Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy

Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect. Material: Twelve-week old maleWistar albino rats were used in this study. Twenty-four rats were equally divided into four groups which were named as: sham group, EMR-only, EMR+L-carnitine (1.5 mg L-carnitine/ kg/day) and EMR+Se (1.5 mg Se/kg/ every other day). Results: The level of Bcl-2, Bax, caspase-3 and -8 were compared and a significant difference was found between the sham and EMR-only groups (p < 0.05), and Bcl-2, Bax, caspase-3 and -8 expressions increased in the EMR-only group. The level of Bcl-2, Bax, tumour necrosis factor-alpha (TNF-α), caspase- 3 and -8 were compared and a significant difference was found between the sham and EMR+L-carnitine groups (p < 0.05) and Bcl-2, Bax, TNF-α, caspase-3 and -8 expressions increased in the EMR+L-carnitine group. The level of Bcl-2, Bax, TNF-α, caspase-3 and -8 were compared and a significant difference was found between the sham and EMR+Se groups (p < 0.05) and Bcl-2, Bax, TNF-α, caspase-3 and -8 expressions increased in the EMR+Se group. When the expression of caspase-8 was compared, a significant difference was found between the EMR-only and EMR+Se groups (p < 0.05). Caspase-8 expression decreased in EMR+Se group compared with EMR-only group. Conclusion: Electromagnetic radiation exposure resulted in testicular apoptosis in rats, mainly by the intrinsic pathways by down-regulated expression of caspase-8. Reduction in the activation of the intrinsic pathway of apoptosis was found higher with selenium administration compared with L-carnitine administration

On the evolution of the radio pulsar PSR J1734−3333

Recent measurements showed that the period derivative of the ‘hig h-B’ radio pulsar PSR J1734−3333 is increasing with time. For neutron stars evolving with fallback disks, this rotational behavior is expected in certain phases of the long-term evolution. Using the same model as employed earlier to explain the evolution of anomalous X-ray pulsars and soft gamma-ray repeaters, we show that the period,the first and second period derivatives and the X-ray luminosity of this source can simultaneously acquire the observed values for a neutron star evolving with a fallback disk. We find that the required strength of the dipole field that can produce the source properties is in the range of 10^12 − 10^13 G on the pole of the neutron star. When the model source reaches the current state properties of PSR J1734−3333, accretion onto the star has not started yet, allowing the source to operate as a regular radio pulsar. Our results imply that PSR J1734−3333 is at an age of ∼3×10^4 −2×10^5years. Such sources will have properties like the X-ray dim isolated neutron stars or transient AXPs at a later epoch of weak accretion from the diminished fallback disk

Antecedents and consequences of effectuation and causation in the international new venture creation process

The selection of the entry mode in an international market is of key importance for the venture. A process-based perspective on entry mode selection can add to the International Business and International Entrepreneurship literature. Framing the international market entry as an entrepreneurial process, this paper analyzes the antecedents and consequences of causation and effectuation in the entry mode selection. For the analysis, regression-based techniques were used on a sample of 65 gazelles. The results indicate that experienced entrepreneurs tend to apply effectuation rather than causation, while uncertainty does not have a systematic influence. Entrepreneurs using causation-based international new venture creation processes tend to engage in export-type entry modes, while effectuation-based international new venture creation processes do not predetermine the entry mod

Morphological and Physiological Responses to Drought Stress of European Provenances of Scots Pine

Increased frequency and intensity of drought episodes as a consequence of current and predicted climatic changes require an understanding of the intra-specific variability in structural and physiological characteristics of forest trees. Adaptive plasticity and genotypic variability are considered two of the main processes by which trees can either be selected or can acclimate to changing conditions. We tested for the relative importance of genotypic variability, phenotypic plasticity and their interaction by comparing the growth and physiological performance of 15 provenances of Scots pine (Pinus sylvestris L.), under two contrasting irrigation regimes. Selected provenances representing the distribution range of the species in Anatolia, Turkey, were contrasted with seed sources spanning the range from Spain to the UK, in Europe. We found a strong latitudinal differentiation among the 15 provenances for survival after drought, largely the result of the higher mortality of some western and central European provenances. Differentiation in diameter and height growth was also clear with the worst provenance coming from Western Europe (UK). Among the Turkish provenances, the more extreme southern high-elevation populations showed greater survival and lower growth rates overall. Differences in growth and survival were related to differences in photosynthetic pigment and nutrient contents and in the photosynthetic efficiency of photosystem II. Plasticity was strongest for growth characters and pigment contents.WoSScopu

Transport through small world networks

7 pages, 8 figures, 1 appendix.We numerically investigate the transport properties through a system where small world networks are added to a one-dimensional chain. One-electron Green's function method is applied to standard tight-binding Hamiltonians on networks, modeled as (i) adding connections between any two nonadjacent random sites in the chain, (ii) introducing finite one-dimensional chains between any pair of such connected sites, and (iii) attaching finite dangling chains at random sites in the chain. Due to the small world bonds and dangling conduction paths, the systems have irregular geometrical shapes, leading to quenched disordered systems. We consider the qualitative influence of the small world bonds and dangling bonds on the transmittance and find that the systems exhibit a strong energy dependence on the transmittance, with strong sample-to-sample fluctuations.Peer reviewe