The Size of a Graph Without Topological Complete Subgraphs

In this note we show a new upperbound for the function ex(n;TKp), i.e., the maximum number of edges of a graph of order n not containing a subgraph homeomorphic to the complete graph of order p. Further, for ${\left \lceil \frac{2n+5}{3}\right \rceil}\leq p < n$ we provide exact values for this function

Extremal Graphs without Topological Complete Subgraphs

The exact values of the function $ex(n;TK_{p})$ are known for ${\lceil \frac{2n+5}{3}\rceil}\leq p < n$ (see [Cera, Diánez, and Márquez, SIAM J. Discrete Math., 13 (2000), pp. 295--301]), where $ex(n;TK_p)$ is the maximum number of edges of a graph of order n not containing a subgraph homeomorphic to the complete graph of order $p.$ In this paper, for ${\lceil \frac{2n+6}{3} \rceil}\leq p < n - 3,$ we characterize the family of extremal graphs $EX(n;TK_{p}),$ i.e., the family of graphs with n vertices and $ex(n;TK_{p})$ edges not containing a subgraph homeomorphic to the complete graph of order $p.

IgA Vasculitis: Influence of CD40, BLK and BANK1 Gene Polymorphisms

CD40, BLK and BANK1 genes involved in the development and signaling of B-cells are identified as susceptibility loci for numerous inflammatory diseases. Accordingly, we assessed the potential influence of CD40, BLK and BANK1 on the pathogenesis of immunoglobulin-A vasculitis (IgAV), predominantly a B-lymphocyte inflammatory condition. Three genetic variants within CD40 (rs1883832, rs1535045, rs4813003) and BLK (rs2254546, rs2736340, rs2618476) as well as two BANK1 polymorphisms (rs10516487, rs3733197), previously associated with inflammatory diseases, were genotyped in 382 Caucasian patients with IgAV and 955 sex- and ethnically matched healthy controls. No statistically significant differences were observed in the genotype and allele frequencies of CD40, BLK and BANK1 when IgAV patients and healthy controls were compared. Similar results were found when CD40, BLK and BANK1 genotypes or alleles frequencies were compared between patients with IgAV stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations. Moreover, no CD40, BLK and BANK1 haplotype differences were disclosed between patients with IgAV and healthy controls and between patients with IgAV stratified according to the clinical characteristics mentioned above. Our findings indicate that CD40, BLK and BANK1 do not contribute to the genetic background of IgAV.European CommissionInstituto de Salud Carlos III" (ISCIII, Health Ministry, Spain) PI18/00042 PI21/00042 Instituto de Salud Carlos IIIEuropean Social Fund (ESF) CM20/00006RICORS Program from ISCIIIEuropean Commission RD21/0002/0025RETICS Program (ISCIII) RD16/0012/0009RETICS Program (European Regional Development Fund (ERDF) RD16/0012/0009European Union FEDER fund RD16/0012/0014 PI17/00409Research Executive Agency (REA) of the European Union 734899Miguel Servet type II program fellowship from the ISCIIIESF ("Investing in your future") CPII21/0000

Mobile devices as assistive technologies for ASD: experiences in the classroom

This is a post-peer-review, pre-copyedit version of an article published in Lecture Notes in Computer Science. The final authenticated version is available online at https://doi.org/10.1007/978-3-319-40355-7_18Information and Communication Technologies offer new opportunities to people with disabilities to develop their autonomy and independence in their daily life activities. However, more research should be done in order to comprehend how technology affects this collective of people. This paper presents two experiences where participants with cognitive disabilities and Autism Spectrum Disorder used AssisT-Task to perform job related activities and DEDOS to perform educational activities. Their performance is improved along the sessions using both tools. Combining visual and textual information help students with cognitive disabilities and ASD to focus on the contents presented, avoiding usability and accessibility issues, and therefore improving their learning process while they are having fun interacting with new technologiesThis work has been funded in part by the Spanish Economy and Competitiveness Ministry under project “e-Integra: e-Training y e-Coaching para la integración socio-laboral” (TIN2013-44586-R) and by the Region of Madrid under pro-ject “eMadrid – Investigación y Desarrollo de tecnologías para el e-learning en la Comunidad de Madrid (S2013/ICE-2715

Transient Mesenteric Ischemia Leads to Remodeling of Rat Mesenteric Resistance Arteries

Mesenteric ischemia/reperfusion (I/R) is associated with high rates of morbidity and mortality. We studied the effect of mesenteric I/R on structural and mechanical properties of rat mesenteric resistance artery (MRA) that, once disrupted, might impact the outcome of this devastating clinical condition. Superior mesenteric artery from Wistar–Kyoto rats was occluded (90 min) and reperfused (24 h). The effect of tezosentan, a dual endothelin (ET)-receptor antagonist, was studied in ischemic (IO) and sham-operated (SO) animals. MRA structure and mechanics were assessed by pressure myography. Nuclei distribution, elastin content and organization, collagen I/III and ET-1 expression, ET-1 plasma levels, superoxide anion (O2⋅−) production, and mRNA levels of NAD(P)H-oxidase subunits were measured. To assess ET-1 effects on O2⋅− production, MRA from non-operated rats were incubated in culture medium with ET-1. Mesenteric I/R increased MRA wall thickness (P < 0.05) and cross-sectional area (P < 0.05) but decreased wall stiffness (P < 0.05). Arterial remodeling was paralleled by enhancement of: (i) collagen I/III expression (P < 0.01), ET-1 expression (P < 0.05), and O2⋅− formation (P < 0.01) in the vessel wall; (ii) number of internal elastic lamina (IEL) fenestrae (P < 0.05); and (iii) plasma levels of ET-1 (P < 0.05). Moreover, ET-1 increased O2⋅− (P < 0.05) production in cultured MRA. Tezosentan prevented hypertrophic remodeling and collagen I/III deposition, and enhanced O2⋅− production, but it did not affect the decreased wall stiffness after mesenteric I/R. These results indicate that 90 min occlusion/24 h reperfusion induces hypertrophic remodeling of MRA linked to ET-1-mediated increase of collagen and O2⋅−. Decreased stiffness may be associated with increased number of IEL fenestrae. The resulting MRA remodeling, initially adaptive, might become maladaptive contributing to the pathology and poor outcome of mesenteric I/R, and might be a valuable treatment target for mesenteric I/R

Effect of long-chain fatty alcohols from orujo olive oil on nitric oxide and eicosanoid generation

1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, SpainOlive pomace oil (‘orujo’ oil) is an olive oil product suitable for human consumption that is traditionally produced in Spain(1). The non-acylglycerol component of this oil is a good source of interesting minor components, e.g. triterpenes(2), or fatty alcohols, derived from waxy materials.This study is part of the project AGL2005–00572/ALI, financially supported by the Comision Interministerial de Ciencia y Tecnologia (CICYT).Peer reviewe

Infiltration of abdominal striae distensae by Hodgkin's lymphoma

Cutaneous Hodgkin’s lymphoma (HL) is generally secondary to dissemination from a nodal HL; it tends to occur late in thecourse of the disease, and is associated with a poor progno-sis. It often manifests first as painless erythematous nodules and papules in the chest area. Primary cutaneous HL is extremely uncommon

Emotional Effects of the Duration, Efficiency, and Subjective Quality of Sleep in Healthcare Personnel

Considering that both sleep quality and duration are linked to psychological variables, this study analyzed the relationships between sleep components and emotional intelligence and the effects that sleep duration has on stress management and mood in a sample of nurses. The sample was made up of 1073 professionals. Data were collected by the Pittsburgh Sleep Quality Index and the Brief Emotional Intelligence Inventory for Senior Citizens. The results showed that the components of sleep quality were negatively related to stress management and mood. Furthermore, nurses who had short sleep patterns also had low moods and high stress levels. This study emphasizes the importance of subjective sleep quality as a necessary resource for professionals to manage stressful situations and mood and improve their relations with their patients and with each other