529 research outputs found
Topographic Wetness Index as a Proxy for Soil Moisture : The Importance of Flow-Routing Algorithm and Grid Resolution
The Topographic Wetness Index (TWI) is a commonly used proxy for soil moisture. The predictive capability of TWI is influenced by the flow-routing algorithm and the resolution of the Digital Elevation Model (DEM) that TWI is derived from. Here, we examine the predictive capability of TWI using 11 flow-routing algorithms at DEM resolutions 1-30 m. We analyze the relationship between TWI and field-quantified soil moisture using statistical modeling methods and 5,200 study plots with over 46 000 soil moisture measurements. In addition, we test the sensitivity of the flow-routing algorithms against vertical height errors in DEM at different resolutions. The results reveal that the overall predictive capability of TWI was modest. The highest r(2) (23.7%) was reached using a multiple-flow-direction algorithm at 2 m resolution. In addition, the test of sensitivity against height errors revealed that the multiple-flow-direction algorithms were also more robust against DEM errors than single-flow-direction algorithms. The results provide field-evidence indicating that at its best TWI is a modest proxy for soil moisture and its predictive capability is influenced by the flow-routing algorithm and DEM resolution. Thus, we encourage careful evaluation of algorithms and resolutions when using TWI as a proxy for soil moisture.Peer reviewe
Topographic Wetness Index as a Proxy for Soil Moisture : The Importance of Flow-Routing Algorithm and Grid Resolution
The Topographic Wetness Index (TWI) is a commonly used proxy for soil moisture. The predictive capability of TWI is influenced by the flow-routing algorithm and the resolution of the Digital Elevation Model (DEM) that TWI is derived from. Here, we examine the predictive capability of TWI using 11 flow-routing algorithms at DEM resolutions 1-30 m. We analyze the relationship between TWI and field-quantified soil moisture using statistical modeling methods and 5,200 study plots with over 46 000 soil moisture measurements. In addition, we test the sensitivity of the flow-routing algorithms against vertical height errors in DEM at different resolutions. The results reveal that the overall predictive capability of TWI was modest. The highest r(2) (23.7%) was reached using a multiple-flow-direction algorithm at 2 m resolution. In addition, the test of sensitivity against height errors revealed that the multiple-flow-direction algorithms were also more robust against DEM errors than single-flow-direction algorithms. The results provide field-evidence indicating that at its best TWI is a modest proxy for soil moisture and its predictive capability is influenced by the flow-routing algorithm and DEM resolution. Thus, we encourage careful evaluation of algorithms and resolutions when using TWI as a proxy for soil moisture.Peer reviewe
Tracking the Limnoecological History of Lake Hiidenvesi (Southern Finland) Using the Paleolimnological Approach
Correction: Water, Air and Soil Pollution, 230 :9 (2019), art. 228 DOI: 10.1007/s11270-019-4262-2We examined a sediment record from Lake Hiidenvesi in southern Finland using paleolimnological methods to trace its limnoecological history. In our record, beginning from the 1940s, chironomid (Diptera) assemblages shifted from typical boreal taxa towards mesotrophic community assemblages at similar to 1960-1980 CE being finally replaced by eutrophic taxa from the 1990s onward. The diatom (Bacillariophyceae) assemblages reflected relatively nutrient rich conditions throughout the record showing a further increase in eutrophic taxa from the 1970s onward. A chironomid-based reconstruction of late-winter hypolimnetic dissolved oxygen (DO) conditions suggested anoxic conditions already in the 1950s, probably reflecting increased inlake production due to allochthonous nutrient inputs and related increase in biological oxygen consumption. However, the reconstruction also indicated large variability in long-term oxygen conditions that appear typical for the basin. With regard to nutrient status, chironomid- and diatom-based reconstructions of total phosphorus (TP) showed a similar trend throughout the record, although, chironomids indicated a more straightforward eutrophication process in the benthic habitat and seemed to reflect the intensified human activities in the catchment more strongly than diatoms. The DO and TP reconstructions were mostly similar in trends compared to the measured data available since the 1970s/1980s. However, the increase in TP during the most recent years in both reconstructions was not visible in the monitored data. The results of our multiproxy study emphasize the significance of including both epilimnetic and hypolimnetic systems in water quality assessments and provide important long-term limnoecological information that will be useful in the future when setting targets for restoration.Peer reviewe
CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques
Introduction
APOE is the strongest risk gene for sporadic Alzheimer's disease (AD) so far. Recent genome wide association studies found links for sporadic AD with CLU and CR1 involved in Aβ clearance, and PICALM affecting intracellular trafficking.
Methods
We investigated the associations of senile plaques (SP) and neurofibrillary tangles (NFT) with the proposed risk genes and APOE, in the Tampere Autopsy Study (TASTY) series (603 cases), a sample of the general population (0 to 97 yrs), who died out-of-hospital.
Results
Age and the APOEε4 allele associated strongly with all phenotypes of SP, as expected. In age and APOEε4 adjusted analyses, compared to the most common homozygous genotype, burnt out SP were more common among carriers of the C-allele of CLU, whereas the T-allele of PICALM and C-allele of CR1 were linked with lower SP coverage. We found no significant associations between any of the genetic variants and NFT.
Conclusions
Marginal effects from CLU, CR1 and PICALM suggest that these genes have minimal effects on the development of AD lesions.BioMed Central Open acces
Two independent evolutionary routes to Na+/H+ cotransport function in membrane pyrophosphatases.
Membrane-bound pyrophosphatases (mPPases) hydrolyze pyrophosphate (PPi)
to transport H(+), Na(+) or both and help organisms to cope with stress
conditions, such as high salinity or limiting nutrients. Recent
elucidation of mPPase structure and identification of subfamilies that
have fully or partially switched from Na(+) to H(+) pumping have
established mPPases as versatile models for studying the principles
governing the mechanism, specificity and evolution of cation
transporters. In the present study, we constructed an accurate
phylogenetic map of the interface of Na(+)-transporting PPases
(Na(+)-PPases) and Na(+)- and H(+)-transporting PPases
(Na(+),H(+)-PPases), which guided our experimental exploration of the
variations in PPi hydrolysis and ion transport activities during
evolution. Surprisingly, we identified two mPPase lineages that
independently acquired physiologically significant Na(+) and H(+)
cotransport function. Na(+),H(+)-PPases of the first lineage transport
H(+) over an extended [Na(+)] range, but progressively lose H(+)
transport efficiency at high [Na(+)]. In contrast, H(+)-transport by
Na(+),H(+)-PPases of the second lineage is not inhibited by up to 100 mM
Na(+) With the identification of Na(+),H(+)-PPase subtypes, the mPPases
protein superfamily appears as a continuum, ranging from monospecific
Na(+) transporters to transporters with tunable levels of Na(+) and H(+)
cotransport and further to monospecific H(+) transporters. Our results
lend credence to the concept that Na(+) and H(+) are transported by
similar mechanisms, allowing the relative efficiencies of Na(+) and H(+)
transport to be modulated by minor changes in protein structure during
the course of adaptation to a changing environment. </p
Chronic non-specific low back pain - sub-groups or a single mechanism?
Copyright 2008 Wand and O'Connell; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: Low back pain is a substantial health problem and has subsequently attracted a
considerable amount of research. Clinical trials evaluating the efficacy of a variety of interventions
for chronic non-specific low back pain indicate limited effectiveness for most commonly applied
interventions and approaches.
Discussion: Many clinicians challenge the results of clinical trials as they feel that this lack of
effectiveness is at odds with their clinical experience of managing patients with back pain. A
common explanation for this discrepancy is the perceived heterogeneity of patients with chronic
non-specific low back pain. It is felt that the effects of treatment may be diluted by the application
of a single intervention to a complex, heterogeneous group with diverse treatment needs. This
argument presupposes that current treatment is effective when applied to the correct patient.
An alternative perspective is that the clinical trials are correct and current treatments have limited
efficacy. Preoccupation with sub-grouping may stifle engagement with this view and it is important
that the sub-grouping paradigm is closely examined. This paper argues that there are numerous
problems with the sub-grouping approach and that it may not be an important reason for the
disappointing results of clinical trials. We propose instead that current treatment may be ineffective
because it has been misdirected. Recent evidence that demonstrates changes within the brain in
chronic low back pain sufferers raises the possibility that persistent back pain may be a problem of
cortical reorganisation and degeneration. This perspective offers interesting insights into the
chronic low back pain experience and suggests alternative models of intervention.
Summary: The disappointing results of clinical research are commonly explained by the failure of
researchers to adequately attend to sub-grouping of the chronic non-specific low back pain
population. Alternatively, current approaches may be ineffective and clinicians and researchers may
need to radically rethink the nature of the problem and how it should best be managed
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