Teaching ethics: a case study-based, interdisciplinary framework

As economies in the MENA region have become increasingly global and dependent on foreign labour, higher education institutions have a responsibility to effectively incorporate ethics education. This article presents a new interdisciplinary, case study-based model for teaching ethics in higher education (ICE model). It is comprised of five components including: 1) a discussion to identify the ethical dilemma involved; 2) an examination of the consequences of an action on self and others; 3) an examination of how the environment may affect moral reasoning; 4) a discussion of how and why decision-making may change when certain details or circumstances in the dilemma are changed; 5) a summary of one\u27s final decision with its justification

Nurses\u27 Alumnae Association Bulletin - Volume 2 Number 3

The Jefferson Nurse Letter from the President Delegates to Biennial Convention Attention Blood Transfusion - Plasma Unit Life in the Army Nurse Corps Secretary\u27s Report Elected to New Office 1892-1942 Progress or Alumnae Association 1892-1942 Report of the School of Nursing Staff News Please Change My Address Air Cooled Red Cross Report Fingerprinting Graduates in the U.S. Army and Navy Degrees Received Promotions Jubilee Report Engagements Marriages Births New Positions - 1941-1942 New Positions on the Nursing Staff of the Hospita

The pre-atmospheric hydrogen inventory of CM carbonaceous chondrites

Understanding the quantity and isotopic composition of water that has been delivered to Earth over its history is crucial for models our planet’s evolution, and predicting habitability across the solar system. Here we have used stepwise pyrolysis to measure the hydrogen inventory of CM carbonaceous chondrites, which are likely to have been a major source of volatiles for the early Earth. Stepwise pyrolysis potentially enables the carriers of pre-terrestrial hydrogen to be identified, and distinguished from hydrogen that may have been added during the meteorite’s time on Earth. Twelve CM meteorites were analysed, and from their bulk hydrogen composition, petrologic type and nature of parent body processing, they can be divided into three subsets. The CMs of subset A have been mildly aqueously altered. Their hydrogen is hosted by isotopically light phyllosilicate, isotopically heavy organic matter, and adsorbed terrestrial water that is comparable to or slightly heavier than phyllosilicate. The subset B meteorites have been heavily aqueously altered and their hydrogen is also in phyllosilicate, organic matter and adsorbed terrestrial water. Their pyrolysis profiles differ from subset A in that the phyllosilicates dehydroxylate at higher temperatures owing to differences in mineralogy and chemical composition. The hydrogen that was evolved from organic matter may also have been isotopically lighter owing to loss of deuterium during aqueous alteration. Subset C meteorites were heated on their parent body after aqueous alteration, leading to loss of hydrogen from phyllosilicates and organic matter such that half of the water that they evolve was added after falling to Earth. Taking the 12 CMs together, an average of 0.20 wt. % H (21 % of total H) is terrestrial, and recalculation of bulk compositions without this component can raise bulk δD of individual meteorites by up to 73 ‰. Carbonaceous chondrites in our collections differ in the abundance and isotopic composition of hydrogen relative to their parent asteroid(s). An accurate understanding of the nature of water that was delivered to early Earth can only come from the analysis of materials that have been isolated from the terrestrial atmosphere, such as those returned from Ryugu and Bennu

Positive airway pressure longer than 24 h is associated with histopathological volutrauma in severe COVID-19 pneumonia—an ESGFOR based narrative case-control review

SARS-CoV-2; Post-mortem microbiology; VolutraumaSARS-CoV-2; Microbiología post mortem; VolutraumaSARS-CoV-2; Microbiologia post mortem; VolutraumaBackground and Objective: A thorough understanding of the pathogenic mechanisms elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still requires further research. Until recently, only a restricted number of autopsies have been performed, therefore limiting the accurate knowledge of the lung injury associated with SARS-CoV-2. A multidisciplinary European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group of Forensic and Post-mortem Microbiology-ESGFOR team conducted a non-systematic narrative literature review among coronavirus 2019 disease (COVID-19) pneumonia cases assessing the histopathological (HP) effects of positive airways pressure. HP lung features were recorded and compared between mechanically ventilated (>24 hours) and control (ventilation <24 hours) patients. A logistic regression analysis was performed to identify associations between mechanical ventilation (MV) and HP findings. Methods: A PubMed and MEDLINE search was conducted in order to identify studies published between March 1st 2020 and June 30th 2021. Key Content and Findings: Seventy patients (median age: 69 years) from 24 studies were analysed, among whom 38 (54.2%) underwent MV longer than 24 hours. Overall, main HP features were: diffuse alveolar damage (DAD) in 53 (75.7%), fibrosis (interstitial/intra-alveolar) in 43 (61.4%), vascular damage—including thrombosis/emboli- in 41 (58.5%), and endotheliitis in only 8 (11.4%) patients. Association of DAD, fibrosis and vascular damage was detected in 30 (42.8%) patients. Multivariate analysis, adjusted by age and gender, identified MV >24 hours as an independent variable associated with DAD (OR =5.40, 95% CI: 1.48–19.62), fibrosis (OR =3.88, 95% CI: 1.25–12.08), vascular damage (OR =5.49, 95% CI: 1.78–16.95) and association of DAD plus fibrosis plus vascular damage (OR =6.99, 95% CI: 2.04–23.97). Conclusions: We identified that patients mechanically ventilated >24 hours had a significantly higher rate of pulmonary injury on histopathology independently of age and gender. Our findings emphasize the importance of maintaining a protective ventilator strategy when subjects with COVID-19 pneumonia undergo intubation

Autism screening at 18 months of age: a comparison of the Q-CHAT-10 and M-CHAT screeners.

Funder: Peterborough NHS Foundation TrustFunder: Collaboration for Leadership in Applied Health Research and Care - Greater ManchesterFunder: NIHR Cambridge Biomedical Research CentreBACKGROUND: Autism screening is recommended at 18- and 24-month pediatric well visits. The Modified Checklist for Autism in Toddlers-Revised (M-CHAT-R) authors recommend a follow-up interview (M-CHAT-R/F) when positive. M-CHAT-R/F may be less accurate for 18-month-olds than 24-month-olds and accuracy for identification prior to two years is not known in samples that include children screening negative. Since autism symptoms may emerge gradually, ordinally scoring items based on the full range of response options, such as in the 10-item version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10), might better capture autism signs than the dichotomous (i.e., yes/no) items in M-CHAT-R or the pass/fail scoring of Q-CHAT-10 items. The aims of this study were to determine and compare the accuracy of the M-CHAT-R/F and the Q-CHAT-10 and to describe the accuracy of the ordinally scored Q-CHAT-10 (Q-CHAT-10-O) for predicting autism in a sample of children who were screened at 18 months. METHODS: This is a community pediatrics validation study with screen positive (n = 167) and age- and practice-matched screen negative children (n = 241) recruited for diagnostic evaluations completed prior to 2 years old. Clinical diagnosis of autism was based on results of in-person diagnostic autism evaluations by research reliable testers blind to screening results and using the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) Toddler Module and Mullen Scales of Early Learning (MSEL) per standard guidelines. RESULTS: While the M-CHAT-R/F had higher specificity and PPV compared to M-CHAT-R, Q-CHAT-10-O showed higher sensitivity than M-CHAT-R/F and Q-CHAT-10. LIMITATIONS: Many parents declined participation and the sample is over-represented by higher educated parents. Results cannot be extended to older ages. CONCLUSIONS: Limitations of the currently recommended two-stage M-CHAT-R/F at the 18-month visit include low sensitivity with minimal balancing benefit of improved PPV from the follow-up interview. Ordinal, rather than dichotomous, scoring of autism screening items appears to be beneficial at this age. The Q-CHAT-10-O with ordinal scoring shows advantages to M-CHAT-R/F with half the number of items, no requirement for a follow-up interview, and improved sensitivity. Yet, Q-CHAT-10-O sensitivity is less than M-CHAT-R (without follow-up) and specificity is less than the two-stage procedure. Such limitations are consistent with recognition that screening needs to recur beyond this age

Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels

Most cell cycle-regulated genes adopt non-optimal codon usage, namely, their translation involves wobbly matching codons. Here, the authors show that tRNA expression is cyclic and that codon usage, therefore, can give rise to cell-cycle regulation of proteins

Stress Measurement in Primary Care: Conceptual Issues, Barriers, Resources, and Recommendations for Study

Objective: Exposure to stressors in daily life and dysregulated stress responses are associated with increased risk for a variety of chronic mental and physical health problems, including anxiety disorders, depression, asthma, heart disease, certain cancers, and autoimmune and neurodegenerative disorders. Despite this fact, stress exposure and responses are rarely assessed in the primary care setting and infrequently targeted for disease prevention or treatment. Method: In this narrative review, we describe the primary reasons for this striking disjoint between the centrality of stress for promoting disease and how rarely it is assessed by summarizing the main conceptual, measurement, practical, and reimbursement issues that have made stress difficult to routinely measure in primary care. The following issues will be reviewed: (1) assessment of stress in primary care; (2) biobehavioral pathways linking stress and illness; (3) the value of stress measurements for improving outcomes in primary care; (4) barriers to measuring and managing stress; and (5) key research questions relevant to stress assessment and intervention in primary care. Results: Based on our synthesis, we suggest several approaches that can be pursued to advance this work, including feasibility and acceptability studies, cost-benefit studies, and clinical improvement studies. Conclusions: Although stress is recognized as a key contributor to chronic disease risk and mortality, additional research is needed to determine how and when instruments for assessing life stress might be useful in the primary care setting, and how stress-related data could be integrated into disease prevention and treatment strategies to reduce chronic disease burden and improve human health and wellbeing

Dynamic Proteomics: a database for dynamics and localizations of endogenous fluorescently-tagged proteins in living human cells

Recent advances allow tracking the levels and locations of a thousand proteins in individual living human cells over time using a library of annotated reporter cell clones (LARC). This library was created by Cohen et al. to study the proteome dynamics of a human lung carcinoma cell-line treated with an anti-cancer drug. Here, we report the Dynamic Proteomics database for the proteins studied by Cohen et al. Each cell-line clone in LARC has a protein tagged with yellow fluorescent protein, expressed from its endogenous chromosomal location, under its natural regulation. The Dynamic Proteomics interface facilitates searches for genes of interest, downloads of protein fluorescent movies and alignments of dynamics following drug addition. Each protein in the database is displayed with its annotation, cDNA sequence, fluorescent images and movies obtained by the time-lapse microscopy. The protein dynamics in the database represents a quantitative trace of the protein fluorescence levels in nucleus and cytoplasm produced by image analysis of movies over time. Furthermore, a sequence analysis provides a search and comparison of up to 50 input DNA sequences with all cDNAs in the library. The raw movies may be useful as a benchmark for developing image analysis tools for individual-cell dynamic-proteomics. The database is available at http://www.dynamicproteomics.net/

Great expectations: millennial lawyers and the structures of contemporary legal practice

This paper presents the findings of the first empirical study of the experiences of young lawyers who have entered an increasingly uncertain profession following a highly competitive education and recruitment process. These ‘millennial lawyers’ are framed by a narrative of ‘difference’. This ‘difference’ is commonly articulated negatively and as a challenge to organisational and professional norms. However, our findings suggest a more complex reality. In its synthesis of work on structure and agency, with the temporal focus required by generational sociology, this paper advances an original approach to the analysis of organisational and professional change within contemporary legal practice. Drawing on new empirical research, it demonstrates that although our sample shares many field-level expectations, there is also considerable stress, unhappiness and discomfort. This is generated by a complex interaction between the lawyers’ expectations of practice, and the structuring properties of the field. Thus, the capacity for organisational and professional change is more comprehensively understood within a temporal frame. This paper challenges academic and professional paradigms of generational change within the legal field. It concludes with recommendations for legal educators and the profession which foreground the complexity of millennial lawyers’ expectations of practice