The Role and Value of Data in Realising Circular Business Models – a Systematic Literature Review

Peer reviewe

Future images of data in circular economy for textiles

Rapid expansion of digitalization and in the volume of data available constitutes a major driver toward circular economy. In the textile industry, with its vast quantities of waste and huge environmental impact, transformation toward such circularity is necessary but challenging. To explore how the use of data could support building sustainability-aligned pathways to circular economy of textiles, a study employing a two-round disaggregative Delphi approach (engaging 33 experts in the first round, in May 2021, and 26 in the second, in June 2021) articulated alternative images of the future. The three images, dubbed Transparency, Conflicting Interests, and Sustainable Textiles, imply that the role for data is intertwined with sustainability aspirations. The results highlight that exploiting data in pursuit of circular economy is a collaborative effort involving business value networks that include consumers and regulators. Availability and sharing of accountability-affording, meaningful data on textiles' life cycle and value network function as a key enabler. By working with the images developed, actors can better assess their circular-economy commitments, planned actions, and the consequences of these. Furthermore, the images provide a tool for mutual discussion of the development desired and of related re-sponsibilities and uncertainties.Peer reviewe

Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women

We examined whether polymorphisms of the vitamin D receptor (VDR) gene was associated with individual risk of hand osteoarthritis (OA). Radiographs of both hands of 295 dentists and of 248 teachers were examined and classified for the presence of OA using reference images. The VDR ApaI and TaqI genotypes were determined by PCR-based methods. No association was observed between the VDR polymorphisms and the odds of overall hand OA. However, the carriers of the VDR t allele or At haplotype were at almost half the odds of symmetrical hand OA (odds ratio [OR] = 0.60, 95% confidence interval [CI] = 0.38–0.94 and OR = 0.59, 95% CI = 0.38–0.93, respectively) compared with the carriers of the T allele and of the non-At haplotype, respectively. Increased odds of this disease, on the contrary, was observed for women with two copies of the VDR a allele (OR = 1.93, 95% CI = 1.99–3.70) compared with women with the AA genotype. Conversely, the VDR a allele carriage was associated with a tendency of lowered odds of osteophyte (OR = 0.51, 95% CI = 0.25–1.03). When the genotype data were used to construct haplotypes, the VDR AaTt joint genotype appeared to pose a remarkably lower odds (OR = 0.26, 95% CI = 0.08–0.91) of osteophyte compared with the AAtt joint genotype. As a novel finding we observed a joint effect of a low calcium intake and VDR polymorphisms on symmetrical OA; the OR was 2.64 (95% CI = 1.29–5.40) for carriers of the aT haplotype with low daily calcium intake compared with non-carriers of the haplotype with high daily calcium intake. Our results suggest that VDR gene polymorphisms play a role in the etiology of symmetrical hand OA. Moreover, the association between the VDR gene and OA may be modified by calcium intake

Käykö katteeksi? Muovin vaihtoehtoja luomumansikalla

MTT:ssä tutkitaan perinteisen mansikkamuovin rinnalla orgaanisia maanpinnan katteita. Tutkimushankkeessa selvitetään, miten erilaiset katteet toimivat ja millaisia eroja niissä on. Lisäksi tutkitaan, miten katteet vaikuttavat sadon säilymiseen, marjojen mikrobiologiseen laatuun ja mansikkapunkkiin.vokEKO/Karil

Future images of data in circular economy for textiles

Rapid expansion of digitalization and in the volume of data available constitutes a major driver toward circular economy. In the textile industry, with its vast quantities of waste and huge environmental impact, transformation toward such circularity is necessary but challenging. To explore how the use of data could support building sustainability-aligned pathways to circular economy of textiles, a study employing a two-round disaggregative Delphi approach (engaging 33 experts in the first round, in May 2021, and 26 in the second, in June 2021) articulated alternative images of the future. The three images, dubbed Transparency, Conflicting Interests, and Sustainable Textiles, imply that the role for data is intertwined with sustainability aspirations. The results highlight that exploiting data in pursuit of circular economy is a collaborative effort involving business value networks that include consumers and regulators. Availability and sharing of accountability-affording, meaningful data on textiles' life cycle and value network function as a key enabler. By working with the images developed, actors can better assess their circular-economy commitments, planned actions, and the consequences of these. Furthermore, the images provide a tool for mutual discussion of the development desired and of related responsibilities and uncertainties.</p

Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis

INTRODUCTION: The objective of this study was to investigate the relationship of the IL-6 promoter variants G-597A, G-572C and G-174C (rs1800797, rs1800796 and rs1800795, respectively), which have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal (DIP) osteoarthritis (OA). METHODS: A total of 535 women aged 45 to 63 years were included. Radiographs of both hands were taken and each DIP joint was evaluated (grade 0 to 4) for the presence of OA. Information on symptoms (pain, tenderness) in each joint was collected by using a self-administered questionnaire. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints, and symmetrical DIP OA by the presence of radiographic findings of grade 2 or more in at least one symmetrical pair of DIP joints. Common polymorphic loci in the IL-6 gene were amplified and the promoter haplotypes were reconstructed from genotype data with the PHASE program. Logistic regression analysis was used to examine the association between the IL-6 genotypes/diplotypes and the DIP OA outcome. RESULTS: The G alleles of two promoter single nucleotide polymorphisms (SNPs) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (P = 0.020 and 0.024, corrected for multiple testing). In addition, the carriage of at least one G allele in these positions increased the risk of disease (P = 0.006 and P = 0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than fourfold (odds ratio (OR) 4.45, P = 0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52, 95% confidence interval 1.01 to 2.28) and symptomatic DIP OA (OR 3.67, 95% confidence interval 1.50 to 9.00). CONCLUSION: The present study showed that the presence of G alleles at common IL-6 polymorphic promoter loci was associated with the more severe DIP OA outcomes, symmetrical and symptomatic