Three year follow-up of an early childhood intervention : is movement skill sustained?

BackgroundMovement skill competence (e.g. the ability to throw, run and kick) is a potentially important physical activity determinant. However, little is known about the long-term impact of interventions to improve movement skills in early childhood. This study aimed to determine whether intervention preschool children were still more skill proficient than controls three years after a 10 month movement skill focused intervention: &lsquo;Tooty Fruity Vegie in Preschools&rsquo;.MethodsChildren from 18 intervention and 13 control preschools in NSW, Australia were assessed at ages four (Time1), five (T2) and eight years (T3) for locomotor (run, gallop, hop, leap, horizontal jump, slide) and object control proficiency (strike, bounce, catch, kick, overhand throw, underhand roll) using the Test of Gross Motor Development-2. Multi-level object control and locomotor regression models were fitted with variables time, intervention (yes/no) and a time*intervention interaction. Both models added sex of child and retained if significant, in which case interactions of sex of child with other variables were modelled and retained. SPSS (Version 17.0) was used.ResultsOverall follow-up rate was 29% (163/560). Of the 137 students used in the regression models, 53% were female (n = 73). Intervention girls maintained their object control skill advantage in comparison to controls at T3 (p = .002), but intervention boys did not (p = .591). At T3, there were no longer intervention/control differences in locomotor skill (p = .801).ConclusionEarly childhood settings should implement movement skill interventions and more intensively target girls and object control skills.<br /

Layering methodological tools to represent classroom collectivity

Our research is guided by the question: “How might we observe, document, display, and analyze data from a collective systems perspective?” In this research forum, we share new research tools for studying mathematics classrooms, highlight opportunities for observation and analysis by layering these tools, and then illustrate how the layering of tools allows for visual distinctions across lessons and classrooms.Research was supported by the Social Sciences and Humanities Research Council of Canada

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations

Objective: To investigate mitophagy in 5 patients with severe dominantly inherited optic atrophy (DOA), caused by depletion of OPA1 (a protein that is essential for mitochondrial fusion), compared with healthy controls. Methods: Patients with severe DOA (DOA plus) had peripheral neuropathy, cognitive regression, and epilepsy in addition to loss of vision. We quantified mitophagy in dermal fibroblasts, using 2 high throughput imaging systems, by visualizing colocalization of mitochondrial fragments with engulfing autophagosomes. Results: Fibroblasts from 3 biallelic OPA1(2/2) patients with severe DOA had increased mitochondrial fragmentation and mitochondrial DNA (mtDNA)–depleted cells due to decreased levels of OPA1 protein. Similarly, in siRNA-treated control fibroblasts, profound OPA1 knockdown caused mitochondrial fragmentation, loss of mtDNA, impaired mitochondrial function, and mitochondrial mislocalization. Compared to controls, basal mitophagy (abundance of autophagosomes colocalizing with mitochondria) was increased in (1) biallelic patients, (2) monoallelic patients with DOA plus, and (3) OPA1 siRNA–treated control cultures. Mitophagic flux was also increased. Genetic knockdown of the mitophagy protein ATG7 confirmed this by eliminating differences between patient and control fibroblasts. Conclusions: We demonstrated increased mitophagy and excessive mitochondrial fragmentation in primary human cultures associated with DOA plus due to biallelic OPA1 mutations. We previously found that increased mitophagy (mitochondrial recycling) was associated with visual loss in another mitochondrial optic neuropathy, Leber hereditary optic neuropathy (LHON). Combined with our LHON findings, this implicates excessive mitochondrial fragmentation, dysregulated mitophagy, and impaired response to energetic stress in the pathogenesis of mitochondrial optic neuropathies, potentially linked with mitochondrial mislocalization and mtDNA depletion

What contributes to positive feelings towards mathematics? Examining mathematics autobiographies

In this paper, we present how the participants in our study (post-secondary students) described what contributed to fostering their positive feelings towards mathematics. Drawing from mathematics autobiographies completed by the participants, we present some of the contexts wherein participants described positive feelings toward mathematics. We discuss a) encounters with teacher dispositions and pedagogical practices, b) experiencing the joy of engaging in mathematics, and c) external validation from teachers and parents, and consider whether each of these contexts sustained participants’ positive feelings towards mathematics.SSHRCYe

Images of mathematics learning revealed through students’ experiences of collaboration

This study focuses on students’ images of mathematics learning and their relationships with mathematics. In this paper we consider how students described collaboration in mathematics classrooms, through the examination of students’ autobiographical interviews and drawings. Our analysis revealed that many students considered mathematics learning mainly as an individualized and isolated process and did not perceive peer talk or collective exploration as meaningful. Our cross-analysis with students’ feelings revealed that those who had positive feelings towards mathematics tended to find group work less helpful. Our findings illuminate a perceived gap between teachers’ widespread use of group work as a teaching strategy and students’ understanding and appreciation of the goals of such instruction.YesSSHR

The clinical effectiveness of a cognitive behavioural therapy intervention in a work setting: a 5-year retrospective analysis of outcomes

Background: The National Institute for Health and Clinical Excellence (NICE) guidance recommends Cognitive Behavioural Therapy (CBT) as part of multidisciplinary occupational mental health interventions for people with long-term or recurrent short-term sickness absence from work (NICE, 2009). Despite this, there is a paucity of data for both randomised trials for CBT and literature that supports the transferability of CBT into occupational environments. Aims: This service evaluation aimed to evaluate the clinical effectiveness of CBT by analysing data from a partnership scheme between a local authority and a local heath board using a routine employee population. Methods: A clinical cohort of 81 employees referred through the partnership scheme completed CBT over a 5-year period via a CBT nurse therapist. A sample of 76 employees was included in the evaluation who completed pre-/post-measures to establish outcome. Of these, 30 were followed up at a 3-year point, completing the same measures. Results: Each of the clinical measures yielded significant outcomes at 95% confidence intervals, and large effect sizes using Cohen\u27s d both at post-test and follow-up. No significant difference was shown between post-treatment and follow-up outcomes. CBT was demonstrated to be clinically effective within an occupational mental health setting. Conclusions: In conclusion, partnership schemes with a focus on mental health between public sector agencies can have a positive outcome for the funding agency as well as individual employees. Keywords: CBT nurse therapist; cognitive behavioural therapy (CBT); occupational mental health; partnership schemes; workplace intervention