после криохирургических операций на печени при различных очаговых поражениях этого органа. Проанализирован опыт применения в хирургии очаговых поражений печени оригинальной криохирургической техники, созданной в Томском гепатологическом центре. Применение инструментов оригинальной конструкции во время резекции печени приводит к снижению интраоперационной кровопотери до 30—40%, а также способствует уменьшению количества рецидивов заболевания, поскольку криодеструкция культи печени после резекции ведет к разрушению оставленных участков паразитарной ткани в зоне операции. Использование криохирургических методик позволяет снизить частоту летальных исходов до 4,42%