China, the United States, and the Climate Change Challenge

Outlines China's climate change policy, U.S. concerns about transfer of carbon-intensive jobs to China and ways to address them, ways for U.S. policy and legislation to spur China's adoption of clean technologies, and specific mechanisms for cooperation

Dihydrogen Activation with a Neutral, Intermolecular Silicon(IV)‐Amine Frustrated Lewis Pair

The heterolytic cleavage of dihydrogen constitutes the hallmark reaction of frustrated Lewis pairs (FLP). While being well‐established for planar Lewis acids, such as boranes or silylium ions, the observation of the primary H2 splitting products with non‐planar Lewis acid FLPs remained elusive. In the present work, we report bis(perfluoro‐N‐phenyl‐ortho‐amidophenolato)silane and its application in dihydrogen activation to a fully characterized hydridosilicate. The strict design of the Lewis acid, the limited selection of the Lewis base, and the distinct reaction conditions emphasize the narrow tolerance to achieve this fascinating process with a tetrahedral Lewis acid

3, 2, 1 … Discovering Newton’s Laws

“For every action there is an equal and opposite reaction.” “Except when a bug hits your car window, the car must exert more force on the bug because Newton’s laws only apply in the physics classroom, right?” Students in our classrooms were able to pick out definitions as well as examples of Newton’s three laws; they could recite the laws and even solve for force, mass, and acceleration. However, when given “real world” questions, they would quickly revert to naive explanations. This frustration led to an examination of our approach to teaching Newton’s laws. Like many, we taught Newton’s laws in their numerical order—first, second, and then third. Students read about the laws, copied definitions, and became proficient with vocabulary before they applied the laws in a lab setting. This paper discusses how we transformed our teaching of Newton’s laws by flipping the order (3, 2, 1) and putting the activity before concept, as well as how these changes affected student outcomes

Supported accommodation evaluation framework (SAEF) guide

High hopes for the NDIS are that people with disability will be able to live as independently as they choose, with the housing of their choice, and with the paid support that suits their preferences and life goals. Research conducted by the Social Policy Research Centre for the NSW government about disability housing support that is like the NDIS found that most people did achieve some positive outcomes. Least change was evident in people’s interpersonal relationships and employment, and some people did not live in housing that met their needs.&nbsp

The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation

ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been implicated in female fertility. In the C57BL/6NTac mouse, a mutation in Zfp36l2 that results in the decreased expression of a form of ZFP36L2 in which the 29 N-terminal amino acid residues have been deleted, ΔN-ZFP36L2, leads to fertilized eggs that arrest at the two-cell stage. Interestingly, homozygous ΔN-Zfp36l2 females in the C57BL/6NTac strain release 40% fewer eggs than the WT littermates (Ramos et al., 2004), suggesting an additional defect in ovulation and/or oocyte maturation. Curiously, the same ΔN-Zfp36l2 mutation into the SV129 strain resulted in anovulation, prompting us to investigate a potential problem in ovulation and oocyte maturation. Remarkably, only 20% of ΔN-Zfp36l2 oocytes in the 129S6/SvEvTac strain matured ex vivo, suggesting a defect on the oocyte meiotic maturation process. Treatment of ΔN-Zfp36l2 oocytes with a PKA inhibitor partially rescued the meiotic arrested oocytes. Furthermore, cAMP levels were increased in ΔN-Zfp36l2 oocytes, linking the cAMP/PKA pathway and ΔN-Zfp36l2 with meiotic arrest. Since ovulation and oocyte maturation are both triggered by LHR signaling, the downstream pathway was investigated. Adenylyl cyclase activity was increased in ΔN-Zfp36l2 ovaries only upon LH stimulation. Moreover, we discovered that ZFP36L2 interacts with the 3′UTR of LHR mRNA and that decreased expression levels of Zfp36l2 correlates with higher levels of LHR mRNA in synchronized ovaries. Furthermore, overexpression of ZFP36L2 decreases the endogenous expression of LHR mRNA in a cell line. Therefore, we propose that lack of the physiological down regulation of LHR mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest.Fil: Ball, Christopher B.. University of North Carolina; Estados UnidosFil: Rodriguez, Karina F.. National Institutes of Health; Estados UnidosFil: Stumpo, Deborah J.. National Institutes of Health; Estados UnidosFil: Ribeiro Neto, Fernando. National Institutes of Health; Estados UnidosFil: Korach, Kenneth S.. National Institutes of Health; Estados UnidosFil: Blackshear, Perry J.. University of Duke; Estados Unidos. National Institutes of Health; Estados UnidosFil: Birnbaumer, Lutz. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramos, Silvia B. V.. University of North Carolina; Estados Unido

Beyond the Scope: Using Motion Capture Data from Bronchoscopy Simulations to Build Feedback Models

Mannequin simulators and task trainers are commonly used in health sciences training programs to teach techniques performed during medical procedures. However, there are drawbacks to their deployment. First and foremost, the cost of high-fidelity task trainers is prohibitively expensive for many programs. Additionally, the combination of mannequin-to-learner and teacher-to-learner ratios often makes it difficult to efficiently teach procedures to a large number of students. This project aims to create a low-cost, game-based, easily portable task trainer to assist learners in building skills and expertise in performing bronchoscopies. This preliminary report focuses on designing a motion capture device to record hand, wrist, and thumb motions performed by experts and learners during simulated bronchoscopy procedures and then using this captured data to construct computational feedback models

Calix[4]pyrrolato Aluminate Catalyzes the Dehydrocoupling of Phenylphosphine Borane to High Molar Weight Polymers

High molar weight polyphosphinoboranes represent materials with auspicious properties, but their preparation requires transition metal-based catalysts. Here, calix[4]pyrrolato aluminate is shown to induce the dehydropolymerization of phosphine boranes to high molar mass polyphosphinoboranes (up to Mn=43 000 Da). Combined GPC and 31P DOSY NMR spectroscopic analyses, quantum chemical computations, and stoichiometric reactions disclose a P−H bond activation by the cooperative action of the square-planar aluminate and the electron-rich ligand framework. This first transition metal-free catalyst for P−B dehydrocoupling overcomes the problem of residual d-block metal impurities in the resulting polymers that might interfere with the reproducibility of the properties for this emerging class of inorganic materials

Zur Kontextualisierung der Inklusionsforschung

Der Anteil von Drittmitteln in der Finanzierung der Hochschulen ist deutlich gestiegen und damit auch der Druck auf die Wissenschaftler*innen, diese erfolgreich einzuwerben. Hinzu getreten ist in den letzten Jahren die verstärkte Forderung danach, dass die so gewonnenen Forschungsergebnisse auch ihren Niederschlag in einer – veränderten – Schulpraxis finden sollen. Man mag diese Entwicklungen begrüßen oder ihnen skeptisch gegenüberstehen, sie markieren aber die Rahmenbedingungen, unter denen auch die Inklusionsforschung arbeitet. Im vorliegenden Beitrag wird den damit einhergehenden Ambivalenzen nachgegangen. (DIPF/Orig.