Neoadjuvant endocrine therapy for luminal breast cancer treatment: a first-choice alternative in times of crisis such as the COVID-19 pandemic

The epidemiological emergency caused by CoV-2 (COVID-19) has changed priorities in breast cancer management. In those places where the pandemic has had the greatest effect, it is of paramount importance for most patients to be at home, reducing or postponing their attendance at clinics, as well as avoiding surgeries. In this scenario, neoadjuvant endocrine treatment could be an appropriate alternative treatment for hormone receptor positive breast cancer (luminal-like tumours) in order to minimise hospital admissions and to delay elective surgeries. Accordingly, we present a simple protocol that can be applied to most cases of luminal-like breast cancer and is appropriate for the majority of secondary or tertiary medical centres, or even primary car

Random Surfaces that Suppress Single Scattering

We present a method for generating numerically a one-dimensional random surface, defined by the equation x_3 = \zx, that suppresses single-scattering processes in the scattering of light from it within a specified range of scattering angles. Rigorous numerical calculations of the scattering of light from surfaces generated by this approach show that the single-scattering contribution to the mean scattered intensity is indeed suppressed within that range of angles.Comment: 3 pagers (Latex), 3 figure

A tabu search heuristic for the Equitable Coloring Problem

The Equitable Coloring Problem is a variant of the Graph Coloring Problem where the sizes of two arbitrary color classes differ in at most one unit. This additional condition, called equity constraints, arises naturally in several applications. Due to the hardness of the problem, current exact algorithms can not solve large-sized instances. Such instances must be addressed only via heuristic methods. In this paper we present a tabu search heuristic for the Equitable Coloring Problem. This algorithm is an adaptation of the dynamic TabuCol version of Galinier and Hao. In order to satisfy equity constraints, new local search criteria are given. Computational experiments are carried out in order to find the best combination of parameters involved in the dynamic tenure of the heuristic. Finally, we show the good performance of our heuristic over known benchmark instances

Design of one-dimensional Lambertian diffusers of light

We describe a method for designing a one-dimensional random surface that acts as a Lambertian diffuser. The method is tested by means of rigorous computer simulations and is shown to yield the desired scattering pattern.Comment: 6 pages, 2 figure