59 research outputs found
Development of a triple GEM UV-photon detector operated in pure CF4 for the PHENIX experiment
Results obtained with a triple GEM detector operated in pure CF4 with and
without a reflective CsI photocathode are presented. The detector operates in a
stable mode at gains up to 10^4. A deviation from exponential growth starts to
develop when the total charge exceeds ~ 4 10^6 e leading to gain saturation
when the total charge is ~ 2 10^7 e and making the structure relatively robust
against discharges. No aging effects are observed in the GEM foils after a
total accumulated charge of ~ 10 mC/cm^2 at the anode. The ion back-flow
current to the reflective photocathode is comparable to the electron current to
the anode. However, no significant degradation of the CsI photocathode is
observed for a total ion back-flow charge of ~ 7 mC/cm^2.Comment: 14 pages, 11 figures, Submitted to NIM
Use of zinc phosphate cement as a luting agent for Denzir™ copings: an in vitro study
BACKGROUND: The clinical success rate with zinc phosphate cemented Procera crowns is high. The objective with this study was to determine whether CADCAM processed and zinc phosphate cemented Denzir copings would perform as well as zinc phosphate cemented Procera copings when tested in vitro in tension. METHODS: Twelve Procera copings and twenty-four Denzir copings were made. After the copings had been made, twelve of the Denzir copings were sandblasted on their internal surfaces. All copings were then cemented with zinc phosphate cement to carbon steel dies and transferred to water or artificial saliva. Two weeks after cementation, half of the samples were tested. The remaining samples were tested after one year in the storage medium. All tests were done in tension and evaluated with an ANOVA. RESULTS: Sandblasted and un-sandblasted Denzir copings performed as well as Procera copings. Storage in water or artificial saliva up to one year did not decrease the force needed to dislodge any of the coping groups. Three copings fractured during testing and one coping developed a crack during testing. The three complete fractures occurred in Procera copings, while the partly cracked coping was a Denzir coping. CONCLUSION: No significant differences existed between the different material groups, and the retentive force increased rather than decreased with time. Fewer fractures occurred in Denzir copings, explained by the higher fracture toughness of the Denzir material. Based on good clinical results with zinc phosphate cemented Procera crowns, we foresee that zinc phosphate cement luted Denzir copings are likely to perform well clinically
Further progress in ion back-flow reduction with patterned gaseous hole-multipliers
A new idea on electrostatic deviation and capture of back-drifting
avalanche-ions in cascaded gaseous hole-multipliers is presented. It involves a
flipped reversed-bias Micro-Hole & Strip Plate (F-R-MHSP) element, the strips
of which are facing the drift region of the multiplier. The ions, originating
from successive multiplication stages, are efficiently deviated and captured by
such electrode. Experimental results are provided comparing the ion-blocking
capability of the F-R-MHSP to that of the reversed-bias Micro-Hole & Strip
Plate (R-MHSP) and the Gas Electron Multiplier (GEM). Best ion-blocking results
in cascaded hole-multipliers were reached with a detector having the F-R-MHSP
as the first multiplication element. A three-element F-R-MHSP/GEM/MHSP cascaded
multiplier operated in atmospheric-pressure Ar/CH4 (95/5), at total gain of
~10^{5}, yielded ion back-flow fractions of 3*10^{-4} and 1.5*10^{-4}, at drift
fields of 0.5 and 0.2 kV/cm, respectively. We describe the F-R-MHSP concept and
the relevance of the obtained ion back-flow fractions to various applications;
further ideas are also discussed.Comment: 17 pages, 11 figures, published in JINS
Single-UV-photon 2-D imaging with multi-GEM detectors
The main goal being the construction of large-area, low-cost position-sensitive micropattern gaseous photomultipliers (GPMs) based on gas electron multipliers (GEM) cascades, we have studied the single-photon imaging capabilities of a 4-GEM GPM with a reflective CsI-photocathode deposited on the top surface of the 1st GEM. The charge readout was performed with a simple/economic Wedge and Strip (W&S) readout electrode, using pulses induced through a resistive electrode. We have demonstrated the feasibility of single-photon imaging GPM with sub-millimeter resolution; single-photon spatial resolutions as small as ~150Ă‚Â [mu]m (FWHM), i.e. ~65Ă‚Â [mu]m (RMS), were measured in Ar/5%CH4 gas mixture at atmospheric pressure.http://www.sciencedirect.com/science/article/B6TJM-4NS2G9V-M/1/b808ebe094732f4310ee7686c9118a7
Advances in the Micro-Hole & Strip Plate gaseous detector
We report on the performance of a new gaseous electron multiplier: the Micro-Hole & Strip Plate (MHSP). It consists of two independent charge-amplification stages in a single, double-sided micro-structured electrode, deposited on a thin insulating substrate. Charge gains in excess of 103 were obtained in a MHSP operated with soft X-rays in Ar/CO2 (70/30). We present the results of a systematic study of the MHSP properties and those of a double-stage GEM+MHSP multiplier. Applications to gaseous photomultipliers are discussed.http://www.sciencedirect.com/science/article/B6TJM-48GF7W8-1/1/9ca82a7819a2c55a59c29ed0a8803a9
Construction and Performance of a Micro-Pattern Stereo Detector with Two Gas Electron Multipliers
The construction of a micro-pattern gas detector of dimensions 40x10 cm**2 is
described. Two gas electron multiplier foils (GEM) provide the internal
amplification stages. A two-layer readout structure was used, manufactured in
the same technology as the GEM foils. The strips of each layer cross at an
effective crossing angle of 6.7 degrees and have a 406 um pitch. The
performance of the detector has been evaluated in a muon beam at CERN using a
silicon telescope as reference system. The position resolutions of two
orthogonal coordinates are measured to be 50 um and 1 mm, respectively. The
muon detection efficiency for two-dimensional space points reaches 96%.Comment: 21 pages, 17 figure
A concise review on THGEM detectors
We briefly review the concept and properties of the Thick GEM (THGEM); it is
a robust, high-gain gaseous electron multiplier, manufactured economically by
standard printed-circuit drilling and etching technology. Its operation and
structure resemble that of GEMs but with 5 to 20-fold expanded dimensions. The
millimeter-scale hole-size results in good electron transport and in large
avalanche-multiplication factors, e.g. reaching 10^7 in double-THGEM cascaded
single-photoelectron detectors. The multiplier's material, parameters and shape
can be application-tailored; it can operate practically in any counting gas,
including noble gases, over a pressure range spanning from 1 mbar to several
bars; its operation at cryogenic (LAr) conditions was recently demonstrated.
The high gain, sub-millimeter spatial resolution, high counting-rate
capability, good timing properties and the possibility of industrial production
capability of large-area robust detectors, pave ways towards a broad spectrum
of potential applications; some are discussed here in brief.Comment: 8 pages, 11 figures; Invited Review at INSTR08, Novosibirsk, Feb
28-March 5 200
Development of high-gain gaseous photomultipliers for the visible spectral range
We summarize the development of visible-sensitive gaseous photomultipliers,
combining a semitransparent bi-alkali photocathode with a state-of-the-art
cascaded electron multiplier. The latter has high photoelectron collection
efficiency and a record ion blocking capability. We describe in details the
system and methods of photocathode production and characterization, their
coupling with the electron multiplier and the gaseous-photomultiplier operation
and characterization in a continuous mode. We present results on the properties
of laboratory-produced KCsSb, CsSb and NaKSb photocathodes and
report on their stability and QE in gas; KCsSb photocathodes yielded QE
values in Ar/CH(95/5) above 30% at wavelengths of 360-400 nm. The novel
gaseous photomultiplier yielded stable operation at gains of 10, in
continuous operation mode, in 700 Torr of this gas; its sensitivity to single
photons was demonstrated. Other properties are described. The successful
detection of visible light with this gas-photomultiplier pave ways towards
further development of large-area sealed imaging detectors, of flat geometry,
insensitive to magnetic fields, which might have significant impact on light
detection in numerous fields.Comment: 22 pages, 12 figures, for submission to JINS
Blood flow changes using a 3D xenogeneic collagen matrix or a subepithelial connective tissue graft for root coverage procedures: a pilot study.
BACKGROUND: The study investigated the early healing process following the treatment of single Miller class I and II recessions with a 3D xenogeneic collagen matrix (CMX) or connective tissue graft (CTG). METHODS: This pilot investigation was designed as a single-center randomized controlled parallel trial. A total of eight subjects (four per group) were treated with either CMX or CTG in the anterior maxilla. Vascular flow changes were assessed by laser Doppler flowmetry (LDF) before and after surgery and at days 1, 2, 3, 7, 14, and 30 while clinical evaluations took place at baseline and at days 60 and 180. Pain intensity perception was evaluated by the short-form McGill pain questionnaire (SF-MPQ), at days 1 and 14. RESULTS: The vascular flow fluctuated similarly in both groups pre- and post-operatively, but the CTG exhibited a more homogeneous pattern as opposed to CMX that showed a second phase of increased blood flow at 14Â days. Clinically, the CTG led to greater change in mean root coverage and keratinized tissue gain but CMX was associated with lower early pain intensity scores. CONCLUSIONS: Within the limits of the study, the vascular flow alterations during the early healing of both graft types followed a similar pattern. The CMX was associated with a second peak of increased blood flow. CLINICAL RELEVANCE: The vascular flow changes after the application of CMX for single tooth recession root coverage did not show major differences from those observed after the use of a CTG. A trend for better clinical performance in terms of root coverage and keratinized tissue gain was noted for the CTG, but the initial patient morbidity was less for CMX
PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS
Only a small percentage of individuals living in endemic areas develop severe malaria suggesting that host genetic factors may play a key role. This study has determined the frequency of single nucleotide polymorphisms (SNPs) in some pro and anti-inflammatory cytokine gene sequences: IL6 (-174; rs1800795), IL12p40 (+1188; rs3212227), IL4 (+33; rs2070874), IL10 (-3575; rs1800890) and TGFb1 (+869; rs1800470), by means of PCR-RFLP. Blood samples were collected from 104 symptomatic and 37 asymptomatic subjects. Laboratory diagnosis was assessed by the thick blood smear test and nested-PCR. No association was found between IL6 (-174), IL12p40 (+1188), IL4 (+33), IL10 (- 3575), TGFb1 (+869) SNPs and malaria symptoms. However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic allele A, in the symptomatic group (c2 = 4.54, p = 0.01, OR = 0.40 [95% CI - 0.17- 0.94]). When the analysis was performed by allele, the frequency of the polymorphic allele A was also significantly higher in the symptomatic group (c2 = 4.50, p = 0.01, OR = 0.45 [95% CI - 0.21-0.95]). In conclusion, this study has suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance of malaria symptoms in individuals living in endemic areas. Taking into account that this polymorphism is related to decreased IL10 production, a possible role of this SNP in the pathophysiology of malaria is also suggested, but replication studies with a higher number of patients and evaluation of IL10 levels are needed for confirmation
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