New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism

Managing deep restructuring:: Danish experiences in Eastern Germany

This paper discusses the restructuring in post-socialist economies. Case evidence from East Germany illustrates that foreign investors must do more than provide crucial resources and integrate firms into global production networks. They also have to become involved in the process of organizational change in the enterprise itself. This is often inhibited by compatibility problems and discrepancies between the new strategic management and the local organizational culture which evolved under socialism. Therefore, post-acquisition management in former socialist firms needs to take an evolutionary approach to organizational change, to facilitate the process of organizational integration, and to train employees to operate in a market-economy which requires the communication of tacit managerial and organizational knowledge. This paper offers some suggestions as to how this may be done.

The Pointer Assertion Logic Engine

We present a new framework for verifying partial specifications of programs in order to catch type and memory errors and check data structure invariants. Our technique can verify a large class of data structures, namely all those that can be expressed as graph types. Earlier versions were restricted to simple special cases such as lists or trees. Even so, our current implementation is as fast as the previous specialized tools. Programs are annotated with partial specifications expressed in Pointer Assertion Logic, a new notation for expressing properties of the program store. We work in the logical tradition by encoding the programs and partial specifications as formulas in monadic second-order logic. Validity of these formulas is checked by the MONA tool, which also can provide explicit counterexamples to invalid formulas. To make verification decidable, the technique requires explicit loop and function call invariants. In return, the technique is highly modular: every statement of a given program is analyzed only once. The main target applications are safety-critical data-type algorithms, where the cost of annotating a program with invariants is justified by the value of being able to automatically verify complex properties of the program

Time-resolved near-edge X-ray absorption fine structure of pyrazine from electronic structure and nuclear wave packet dynamics simulations

As a demonstration of the analysis of the electronic structure and the nuclear dynamics from time-resolved near-edge X-ray absorption fine structure (TR-NEXAFS), we present the TR-NEXAFS spectra of pyrazine following the excitation to the 1B2u(ππ*) state. The spectra are calculated combining the frozen-core/core-valence separated equation-of-motion coupled cluster singles and doubles approach for the spectral signatures and the multiconfiguration time-dependent Hartree method for the wave packet propagation. The population decay from the 1B2u(ππ*) state to the 1B3u(nπ*) and 1Au(nπ*) states, followed by oscillatory flow of population between the 1B3u(nπ*) and 1Au(nπ*) states, is interpreted by means of visualization of the potential energy curves and the reduced nuclear densities. By examining the electronic structure of the three valence-excited states and the final core-excited states, we observe that the population dynamics is explicitly reflected in the TR-NEXAFS spectra, especially when the heteroatoms are selected as the X-ray absorption sites. This work illustrates the feasibility of extracting fine details of molecular photophysical processes from TR-NEXAFS spectra by using currently available theoretical methods