High-Precision Entropy Values for Spanning Trees in Lattices

Shrock and Wu have given numerical values for the exponential growth rate of the number of spanning trees in Euclidean lattices. We give a new technique for numerical evaluation that gives much more precise values, together with rigorous bounds on the accuracy. In particular, the new values resolve one of their questions.Comment: 7 pages. Revision mentions alternative approach. Title changed slightly. 2nd revision corrects first displayed equatio

Kinetics and Inhibition Studies of the L205R Mutant of cAMP-Dependent Protein Kinase Involved in Cushing’s Syndrome

Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing\u27s syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) in adrenal adenomas of patients with adrenocorticotropic hormone‐independent Cushing\u27s syndrome. Here, we conducted kinetics and inhibition studies on the L205R‐PKACα mutant. We have found that the L205R mutation affects the kinetics of both Kemptide and ATP as substrates, decreasing the catalytic efficiency (kcat/KM) for each substrate by 12‐fold and 4.5‐fold, respectively. We have also determined the IC50 and Ki for the peptide substrate‐competitive inhibitor PKI(5–24) and the ATP‐competitive inhibitor H89. The L205R mutation had no effect on the potency of H89, but causes a \u3e 250‐fold loss in potency for PKI(5–24). Collectively, these data provide insights for the development of L205R‐PKACα inhibitors as potential therapeutics

What is past is prologue: Pre-natal testosterone and parental bonding predicts adult attachment styles

Research consistently evidences deleterious consequences of poor parenting in the development of dysfunctional and antisocial behaviours in children (Jaffee et al., 2005). For example, foetal development is affected by the psychological and physical health of the mother. Indeed, maternal smoking increases in utero testosterone (Rizwan et al., 2007), which is associated with aggression (Bailey & Hurd, 2005), risk-taking (Stenstrom et al., 2010) and dom- inant (Millet, 2011) behaviours. However, interactions such as these may offer survival advantage to offspring within hostile environments (Belsky, Steinberg & Draper, 1991). We investigated relationships between prenatal testosterone (2D:4D ratio), perception of quality of parental bonding and adult attachment style. As expected, low maternal warmth and high levels of prenatal testosterone predicted anxious attachment, while the addition of maternal over-controlling to this model predicted avoidant attachment. This evidences how changes in hormonal level might equip an unborn child to survive more successfully within a prospective adversarial environment

Microwave properties of DyBa_2Cu_3O_(7-x) monodomains and related compounds in magnetic fields

We present a microwave characterization of a DyBa$_{2}$Cu$_{3}$O$_{7-x}$ single domain, grown by the top-seeded melt-textured technique. We report the (a,b) plane field-induced surface resistance, $\Delta R_s(H)$, at 48.3 GHz, measured by means of a cylindrical metal cavity in the end-wall-replacement configuration. Changes in the cavity quality factor Q against the applied magnetic field yield $\Delta R_s(H)$ at fixed temperatures. The temperature range [70 K ; T_c] was explored. The magnetic field $\mu_0 H <$ 0.8 T was applied along the c axis. The field dependence of $\Delta R_s(H)$ does not exhibit the steep, step-like increase at low fields typical of weak-links. This result indicates the single-domain character of the sample under investigation. $\Delta R_s(H)$ exhibits a nearly square-root dependence on H, as expected for fluxon motion. From the analysis of the data in terms of motion of Abrikosov vortices we estimate the temperature dependences of the London penetration depth $\lambda$ and the vortex viscosity $\eta$, and their zero-temperature values $\lambda(0)=$165 nm and $\eta(0)=$ 3 10$^{-7}$ Nsm$^{-2}$, which are found in excellent agreement with reported data in YBa$_{2}$Cu$_{3}$O$_{7-x}$ single crystals. Comparison of microwave properties with those of related samples indicate the need for reporting data as a function of T/T_c in order to obtain universal laws.Comment: 6 pages, 4 figures, LaTeX, submitted to Journal of Applied Physic

Mine is Bigger than Yours! Narcissism Predicts Biases in Perceived Head Size

The expression big headed is often used to describe narcissists, however is it possible that this term signals a bias in how narcissists perceive themselves? We tested whether narcissistic traits predicted biases in the estimated size and weight of specific body parts, including head circumference and brain weight. In two questionnaire-based studies, participants estimated the size or weight of parts of their body. In Study 1 (n = 316), we found that the Leadership/Authority facet of narcissism significantly predicted greater estimates of head circumference in men, but lower estimates of head circumference in women. In Study 2 (n = 275), we found that when a sex-specific average head circumference was not provided, Leadership/Authority predicted greater estimates of head circumference overall. We present evidence that narcissism predicts biases in estimated head size and brain weight, but that the precise nature of these biases is dependent on the provided frame of reference for body size. These results are discussed with reference to within-sex competitive strategies, perceived intelligence and stereotypes for male and female attractiveness

One Wonderful Night

https://digitalcommons.library.umaine.edu/mmb-vp/3695/thumbnail.jp