Cowboy City: An Original Children’s Book

Cowboy City is an original children’s book written for eight to ten year olds that touches on themes of race and representation. Too often the stories of Black cowboys go untold. The book was created to provide children with an accurate portrayal of who the cowboys of the Wild West were, as well as who they are now, while also providing teachers with a tool to introduce the concepts of racial representation throughout history. Told through the voice of nine-year-old Jayden, an African American boy living in the city, Cowboy City follows Jayden’s normal school day, interrupted by an extraordinary event. Throughout the book Jayden experiences the cognitive dissonance that accompanies a mismatch between the learning in the classroom and a students’ racial and cultural identity. Jayden is taught about the rich history of black cowboys, present and past, from his grandfather, yet in his classroom his teacher omits it. After the momentous event, that Jayden witnesses, both he and his teacher are transformed. This independent study includes a rationale that explains my inspiration for writing this particular children’s book, a literature review which provides an overview of the children’s books that I used to research the topics included in the book and as guidance for my own writing, an overview of the developmental milestones of the nine and ten year olds which are aligned with the themes, plot and vocabulary encountered in Cowboy City, the original text and three illustrations, an application section that explains the results of my reading the book with a small group of third graders and the practical applications of the book in a classroom setting and finally a bibliography that cites all of the books utilized in the writing of this thesis

Women\u27s Quest to Occupy Executive Positions in Corporate America

Women comprise 50.8% of the United States population and 47% of the workforce, and over the past few decades, many women have been promoted to midmanagement positions in Fortune 500 and other major corporations, but few run companies at the executive levels. The research problem addressed the underrepresentation of women in top leadership positions in the executive suite. The purpose of this study was to explore the perceptions of women in upper level management in large corporations on rising to the C-suite. A basic qualitative naturalistic inquiry was used employing interviews in collecting and analyzing the data. The targeted population was 15 women in senior positions between the ages of 25 and 60, who have worked for a company with a minimum of 5 years\u27 experience. Introductions by friends and snowballing sampling were used to select 15 participants for the semistructured interviews. The results of the interviews were analyzed through the completion of a content analysis obtained through coding to allow for the identification of emergent themes. Key findings indicated the emergence of the following themes: loss of confidence, mentoring, sponsoring, and diversity. The study was socially significant in that it provided information for policy changes, access to sponsorship and mentorship programs, and promotion of social change in relation to gender equality in the workplace

With mouse age comes wisdom : a review and suggestions of relevant mouse models for age-related conditions

Ageing is a complex multifactorial process that results in many changes in physiological changes processes that ultimately increase susceptibility to a wide range of diseases. As such an ageing population is resulting in a pressing need for more and improved treatments across an assortment of diseases. Such treatments can come from a better understanding of the pathogenic pathways which, in turn, can be derived from models of disease. Therefore the more closely the model resembles the disease situation the more likely relevant the data will be that is generated from them. Here we review the state of knowledge of mouse models of a range of diseases and aspects of an ageing physiology that are all germane to ageing. We also give recommendations on the most common mouse models on their relevance to the clinical situations occurring in aged patients and look forward as to how research in ageing models can be carried out. As we continue to elucidate the pathophysiology of disease, often through mouse models, we also learn what is needed to refine these models. Such factors can include better models, reflecting the ageing patient population, or a better phenotypic understanding of existing models

Stevens-Johnson Syndrome and Herpes Simplex Type 1 Infection during Adalimumab Therapy for Crohn's Disease

Stevens–Johnson syndrome (SJS) is a severe mucocutaneous adverse drug reaction with a relatively high mortality rate. SJS is described during herpes simplex virus type 1 (HSV1) infection and, rarely, even during adalimumab therapy. We report the case of a patient with Crohn’s disease who developed SJS during an HSV1 infection and a contemporaneous anti-TNFα therapy with adalimumab. Remission was achieved with suspension of adalimumab and high doses of intravenous steroids and antivirals. Patients with HSV1 infection and on adalimumab therapy have a combined risk of SJS and should be monitored closely

Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2021

The 9th biennial conference titled “Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases” was hosted virtually, due to the ongoing COVID-19 pandemic, in collaboration with the University of Vermont Larner College of Medicine, the National Heart, Lung, and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, and the International Society for Cell & Gene Therapy. The event was held from July 12th through 15th, 2021 with a pre-conference workshop held on July 9th. As in previous years, the objectives remained to review and discuss the status of active research areas involving stem cells (SCs), cellular therapeutics, and bioengineering as they relate to the human lung. Topics included 1) technological advancements in the in situ analysis of lung tissues, 2) new insights into stem cell signaling and plasticity in lung remodeling and regeneration, 3) the impact of extracellular matrix in stem cell regulation and airway engineering in lung regeneration, 4) differentiating and delivering stem cell therapeutics to the lung, 5) regeneration in response to viral infection, and 6) ethical development of cell-based treatments for lung diseases. This selection of topics represents some of the most dynamic and current research areas in lung biology

Genomic Transition to Pathogenicity in Chytrid Fungi

Understanding the molecular mechanisms of pathogen emergence is central to mitigating the impacts of novel infectious disease agents. The chytrid fungus Batrachochytrium dendrobatidis (Bd) is an emerging pathogen of amphibians that has been implicated in amphibian declines worldwide. Bd is the only member of its clade known to attack vertebrates. However, little is known about the molecular determinants of - or evolutionary transition to - pathogenicity in Bd. Here we sequence the genome of Bd's closest known relative - a non-pathogenic chytrid Homolaphlyctis polyrhiza (Hp). We first describe the genome of Hp, which is comparable to other chytrid genomes in size and number of predicted proteins. We then compare the genomes of Hp, Bd, and 19 additional fungal genomes to identify unique or recent evolutionary elements in the Bd genome. We identified 1,974 Bd-specific genes, a gene set that is enriched for protease, lipase, and microbial effector Gene Ontology terms. We describe significant lineage-specific expansions in three Bd protease families (metallo-, serine-type, and aspartyl proteases). We show that these protease gene family expansions occurred after the divergence of Bd and Hp from their common ancestor and thus are localized to the Bd branch. Finally, we demonstrate that the timing of the protease gene family expansions predates the emergence of Bd as a globally important amphibian pathogen

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages