An Investigation of Perception of Business Process Reengineering in Indian Manufacturing Industry

The progress of manufacturing industry still sets the tone for the overall business cycle and the health of this sector is very much at the core of India's socio-economic fabric and hence the Government of India is erecting a pentagon of corridor to boost manufacturing sector and to project India as a Global Manufacturing hub of the world. To compete globally Indian manufacturing sector needs to undergo radical change and Business Process Reengineering (BPR) is one such tool  for competing in the dynamic business environment. Although BPR as change initiative has various methodologies, techniques and tools for implementation, but these methodologies fail to demonstrate  their effectiveness in the absence of clear understanding and the perceptions of the employees  towards the initiative. Based on the perception, the organization will identify the right approach towards the BPR implementation and develop relevant appropriate plans for smooth and successful BPR effort.This study aims at investigating the several understandings of BPR in  various manufacturing sectors across India by  gaging the perception of the internal customers towards  BPR effort . The primary data  was collected from the various manufacturing industries comprising of Small Scale , Medium scale , Large scale, Very Large scale and Multi National Companies across India using structured  self-administered questionnaire. Upon investigation using One-way ANOVA , it is observed that the Indian manufacturing industry has positive approach towards BPR effort across different scales of the organizations and hence makes it fertile for change initiatives. Keywords: BPR, Business Process Reengineering, Perception, Indian, Manufacturing Sector, Make In India, ANOV

Exploration of Critical Organizational Climate Factors Impacting BPR Implementation: A Survey of Indian Companies

Business Process Reengineering ( BPR) is considered to be one of the most effective techniques  used by  the manufacturing organizations in dealing with turbulent global economy and ever-changing customer’s preferences. Implementation of BPR brings along with it many changes within the organization. This study attempts to understand and validate the organizational climate factors for effective change management Though extensive research has been done  worldwide, very few empirical studies have been carried out in India. The study is based on the various success / failure factors proposed by Al-Mashari. It is hoped that better understanding of the factors will lead to higher success rates of BPR implementation. The primary data  was collected from the various manufacturing industries comprising of Small Scale , Medium scale , Large scale and Multi National Companies across India using structured  self-administered questionnaire. Principal Component Analaysis ( PCA)  with varimax rotation using SPSS19.0 was carried out in order to verify the factors proposed on the basis of literature review with respect to Indian manufacturing Sector. Upon investigation it was observed that the factors were reduced to five without omitting the items and were renamed as Organizational Culture , Educations and training , Empowerment , Equitable Compensation and Team Work. Finally it was concluded that Proper identification and adequate understanding of the organizational climate factors fostering change adaptation becomes key ingredient for successful implementation of BPR effort. Keywords : BPR, Business Process Reengineering, Organizational climate, Indian, Manufacturing Sector, Critical factors, Organizational Cultur

Cofinite Graphs and Their Profinite Completions

We generalize the idea of cofinite groups, due to B. Hartley, [2]. First we define cofinite spaces in general. Then, as a special situation, we study cofinite graphs and their uniform completions.The idea of constructing a cofinite graph starts with defining a uniform topological graph $\Gamma$, in an appropriate fashion. We endow abstract graphs with uniformities corresponding to separating filter bases of equivalence relations with finitely many equivalence classes over $\Gamma$. It is established that for any cofinite graph there exists a unique cofinite completion

Brans-Dicke Wormhole Revisited

A basic constraint to be satisfied by Brans class I solution for being a traversible wormhole is derived. It is argued that the solution could be a wormhole analogue of the Horowitz-Ross naked black hole. It is further demonstrated that the wormhole is traversible only "in principle", but not in practice. Using a recently proposed measure of total gravitational energy inside a static wormhole configuration, it is shown that the wormhole contains repulsive gravity required for the defocussing of orbits at the throat.Comment: 13 pages, 6 figures, accepted for publication in Class. Quant. Gra

Exposure to Host Ligands Correlates with Colocalization of Gal/GalNAc Lectin Subunits in Lipid Rafts and Phosphatidylinositol (4,5)-Bisphosphate Signaling in Entamoeba histolytica

Entamoeba histolytica is an intestinal parasite that causes dysentery and liver abscess. Parasite cell surface receptors, such as the Gal/GalNAc lectin, facilitate attachment to host cells and extracellular matrix. The Gal/GalNAc lectin binds to galactose or N-acetylgalactosamine residues on host components and is composed of heavy (Hgl), intermediate (Igl), and light (Lgl) subunits. Although Igl is constitutively localized to lipid rafts (cholesterol-rich membrane domains), Hgl and Lgl transiently associate with this compartment in a cholesterol-dependent fashion. In this study, trophozoites were exposed to biologically relevant ligands to determine if ligand binding influences the submembrane distribution of the subunits. Exposure to human red blood cells (hRBCs) or collagen, which are bona fide Gal/GalNAc lectin ligands, was correlated with enrichment of Hgl and Lgl in rafts. This enrichment was abrogated in the presence of galactose, suggesting that direct lectin-ligand interactions are necessary to influence subunit location. Using a cell line that is able to attach to, but not phagocytose, hRBCs, it was shown that physical attachment to ligands was not sufficient to induce the enrichment of lectin subunits in rafts. Additionally, the mutant had lower levels of phosphatidylinositol (4,5)-bisphosphate (PIP2); PIP2 loading restored the ability of this mutant to respond to ligands with enrichment of subunits in rafts. Finally, intracellular calcium levels increased upon attachment to collagen; this increase was essential for the enrichment of lectin subunits in rafts. Together, these data provide evidence that ligand-induced enrichment of lectin subunits in rafts may be the first step in a signaling pathway that involves both PIP2 and calcium signaling

A Nonsingular Brans Wormhole: An Analogue to Naked Black Holes

In a recent paper, we showed the Jordan frame vacuum Brans Class I solution provided a wormhole analogue to Horowitz-Ross naked black hole in the wormhole range -3/2<{\omega}<-4/3. Thereafter, the solution has been criticized by some authors that, because of the presence of singularity in that solution within this range, a wormhole interpretation of it is untenable. While the criticism is correct, we show here that (i) a singularity-free wormhole can actually be obtained from Class I solution by performing a kind of Wick rotation on it, resulting into what Brans listed as his independent Class II solution (ii) the Class II solution has all the necessary properties of a regular wormhole in a revised range -2<{\omega}<-3/2 and finally, (iii) naked black holes, as described by Horowitz and Ross, are spacetimes where the tidal forces attain their maxima above the black hole horizon. We show that in the non-singular Class II spacetime this maxima is attained above the throat and thus can be treated as a wormhole analogue. Some related issues are also addressed.Comment: 20 pages, 4 figure

Characterization of eDNA from the Clinical Strain Acinetobacter baumannii AIIMS 7 and Its Role in Biofilm Formation

Release of extracellular DNA (eDNA) was observed during in vitro growth of a clinical strain of Acinetobacter baumannii. Membrane vesicles (MV) of varying diameter (20–200 nm) containing DNA were found to be released by transmission electron microscopy (TEM) and atomic force microscopy (AFM). An assessment of the characteristics of the eDNA with respect to size, digestion pattern by DNase I/restriction enzymes, and PCR-sequencing, indicates a high similarity with genomic DNA. Role of eDNA in static biofilm formed on polystyrene surface was evaluated by biofilm augmentation assay using eDNA available in different preparations, for example, whole cell lysate, cell-free supernatant, MV suspension, and purified eDNA. Biofilm augmentation was seen up to 224.64%, whereas biofilm inhibition was 59.41% after DNase I treatment: confirming that eDNA facilitates biofilm formation in A. baumannii. This is the first paper elucidating the characteristics and role of eDNA in A. baumannii biofilm, which may provide new insights into its pathogenesis

Comparison of the diagnostic accuracy of three current guidelines for the evaluation of asymptomatic pancreatic cystic neoplasms.

Asymptomatic pancreatic cysts are a common clinical problem but only a minority of these cases progress to cancer. Our aim was to compare the accuracy to detect malignancy of the 2015 American Gastroenterological Association (AGA), the 2012 International Consensus/Fukuoka (Fukuoka guidelines [FG]), and the 2010 American College of Radiology (ACR) guidelines.We conducted a retrospective study at 3 referral centers for all patients who underwent resection for an asymptomatic pancreatic cyst between January 2008 and December 2013. We compared the accuracy of 3 guidelines in predicting high-grade dysplasia (HGD) or cancer in resected cysts. We performed logistic regression analyses to examine the association between cyst features and risk of HGD or cancer.A total of 269 patients met inclusion criteria. A total of 228 (84.8%) had a benign diagnosis or low-grade dysplasia on surgical pathology, and 41 patients (15.2%) had either HGD (n = 14) or invasive cancer (n = 27). Of the 41 patients with HGD or cancer on resection, only 3 patients would have met the AGA guideline\u27s indications for resection based on the preoperative cyst characteristics, whereas 30/41 patients would have met the FG criteria for resection and 22/41 patients met the ACR criteria. The sensitivity, specificity, positive predictive value, negative predictive value of HGD, and/or cancer of the AGA guidelines were 7.3%, 88.2%, 10%, and 84.1%, compared to 73.2%, 45.6%, 19.5%, and 90.4% for the FG and 53.7%, 61%, 19.8%, and 88% for the ACR guidelines. In multivariable analysis, cyst size \u3e3 cm, compared to ≤3 cm, (odds ratio [OR] = 2.08, 95% confidence interval [CI] = 1.11, 4.2) and each year increase in age (OR = 1.07, 95% CI = 1.03, 1.11) were positively associated with risk of HGD or cancer on resection.In patients with asymptomatic branch duct-intraductal papillary mucinous neoplasms or mucinous cystic neoplasms who underwent resection, the prevalence rate of HGD or cancer was 15.2%. Using the 2015 AGA criteria for resection would have missed 92.6% of patients with HGD or cancer. The more inclusive FG and ACR had a higher sensitivity for HGD or cancer but lower specificity. Given the current deficiencies of these guidelines, it will be important to determine the acceptable rate of false-positives in order to prevent a single true-positive

HIV Status Does Not Affect the Outcome of Autologous Stem Cell Transplantation (ASCT) for Non-Hodgkin Lymphoma (NHL)

Randomized trials comparing autologous stem cell transplant (ASCT) to conventional chemotherapy have demonstrated superior survival among HIV-negative ASCT patients with relapsed non-Hodgkin lymphoma (NHL). Recent trials explored the feasibility of ASCT in the HIV setting. Although these studies have shown that ASCT in HIV-positive NHL patients (HIVpos-NHL) is well tolerated, the impact of HIV infection on long-term transplant outcome is not well characterized. Ongoing comparison of long-term survival following ASCT in HIVpos-NHL patients and HIVneg-NHL patients will allow investigators to explore whether there should be inclusion of HIVpos-NHL patients in ASCT trials. To study long-term outcome we conducted a single-institution matched case-controlled study in HIVpos-NHL patients (cases) and HIVneg-NHL patients (controls). Twenty-nine patients with HIVpos-NHL were matched with HIVneg-NHL controls on sex, time to ASCT, year of transplant, histology, age, disease status, number prior regimens, and conditioning regimen. Nonrelapse mortality (NRM) was similar: 11% (95% confidence interval [CI]: 4%-28%) in HIVpos-NHL patients and 4% (95% CI: 1%-25%) in HIVneg-NHL controls (P = .18). Two-year disease-free survival (DFS) for the HIVpos-NHL patients was 76% (95% CI: 62%-85%) and 56% (95% CI: 45%-66%) for the HIVneg-NHL controls (P = .33). Overall survival was also similar; the 2-year point estimates were 75% (95% CI: 61%-85%) and 75% (95% CI: 60%-85%), respectively (P = .93), despite inclusion of more poor risk HIVpos-NHL patients. These results provide further evidence that HIV status does not affect the long-term outcome of ASCT for NHL, and therefore HIV status alone should no longer exclude these patients from transplant clinical trials