870 research outputs found

    Зміст та обсяг поняття «корупційне кримінальне правопорушення» у кримінальному праві України

    Get PDF
    The article states that both in the doctrine of criminal law and in law enforcement practice, there are still unresolved problems related to the content and scope of the concept of «corruption criminal offense». After the introduction of the concept of corruption crime into the Criminal Code of Ukraine in the footnote to Art. 45 of the Criminal Code of Ukraine, scientific discussions have changed their emphasis on the analysis of the validity of the definition of the relevant concept in the form of an exhaustive list of crimes belonging to the elements of corruption; concentrated on the list itself, defined by the legislator, on its addition or, on the contrary, reduction. The purpose of this article was to generalize scientific positions regarding the content and scope of the concept of corruption criminal offense and to define on this basis the author’s definition of the corresponding concept.It has been established that the main vectors to which the scientific results of the studies covered in the special literature are aimed are three: 1) addition, expansion of the list defined in the footnote to Art. 45 of the list of corruption criminal offenses; 2) reduction, narrowing of such a list. The list of corruption criminal offenses, and it acts in this case as the scope of the concept of «corruption criminal offense», directly depends on the content of this concept. In this context, attempts to define the concept of corruption criminal offense using a certain set of features that characterize the two concepts that meaningfully make it up: «corruption» and «criminal offense» seem productive. Both of these concepts are normatively defined: the Law of Ukraine «On Prevention of Corruption» and Art. 11 of the Criminal Code of Ukraine contain relevant definitions.The article proposes to leave in the definition a list of «unconditionally corrupt» criminal offenses, the constitutive features of which are signs of corruption offenses: abuse of official position in the broad sense and the presence of unlawful gain as the purpose, object or means of committing the offense. Article should be excluded from the current version of such a list. 210 of the Criminal Code of Ukraine. However, this will not mean that an act that falls under this criminal law prohibition cannot be corrupt. It should be considered in the context of the second group of encroachments - corruption «under condition». When formulating the definition of this group, it seems worth abandoning an exhaustive list, indicating in the normative provision the signs of the actual composition of the encroachment.У статті констатується, що і у доктрині кримінального права, і у правозастосовній практиці залишилися невирішені проблеми, пов’язані саме із змістом та обсягом поняття «корупційне кримінальне правопорушення». Після введення до КК України поняття корупційного злочину у примітці до ст. 45 КК України, наукові дискусії змінили свій акцент на аналізі обґрунтованості визначення відповідного поняття у спосіб вичерпного переліку належних до корупційних складів злочинів; концентрувалися на самому, визначеному законодавцем, переліку, на його доповненні або, навпаки, скороченні. Мета цієї статті полягала в узагальненні наукових позицій стосовно змісту та обсягу поняття корупційне кримінальне правопорушення та визначення на цій основі авторської дефініції відповідного поняття. Встановлено, що основними векторами, на які спрямовані наукові результати висвітлених у спеціальній літературі досліджень, є три: 1) доповнення, розширення переліку визначених у примітці до ст. 45 переліку корупційних кримінальних правопорушень; 2) скорочення, звуження такого переліку. Перелік корупційних кримінальних правопорушень, а він виступає у даному випадку обсягом поняття «корупційне кримінальне правопорушення», безпосередньо залежить від змісту цього поняття. У цьому контексті продуктивними видаються спроби визначити поняття корупційне кримінальне правопорушення із використанням певної сукупності ознак, які характеризують два поняття, які його змістовно складають: «корупція» та «кримінальне правопорушення». Обидва ці поняття є нормативно визначені: Закон України «Про запобігання корупції» та ст. 11 КК України містять відповідні дефініції.У статті пропонується залишити у визначенні перелік «безумовно корупційних» кримінальних правопорушень, конститутивними ознаками складів яких є ознаки корупційних посягань: зловживання службовим становищем у широкому смислі та наявність неправомірно вигоди як мети, предмету чи засобу вчинення правопорушення. Із чинної редакції такого переліку варто виключити ст. 210 КК України. Однак це не означатиме, що діяння, яке підпадає під цю кримінально-правову заборону, не може бути корупційним. Його варто розглядати у контексті другої групи посягань – корупційних «під умовою». Формулюючи визначення цієї групи, видається варто відмовитись від вичерпного переліку, навівши у нормативному положенні ознаки фактичного складу посягання

    Serologic tests for detecting antibodies against Mycobacterium bovis and Mycobacterium avium subspecies paratuberculosis in Eurasian wild boar (Sus scrofa scrofa)

    Get PDF
    Boadella et al.New tools to detect exposure of free-range Eurasian wild boar (Sus scrofa scrofa) to pathogenic mycobacteria would be valuable for improved disease surveillance and wildlife management. Two hundred sera from wild boar of known Mycobacterium bovis infection status were used to evaluate test suitability for the detection of antibodies against M. bovis and Mycobacterium avium subsp. paratuberculosis (or crossreacting members of the M. avium complex). Two traditional enzyme-linked immunosorbent assays were evaluated using M. bovis purified protein derivative (bPPD) and paratuberculosis protoplasmatic antigen 3 (PPA3) as antigens, respectively, and a new point-of-care test format for bovine tuberculosis (bTB) that uses the innovative dual-path platform (DPP TB) test. The effect of individual factors (sex, age, lesions) on the diagnostic performance of the serologic tests was also determined. Although the DPP had a sensitivity of 89.6% and a specificity of 90.4%, for bPPD, the sensitivity was 79.2% and the specificity 100%. Both tests had a kappa agreement of 0.80. Sixty-five of 68 (95.6%) wild boar sera with antibodies against the PPA3 antigen corresponded to known M. bovis-infected wild boar. Significant differences were not observed in the bPPD and DPP readings among lesion categories or between age classes. A slight sex-related difference in sensitivity toward males in the DPP was found, but it was not detected in the bPPD enzyme-linked immunosorbent assay. The results support the use of antibody-based diagnostic tests for both large-scale and individual bTB testing of Eurasian wild boar and suggest that wild boar cannot be used as sentinels for infections caused by M. avium complex members.The current study is a contribution to MCINN Plan Nacional I+D+i research grant AGL2008-03875 and FEDER and to FP7 EU grant TB-STEP (212414). Studies on diseases shared between domestic animals and wildlife are also supported by Grupo Santander Fundacion Marcelino Botin. Tania Carta acknowledges a grant from Regione Sardegna.Peer Reviewe

    Testing Eurasian wild boar piglets for serum antibodies against Mycobacterium bovis

    Get PDF
    A. Che’ Amat et al.Animal tuberculosis (TB) caused by infection with Mycobacterium bovis and closely related members of the M. tuberculosis complex (MTC), is often reported in the Eurasian wild boar (. Sus scrofa). Tests detecting antibodies against MTC antigens are valuable tools for TB monitoring and control in suids. However, only limited knowledge exists on serology test performance in 2-6 month-old piglets. In this age-class, recent infections might cause lower antibody levels and lower test sensitivity. We examined 126 wild boar piglets from a TB-endemic site using 6 antibody detection tests in order to assess test performance. Bacterial culture (. n=. 53) yielded a M. bovis infection prevalence of 33.9%, while serum antibody prevalence estimated by different tests ranged from 19% to 38%, reaching sensitivities between 15.4% and 46.2% for plate ELISAs and between 61.5% and 69.2% for rapid immunochromatographic tests based on dual path platform (DPP) technology. The Cohen kappa coefficient of agreement between DPP WTB (Wildlife TB) assay and culture results was moderate (0.45) and all other serological tests used had poor to fair agreements. This survey revealed the ability of several tests for detecting serum antibodies against the MTC antigens in 2-6 month-old naturally infected wild boar piglets. The best performance was demonstrated for DPP tests. The results confirmed our initial hypothesis of a lower sensitivity of serology for detecting M. bovis-infected piglets, as compared to older wild boar. Certain tests, notably the rapid animal-side tests, can contribute to TB control strategies by enabling the setup of test and cull schemes or improving pre-movement testing. However, sub-optimal test performance in piglets as compared to that in older wild boar should be taken into account.This is a contribution to Spanish Government MINECO Plan Nacional I+D+I grant AGL2014-56305 and FEDER, to a contract between CDTI and Glenton, and to the EU FP7 grant WildTBvac #613779. Azlan Che Amat has a PhD grant from the Malaysian Government, and José Angel Barasona and Iratxe Diéz-Delgado acknowledge PhD grants from the Spanish Government.Peer Reviewe

    Understanding the electromagnetic interaction of metal organic framework reactants in aqueous solution at microwave frequencies

    Get PDF
    Preparation of metal organic frameworks (MOFs) via microwave heating is becoming increasingly popular due to reduced reaction times and enhanced control of MOF particle size. However, there is little understanding about the detailed interaction of the electric field portion of the wave with reactants during the synthesis of MOFs. In order to overcome this lack of fundamental understanding, information about the dielectric properties of the reactants is required. In this work the dielectric constants (ε′) and loss factors (ε′′) of benzene-1,4-dicarboxylic acid (H2BDC; also known as terephthalic acid) and a number of M(III) (M = metal) salts dissolved in deionized water were measured as a function of frequency, temperature and concentration and with varying anions and cations. Dielectric data confirm the aqueous M(III) salts to be strong microwave absorbers, particularly at 915 MHz. M(III) salts with mono-anionic ligands (for example chlorides and nitrates) exhibit higher losses than di-anionic salts (sulfates) demonstrating that the former are heated more effectively in an applied microwave field. Of the M(III) salts containing either singly- or doubly-charged anions, those containing Fe(III) have the highest loss indicating that they will heat more efficiently than other M(III) salts such as Cr(III) and Al(III). Interestingly, H2BDC exhibits little interaction with the electric field at microwave frequencies

    Current problems of study of disciplines of general surgery

    Get PDF
    It is knovvTi tiiat the increased role o f information and information technology has led to the fact that modem society exists at a new information stage of development

    Oral vaccination with heat inactivated Mycobacterium bovis activates the complement system to protect against tuberculosis

    Get PDF
    Tuberculosis (TB) remains a pandemic affecting billions of people worldwide, thus stressing the need for new vaccines. Defining the correlates of vaccine protection is essential to achieve this goal. In this study, we used the wild boar model for mycobacterial infection and TB to characterize the protective mechanisms elicited by a new heat inactivated Mycobacterium bovis vaccine (IV). Oral vaccination with the IV resulted in significantly lower culture and lesion scores, particularly in the thorax, suggesting that the IV might provide a novel vaccine for TB control with special impact on the prevention of pulmonary disease, which is one of the limitations of current vaccines. Oral vaccination with the IV induced an adaptive antibody response and activation of the innate immune response including the complement component C3 and inflammasome. Mycobacterial DNA/RNA was not involved in inflammasome activation but increased C3 production by a still unknown mechanism. The results also suggested a protective mechanism mediated by the activation of IFN-γ producing CD8+ T cells by MHC I antigen presenting dendritic cells (DCs) in response to vaccination with the IV, without a clear role for Th1 CD4+ T cells. These results support a role for DCs in triggering the immune response to the IV through a mechanism similar to the phagocyte response to PAMPs with a central role for C3 in protection against mycobacterial infection. Higher C3 levels may allow increased opsonophagocytosis and effective bacterial clearance, while interfering with CR3-mediated opsonic and nonopsonic phagocytosis of mycobacteria, a process that could be enhanced by specific antibodies against mycobacterial proteins induced by vaccination with the IV. These results suggest that the IV acts through novel mechanisms to protect against TB in wild boar.This research was supported by Plan Nacional I+D+I AGL2011-30041 from Ministerio de Economía y Competitividad (MINECO), Spain and FEDER. This is also a contribution to EU FP7 grant WildTBvac and the EU FP7 ANTIGONE project number 278976. R.C. Galindo was funded by MEC, Spain. B. Beltrán-Beck was supported by MINECO grant BES-2009-017401.Peer Reviewe

    Ion binding in the Open HCN Pacemaker Channel Pore: Fast Mechanisms to Shape “Slow” Channels

    Get PDF
    IH pacemaker channels carry a mixed monovalent cation current that, under physiological ion gradients, reverses at ∼−34 mV, reflecting a 4:1 selectivity for K over Na. However, IH channels display anomalous behavior with respect to permeant ions such that (a) open channels do not exhibit the outward rectification anticipated assuming independence; (b) gating and selectivity are sensitive to the identity and concentrations of externally presented permeant ions; (c) the channels' ability to carry an inward Na current requires the presence of external K even though K is a minor charge carrier at negative voltages. Here we show that open HCN channels (the hyperpolarization-activated, cyclic nucleotide sensitive pore forming subunits of IH) undergo a fast, voltage-dependent block by intracellular Mg in a manner that suggests the ion binds close to, or within, the selectivity filter. Eliminating internal divalent ion block reveals that (a) the K dependence of conduction is mediated via K occupancy of site(s) within the pore and that asymmetrical occupancy and/or coupling of these sites to flux further shapes ion flow, and (b) the kinetics of equilibration between K-vacant and K-occupied states of the pore (10–20 μs or faster) is close to the ion transit time when the pore is occupied by K alone (∼0.5–3 μs), a finding that indicates that either ion:ion repulsion involving Na is adequate to support flux (albeit at a rate below our detection threshold) and/or the pore undergoes rapid, permeant ion-sensitive equilibration between nonconducting and conducting configurations. Biophysically, further exploration of the Mg site and of interactions of Na and K within the pore will tell us much about the architecture and operation of this unusual pore. Physiologically, these results suggest ways in which “slow” pacemaker channels may contribute dynamically to the shaping of fast processes such as Na-K or Ca action potentials

    Investigation of two-photon electron capture by H-like uranium

    Full text link
    We present a study of two-photon electron capture by H-like uranium ions. The energy of the incident electron was chosen to be in the region with the most significant contribution of the dielectric recombination. We studied the photon emission spectrum, including the main resonance groups corresponding to the cascade transition, and the low-energy photon region, where the infrared divergence required special processing. The calculations were performed within the framework of QED theory. The importance of generalized Breit interaction was discussed. We investigated the roles of the dielectric recombination and the radiative recombination. We introduced and investigated the resonance approximation and the single-photon approximation, which are commonly used to describe radiation spectra
    corecore