68 research outputs found
GW150914 and gravitational-wave astronomy
On September 14, 2015, the first detection of gravitational waves at the advanced Laser Interferometer Gravitational- Wave Observatory (LIGO) detectors, in the United States, marked the beginning of "gravitational-wave astronomy", that opens a new window looking into the violent sides of our Universe. It is very promising that at other wavelengths detections of gravitational waves with various space-based and ground-based observatories will show up in the near future of this century. These observatories include space-based laser interferometer antennas, pulsar timing arrays, cosmic microwave background satellites, etc
A collaborative and dynamic multi-source single-destination navigation algorithm for smart cities
An Efficient Dynamic Multi-Sources To Single-Destination (DMS-SD) Algorithm In Smart City Navigation Using Adjacent Matrix
Dijkstra's algorithm is one of the most popular classic path planning
algorithms, achieving optimal solutions across a wide range of challenging
tasks. However, it only calculates the shortest distance from one vertex to
another, which is hard to directly apply to the Dynamic Multi-Sources to
Single-Destination (DMS-SD) problem. This paper proposes a modified Dijkstra
algorithm to address the DMS-SD problem, where the destination can be
dynamically changed. Our method deploys the concept of Adjacent Matrix from
Floyd's algorithm and achieves the goal with mathematical calculations. We
formally show that all-pairs shortest distance information in Floyd's algorithm
is not required in our algorithm. Extensive experiments verify the scalability
and optimality of the proposed method.Comment: International Conference On Human-Centered Cognitive Systems (HCCS)
202
A Systematic Approach for Inertial Sensor Calibration of Gravity Recovery Satellites and Its Application to Taiji-1 Mission
High-precision inertial sensors or accelerometers can provide us references
of free-falling motions in gravitational field in space. They serve as the key
payloads for gravity recovery missions such as the CHAMP, the GRACE-type
missions, and the planned Next Generation Gravity Missions. In this work, a
systematic method of electrostatic inertial sensor calibrations for gravity
recovery satellites is suggested, which is applied to and verified with the
Taiji-1 mission. With this method, the complete operating parameters including
the scale factors, the center of mass offset vector and the intrinsic biased
acceleration can be precisely calibrated with only two sets of short-term
in-orbit experiments. Taiji-1 is the first technology demonstration satellite
of the "Taiji Program in Space", which, in its final extended phase in 2022,
could be viewed as operating in the mode of a high-low satellite-to-satellite
tracking gravity mission. Based on the calibration principles, swing maneuvers
with time span about 200 s and rolling maneuvers for 19 days were conducted by
Taiji-1 in 2022. The inertial sensor's operating parameters are precisely
re-calibrated with Kalman filters and are updated to the Taiji-1 science team.
Data from one of the sensitive axis is re-processed with the updated operating
parameters, and the performance is found to be slightly improved compared with
former results. This approach could be of high reference value for the
accelerometer or inertial sensor calibrations of the GFO, the Chinese
GRACE-type mission, and the Next Generation Gravity Missions. This could also
shed some light on the in-orbit calibrations of the ultra-precision inertial
sensors for future GW space antennas because of the technological inheritance
between these two generations of inertial sensors.Comment: 24 pages, 19 figure
Sagnac interferometry as a probe to the commutation relation of a macroscopic quantum mirror
Protective Effect of 18 β
Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological effects. However, hepatotoxicity of TP which is one of the toxic properties slows its progression in clinical application. 18β-Glycyrrhetinic acid (GA) is the main bioactive ingredient of Licorice (Glycyrrhiza glabra L.), a herbal medicine famous for its detoxification. This study aims to investigate whether GA possesses protective effect against TP-induced hepatotoxicity in rats. TP interference markedly elevated serum levels of ALT, AST, and ALP, caused evident liver histopathological changes, and elevated hepatic TNF-α, IL-6, IL-1β, and IFN-γ as well as nuclear translocation of NF-κB. TP also significantly elevated liver MDA and declined hepatic activities of SOD, CAT, and GSH-Px. Assay of TUNEL and apoptosis proteins (Bax, Bcl-2, and active caspase-3) showed that TP induced severe hepatocellular apoptosis. In contrast, low-dose GA (50 mg/kg) significantly reversed TP-induced changes above. However, high-dose GA (100 mg/kg) had no such effect. Overall, these findings indicated that low-dose GA but not high-dose GA exhibited a protective effect against TP-induced hepatotoxicity in rats by anti-inflammation, antioxidation, and antiapoptosis, which suggests that the doses of GA/Licorice should be carefully considered when used together with TWHF or TWHF preparations
Value of loop electrosurgical excision procedure conization and imaging for the diagnosis of papillary squamous cell carcinoma of the cervix
BackgroundLoop electrosurgical excision procedure (LEEP) conization and hysterectomy are performed for some patients with papillary squamous cell carcinoma (PSCC), whereas only hysterectomy is performed for others. We aimed to determine the optimal management for PSCC.MethodsPatients diagnosed with PSCC by colposcopy-directed biopsy between June 2008 and January 2020 who underwent LEEP conization and hysterectomy or only hysterectomy at our hospital were enrolled. Results of cervical cytology, high-risk human papillomavirus testing, transvaginal sonography, pelvic magnetic resonance imaging, LEEP, hysterectomy, and pathology testing of colposcopy-directed biopsy samples were analyzed.ResultsA total of 379 women were diagnosed with PSCC by colposcopy-directed biopsy; 174 underwent LEEP before hysterectomy and 205 underwent only hysterectomy. Patients underwent and did not undergo LEEP were aged 47 ± 11 years and 52 ± 11 years, respectively. Among women who underwent LEEP, the agreement between LEEP and hysterectomy pathology was 85.1%. For women who underwent only hysterectomy, the agreement between preoperative clinical staging and pathological staging after hysterectomy was 82.4%. For patients with preoperative imaging indicative of malignancy, the accuracy of LEEP for diagnosing and staging PSCC was 88.5%, whereas for the hysterectomy-only group, it was 86.2%. For patients without malignancy detected with imaging, the accuracy of LEEP for diagnosing and staging PSCC was 81.6%; however, for those who did not undergo LEEP, it was 70.0%.ConclusionFor women diagnosed with PSCC by colposcopy-directed biopsy, LEEP conization is necessary for an accurate diagnosis when imaging does not indicate cancer; however, LEEP is not necessary when imaging indicates cancer
Descope of the ALIA mission
The present work reports on a feasibility study commissioned by the Chinese
Academy of Sciences of China to explore various possible mission options to
detect gravitational waves in space alternative to that of the eLISA/LISA
mission concept. Based on the relative merits assigned to science and
technological viability, a few representative mission options descoped from the
ALIA mission are considered. A semi-analytic Monte Carlo simulation is carried
out to understand the cosmic black hole merger histories starting from
intermediate mass black holes at high redshift as well as the possible
scientific merits of the mission options considered in probing the light seed
black holes and their coevolution with galaxies in early Universe. The study
indicates that, by choosing the armlength of the interferometer to be three
million kilometers and shifting the sensitivity floor to around one-hundredth
Hz, together with a very moderate improvement on the position noise budget,
there are certain mission options capable of exploring light seed, intermediate
mass black hole binaries at high redshift that are not readily accessible to
eLISA/LISA, and yet the technological requirements seem to within reach in the
next few decades for China
GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses
IntroductionGliomas have emerged as the predominant brain tumor type in recent decades, yet the exploration of non-apoptotic cell death regulated by the pan-optosome complex, known as pan-apoptosis, remains largely unexplored in this context. This study aims to illuminate the molecular properties of pan-apoptosis-related genes in glioma patients, classifying them and developing a signature using machine learning techniques.MethodsThe prognostic significance, mutation features, immunological characteristics, and pharmaceutical prediction performance of this signature were comprehensively investigated. Furthermore, GPX8, a gene of interest, was extensively examined for its prognostic value, immunological characteristics, medication prediction performance, and immunotherapy prediction potential. ResultsExperimental techniques such as CCK-8, Transwell, and EdU investigations revealed that GPX8 acts as a tumor accelerator in gliomas. At the single-cell RNA sequencing level, GPX8 appeared to facilitate cell contact between tumor cells and macrophages, potentially enhancing microglial migration. ConclusionsThe incorporation of pan-apoptosis-related features shows promising potential for clinical applications in predicting tumor progression and advancing immunotherapeutic strategies. However, further in vitro and in vivo investigations are necessary to validate the tumorigenic and immunogenic processes associated with GPX8 in gliomas
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