The thickness of the calcified layer in different joints of a single individual

The thickness of the articular cartilage and its calcified zone were both measured at specially chosen places in several limb joints from five subjects. The volume of the calcified zone expressed as a percentage of the total cartilage was not only constant for one joint, but also in all the joints of a single individual. Nevertheless, the variation between subjects ranges from 6.9 to 8.6%. In two cases both sides of the body were investigated. As was the case in an earlier investigation on the femoral head, the bilateral distribution of the thickness was the same. Since the thickness of the total cartilage varies with the local distribution of loading in the joint, it follows that the thickness of the calcified layer also depends upon mechanical factors. Five subjects is too few to allow correlation with age or sex to be either refuted or confirmed. There is some evidence in the existing literature that the thickness of the calcified zone may be altered by diseas

Stability of the Enhanced Area Law of the Entanglement Entropy

We consider a multi-dimensional continuum Schr\"odinger operator which is given by a perturbation of the negative Laplacian by a compactly supported potential. We establish both an upper and a lower bound on the bipartite entanglement entropy of the ground state of the corresponding quasi-free Fermi gas. The bounds prove that the scaling behaviour of the entanglement entropy remains a logarithmically enhanced area law as in the unperturbed case of the free Fermi gas. The central idea for the upper bound is to use a limiting absorption principle for such kinds of Schr\"odinger operators.Comment: Changes in v2: result extended from cubes to Lipschitz domains with piecewise smooth boundar

Computed tomography-osteoaboorptiometry

A method of making a visual display of subchondral mineralization in the major synovial joints is described. Unlike existing procedures, it can be used on the living subject. A modified application of computed tomography-densitometry, computed tomography-osteoabsorptiometry makes it possible to explore the mechanical adaptability to the prevailing mechanical force. This claim is based upon the comparison of information obtained from 20 anatomical specimens with CT-osteoabsorptiometry and x-ray densitometry of sections; both methods yielding virtually identical results. The distribution of the subchondral density was then expressed as a map of the articular surface with the aid of an image analyser. This method can make a useful contribution to basic clinical research, as well as providing a diagnostic technique which can also be used for observing progress after a corrective osteotomy or any other procedure causing a change in mechanical function. Examples of its use on living patients are given

Physiological incongruity of the humero-ulnar joint

Investigations into the distribution of subchondral bone density in the human elbow have suggested that the geometry of the trochlear notch deviates from a perfect fit with the trochlea, and that the load is transmitted ventrally and dorsally rather than through the centre of the humero-ulnar joint. We therefore decided to make a quantitative assessment of the degree of incongruity between the two components in 15 human specimens (age distribution 60 to 93 years) with different types of joint surface. Polyether casts of the joint cavity were prepared under loads of 10,40,160 and 640 N. The thickness of the casts was then measured at 50 predetermined points, and an area distribution of the width of the joint space represented in a two-dimensional template of the trochlear notch. The reproducibility of this procedure was tested by image analysis. At a load of 10 N, only a narrow space was present ventrally and dorsally in the joint, but in the depths of the trochlear notch a width of 0.5 to 1 mm was recorded in the centre, and up to 3 mm at its medial and lateral edges. Specimens with continuous articular cartilage showed a lower degree of incongruity than those with a divided articular surface. As the load was increased to 640 N, however, the original incongruity between the articular surfaces disappeared almost completely. The joint surfaces became more congruous, probably because of the viscoelastic properties of the articular cartilage and the subchondral bone, and the contact areas merged in the centre of the joint. It is suggested that this physiological incongruity brings about an optimal distribution of stress over the articular surface during the transmission of the load, and it may lead to better nourishment of the articular cartilage by providing intermittent mechanical stimulation and circulation of the synovial fluid

Evidence for the late MMN as a neurophysiological endophenotype for dyslexia.

Dyslexia affects 5-10% of school-aged children and is therefore one of the most common learning disorders. Research on auditory event related potentials (AERP), particularly the mismatch negativity (MMN) component, has revealed anomalies in individuals with dyslexia to speech stimuli. Furthermore, candidate genes for this disorder were found through molecular genetic studies. A current challenge for dyslexia research is to understand the interaction between molecular genetics and brain function, and to promote the identification of relevant endophenotypes for dyslexia. The present study examines MMN, a neurophysiological correlate of speech perception, and its potential as an endophenotype for dyslexia in three groups of children. The first group of children was clinically diagnosed with dyslexia, whereas the second group of children was comprised of their siblings who had average reading and spelling skills and were therefore "unaffected" despite having a genetic risk for dyslexia. The third group consisted of control children who were not related to the other groups and were also unaffected. In total, 225 children were included in the study. All children showed clear MMN activity to/da/-/ba/contrasts that could be separated into three distinct MMN components. Whilst the first two MMN components did not differentiate the groups, the late MMN component (300-700 ms) revealed significant group differences. The mean area of the late MMN was attenuated in both the dyslexic children and their unaffected siblings in comparison to the control children. This finding is indicative of analogous alterations of neurophysiological processes in children with dyslexia and those with a genetic risk for dyslexia, without a manifestation of the disorder. The present results therefore further suggest that the late MMN might be a potential endophenotype for dyslexia

Longitudinal Assessment of In Vivo Bone Dynamics in a Mouse Tail Model of Postmenopausal Osteoporosis

Recently, it has been shown that transient bone biology can be observed in vivo using time-lapse micro-computed tomography (μCT) in the mouse tail bone. Nevertheless, in order for the mouse tail bone to be a model for human disease, the hallmarks of any disease must be mimicked. The aim of this study was to investigate whether postmenopausal osteoporosis could be modeled in caudal vertebrae of C57Bl/6mice, considering static and dynamic bone morphometry as well as mechanical properties, and to describe temporal changes in bone remodeling rates. Twenty C57Bl/6mice were ovariectomized (OVX, n=11) or sham-operated (SHM, n=9) and monitored with in vivo μCT on the day of surgery and every 2weeks after, up to 12weeks. There was a significant decrease in bone volume fraction for OVX (−35%) compared to SHM (+16%) in trabecular bone (P<0.001). For OVX, high-turnover bone loss was observed, with the bone resorption rate exceeding the bone formation rate (P<0.001). Furthermore there was a significant decrease in whole-bone stiffness for OVX (−16%) compared to SHM (+11%, P<0.001). From these results we conclude that the mouse tail vertebra mimics postmenopausal bone loss with respect to these parameters and therefore might be a suitable model for postmenopausal osteoporosis. When evaluating temporal changes in remodeling rates, we found that OVX caused an immediate increase in bone resorption rate (P<0.001) and a delayed increase in bone formation rate (P<0.001). Monitoring transient bone biology is a promising method for future researc

Die Darstellung der subchondralen Dichtemuster mittels der CT-Osteoabsorptiometrie (CT-OAM) zur Beurteilung der individuellen Gelenkbeanspruchung am Lebenden

The researches of Pauwels and those following him have demonstrated that the subchondral bone density distribution below the surface of a joint is a metrical parameter which mirrors the predominant stress acting on that joint. Their technique of x-ray densitometry cannot, however, be used during life. By employing computer tomography, a new method has been developed - CT-osteoabsorptiometry (CT-OAM) - which can be used to obtain the density distribution pattern in the living subject. By means of a comparative investigation on specimens which were examined both with traditional x-ray densitometry and with CT absorptiometry, it has been shown that the new method can produce the same results, but providing the great advantage to be used on the living. In addition, the density distribution pattern of the glenoid cavity has been examined in patients with various shoulder conditions, and also in gymnasts who exercise on the rings. The distribution of subchondral bone density showed different patterns in the different groups examined. Both the comparison of the methods and the subsequent study confirmed that CT osteoabsorptiometry enables assessment to be made of the individual long-term stresses acting on a living joint